The in vivo dissolution of tricalcium silicate bone cement

2021 ◽  
Author(s):  
Qing Lin ◽  
Xiaojuan Zhang ◽  
Dong Liang ◽  
Junlin Li ◽  
Wei Wang ◽  
...  
Keyword(s):  
Bone Cement ◽  
Tricalcium Silicate ◽  
In Vivo Dissolution

Mechanical Performance and In Vivo Tests of an Acrylic Bone Cement Filled with Bioactive Sepia Officinalis Cuttlebone

2010 ◽  
Vol 21 (1) ◽  
pp. 113-125 ◽  
Author(s):  
S. García-Enriquez ◽  
H. E. R. Guadarrama ◽  
I. Reyes-González ◽  
E. Mendizábal ◽  
C. F. Jasso-Gastinel ◽  
...  
Keyword(s):  
Bone Cement ◽  
Mechanical Performance ◽  
Sepia Officinalis ◽  
Acrylic Bone Cement ◽  
In Vivo Tests

Development of Novel Bioactive PMMA-Based Bone Cement and its In Vitro and In Vivo Evaluation

2006 ◽  
Vol 309-311 ◽  
pp. 801-804 ◽  
Author(s):  
S.B. Cho ◽  
Akari Takeuchi ◽  
Ill Yong Kim ◽  
Sang Bae Kim ◽  
Chikara Ohtsuki ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Compressive Strength ◽  
Bone Cement ◽  
The Novel ◽  
In Vivo Evaluation ◽  
Natural Bone ◽  
Pmma Bone Cement ◽  
Rabbit Tibia

In order to overcome the disadvantage of commercialized PMMA bone cement, we have developed novel PMMA-based bone cement(7P3S) reinforced by 30 wt.% of bioactive CaO-SiO2 gel powders to induce the bioactivity as well as to increase mechanical property for the PMMA bone cement. The novel 7P3S bone cement hardened after mixing for about 7 minutes. For in vitro evaluation, apatite forming ability of it was investigated using SBF. When the novel 7P3S bone cement was soaked into SBF, it formed apatite on its surfaces within 1 week Furthermore; there is no decrease in its compressive strength within 9 weeks soaking in SBF. It is though that hardly decrease in compressive strength of 7P3S bone cement in SBF is due to the relative small amount of gel powder or its spherical shape and monosize. In vivo evaluation of the novel 7P3S bone cement was carried out using rabbit. After implantion into rabbit tibia for several periods, the interface between novel bone cement and natural bone was evaluated by CT images. According to the results, the novel bone cement directly contact to the natural bone without fibrous tissue after implantation for 4 weeks. This results indicates that the newly developed 7P3S bone cement can bond to the living bone and also be effectively used as bioactive bone cement without decrease in mechanical property.

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

The improvement of the self-setting property of the tricalcium silicate bone cement with acid and its mechanism

2021 ◽  
Vol 150 ◽  
pp. 109825
Author(s):  
Zhengwen Ding ◽  
Wenjing Xi ◽  
Mizhi Ji ◽  
Xiaodan Li ◽  
Qiyi Zhang ◽  
...  
Keyword(s):  
Bone Cement ◽  
Tricalcium Silicate ◽  
The Self

scholarly journals Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

2020 ◽  
Vol 10 (18) ◽  
pp. 6528 ◽  
Author(s):  
Mayra Eliana Valencia Zapata ◽  
José Herminsul Mina Hernandez ◽  
Carlos David Grande Tovar ◽  
Carlos Humberto Valencia Llano ◽  
Blanca Vázquez-Lasa ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Cement ◽  
Orthopedic Surgery ◽  
Bending Strength ◽  
Orthopedic Implants ◽  
Parietal Bone ◽  
Maximum Temperature ◽  
Cement Interface

Acrylic bone cement (ABC) is one of the most used materials in orthopedic surgery, mainly for the fixation of orthopedic implants to the bone. However, ABCs usually present lack of biological activity and osseointegration capacity that leads to loosening of the prosthesis. This work reports the effect of introducing graphene oxide (GO) and chitosan (CS), separately or together, in the ABC formulation on setting performance, mechanical behavior, and biological properties. Introduction of both CS and GO to the ABC decreased the maximum temperature by 21% and increased the antibacterial activity against Escherichia coli by 87%, while introduction of only CS decreased bending strength by 32%. The results of cell viability and cell adhesion tests showed in vitro biocompatibility. The in vivo response was investigated using both subdermal and bone parietal implantations in Wistar rats. Modified ABCs showed absence of immune response, as confirmed by a normal inflammatory response in Wistar rat subdermal implantation. The results of the parietal bone implantation showed that the addition of CS and GO together allowed a near total healing bone–cement interface, as observed in the micrographic analysis. The overall results support the great potential of the modified ABCs for application in orthopedic surgery mainly in those cases where osseointegration is required.

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