Dendritic cells support a proliferative antigen‐specific T‐cell response in the presence of poly(lactic‐co‐glycolic acid)

2021 ◽  
Author(s):  
Sangeetha Srinivasan ◽  
Julia Babensee
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
Glycolic Acid ◽  
T Cell Response

Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice

2012 ◽  
Vol 59 (1,2) ◽  
pp. 95-101 ◽  
Author(s):  
Tohru Sakai ◽  
Emi Shuto ◽  
Tomoyo Taki ◽  
Honami Imamura ◽  
Miku Kioka ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Mhc Class Ii ◽  
Cell Response ◽  
Class Ii ◽  
T Cell Response ◽  
Cathepsin E

scholarly journals Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 ◽  
Vol 97 (5) ◽  
pp. 2185-2190 ◽  
Author(s):  
V. Russo ◽  
S. Tanzarella ◽  
P. Dalerba ◽  
D. Rigatti ◽  
P. Rovere ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Tumor Antigen ◽  
Cell Response ◽  
Human Tumor ◽  
T Cell Response ◽  
Class I ◽  
Apoptotic Cells

Induction of α-fetoprotein-specific CD4- and CD8-mediated T-cell response using RNA-transfected dendritic cells

2006 ◽  
Vol 239 (2) ◽  
pp. 144-150 ◽  
Author(s):  
Hong-Mei Zhang ◽  
Li-Wang Zhang ◽  
Jun Ren ◽  
Li Fan ◽  
Xiao-Ming Si ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response

scholarly journals Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1284
Author(s):  
Natalia Trempolec ◽  
Charline Degavre ◽  
Bastien Doix ◽  
Davide Brusa ◽  
Cyril Corbet ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Lipid Droplet ◽  
T Cell Activation ◽  
Cell Response ◽  
Cell Activation ◽  
Transforming Growth Factor ◽  
T Cell Response ◽  
Mesenchymal Transition

For poorly immunogenic tumors such as mesothelioma there is an imperious need to understand why antigen-presenting cells such as dendritic cells (DCs) are not prone to supporting the anticancer T cell response. The tumor microenvironment (TME) is thought to be a major contributor to this DC dysfunction. We have reported that the acidic TME component promotes lipid droplet (LD) formation together with epithelial-to-mesenchymal transition in cancer cells through autocrine transforming growth factor-β2 (TGF-β2) signaling. Since TGF-β is also a master regulator of immune tolerance, we have here examined whether acidosis can impede immunostimulatory DC activity. We have found that exposure of mesothelioma cells to acidosis promotes TGF-β2 secretion, which in turn leads to LD accumulation and profound metabolic rewiring in DCs. We have further documented how DCs exposed to the mesothelioma acidic milieu make the anticancer vaccine less efficient in vivo, with a reduced extent of both DC migratory potential and T cell activation. Interestingly, inhibition of TGF-β2 signaling and diacylglycerol O-acyltransferase (DGAT), the last enzyme involved in triglyceride synthesis, led to a significant restoration of DC activity and anticancer immune response. In conclusion, our study has identified that acidic mesothelioma milieu drives DC dysfunction and altered T cell response through pharmacologically reversible TGF-β2-dependent mechanisms.

scholarly journals Dendritic Cells Present an Intracellular Viral Antigen Derived from Apoptotic Cells and Induce a T-Cell Response

2002 ◽  
Vol 56 (3) ◽  
pp. 254-259 ◽  
Author(s):  
J. VAN ZANTEN ◽  
G. A. P. HOSPERS ◽  
M. C. HARMSEN ◽  
T. H. THE ◽  
N. H. MULDER ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Response ◽  
Viral Antigen ◽  
T Cell Response ◽  
Apoptotic Cells
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