Kinetic degradation and biocompatibility evaluation of polycaprolactone‐based biologics delivery matrices for regenerative engineering of the rotator cuff

Biocompatible chitosan–collagen–hydroxyapatite nanofibers coated with platelet-rich plasma for regenerative engineering of the rotator cuff of the shoulder

RSC Advances ◽

10.1039/c9ra03972d ◽

2019 ◽

Vol 9 (46) ◽

pp. 27013-27020 ◽

Cited By ~ 2

Author(s):

Yi Tang ◽

Hui Zhang ◽

Qinghua Wei ◽

Xu Tang ◽

Wanqiang Zhuang

Keyword(s):

Tissue Engineering ◽

Rotator Cuff ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Platelet Rich Plasma ◽

Regenerative Engineering

Over the last few decades, extraordinary progress has been accomplished in the field of bone tissue engineering.

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Regenerative Engineering of the Rotator Cuff of the Shoulder

ACS Biomaterials Science & Engineering ◽

10.1021/acsbiomaterials.7b00631 ◽

2018 ◽

Vol 4 (3) ◽

pp. 751-786 ◽

Cited By ~ 10

Author(s):

Ganesh Narayanan ◽

Lakshmi S. Nair ◽

Cato T. Laurencin

Keyword(s):

Rotator Cuff ◽

Regenerative Engineering

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Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues

MRS Advances ◽

10.1557/adv.2016.282 ◽

2016 ◽

Vol 1 (18) ◽

pp. 1255-1263 ◽

Cited By ~ 2

Author(s):

Roshan James ◽

Paulos Mengsteab ◽

Cato T. Laurencin

Keyword(s):

Developmental Biology ◽

Stem Cell ◽

Rotator Cuff ◽

Soft Tissues ◽

Cell Phenotype ◽

Cell Lineages ◽

Regenerative Engineering ◽

Tissue Systems ◽

Stem Cell Science ◽

Advanced Biomaterials

ABSTRACT‘Regenerative Engineering’ is the integration of advanced materials science, stem cell science, physics, developmental biology and clinical translation to regenerate complex tissues and organ systems. Advanced biomaterial and stem cell science converge as mechanisms to guide regeneration and the development of prescribed cell lineages from undifferentiated stem cell populations. Studies in somite development and tissue specification have provided significant insight into pathways of biological regulation responsible for tissue determination, especially morphogen gradients, and paracrine and contact-dependent signaling. The understanding of developmental biology mechanisms are shifting the biomaterial design paradigm by the incorporation of molecules into scaffold design and biomaterial development that are specifically targeted to promote the regeneration of soft tissues. Our understanding allows the selective control of cell sensitivity, and a temporal and spatial arrangement to modulate the wound healing mechanism, and the development of cell phenotype leading to the patterning of distinct and multi-scale tissue systems.Building on the development of mechanically compliant novel biomaterials, the integration of spatiotemporal control of biological, chemical and mechanical cues helps to modulate the stem cell niche and direct the differentiation of stem cell lineages. We have developed advanced biomaterials and biomimetic scaffold designs that can recapitulate the native tissue structure and mechanical compliance of soft musculoskeletal tissues, such as woven scaffold systems for ACL regeneration, non-woven scaffolds for rotator cuff tendon augmentation, and porous elastomers for regeneration of muscle tissue. Studies have clearly demonstrated the modulation of stem cell response to bulk biomaterial properties, such as toughness and elasticity, and scaffold structure, such as nanoscale and microscale dimensions. The integration of biological cues inspired from our understanding of developmental biology, along with chemical, mechanical and electrical stimulation drives our development of novel biomaterials aimed at specifying the stem cell lineage within 3-dimensional (3D) tissue systems. This talk will cover the development of biological cues, advanced biomaterials, and scaffold designs for the regeneration of complex soft musculoskeletal tissue systems such as ligament, tendon, and muscle.

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Nanofiber-based matrices for rotator cuff regenerative engineering

Acta Biomaterialia ◽

10.1016/j.actbio.2019.05.041 ◽

2019 ◽

Vol 94 ◽

pp. 64-81 ◽

Cited By ~ 13

Author(s):

Nikoo Saveh-Shemshaki ◽

Lakshmi S.Nair ◽

Cato T. Laurencin

Keyword(s):

Rotator Cuff ◽

Regenerative Engineering

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Engineered stem cell niche matrices for rotator cuff tendon regenerative engineering

PLoS ONE ◽

10.1371/journal.pone.0174789 ◽

2017 ◽

Vol 12 (4) ◽

pp. e0174789 ◽

Cited By ~ 32

Author(s):

M. Sean Peach ◽

Daisy M. Ramos ◽

Roshan James ◽

Nicole L. Morozowich ◽

Augustus D. Mazzocca ◽

...

Keyword(s):

Stem Cell ◽

Rotator Cuff ◽

Stem Cell Niche ◽

Rotator Cuff Tendon ◽

Regenerative Engineering ◽

Cell Niche

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Sleep Impairment

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2009.mayjun04 ◽

2009 ◽

Vol 14 (3) ◽

pp. 7-10

Author(s):

Craig Uejo ◽

Stephen Demeter

Keyword(s):

Rotator Cuff ◽

Distal Clavicle ◽

Rotator Cuff Disease ◽

Degenerative Arthritis ◽

Sixth Edition ◽

Cuff Tear ◽

Shoulder Region ◽

Illness Causation ◽

Traumatic Rotator Cuff Tear ◽

Distal Clavicle Resection

Abstract In the AMAGuides to the Evaluation of Permanent Impairment (AMA Guides), Sixth Edition, distal clavicle resection (resection arthroplasty of the acromioclavicular joint [ACJ]) results in ratable impairment, but only a single diagnosis within a region may be rated. Therefore, if another impairing condition is present in the shoulder region (eg, impingement syndrome or rotator cuff disease) only that resulting in the greatest causally related impairment is rated. In the setting of an occupational or other compensable injury or illness, causation of the impairment often is a key issue because, typically, only impairment that is causally related to the injury can be rated. For example, assume that a lifting injury at work caused a tear in a rotator cuff tendon that was already attenuated by repetitive impingement on inferiorly projecting spurs from longstanding degenerative arthritis of the ACJ. If surgery was performed for a traumatic rotator cuff tear and the distal clavicle also was resected due to preexisting ACJ arthritis, the latter surgery is not considered to be related to the injury. In other words, because the ACJ arthritis was neither caused nor worsened by the injury, this condition is not rated. The distal clavicular resection may have been warranted to diminish pain due to ACJ arthritis and/or eliminate the distal clavicle as a source of impingement.

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