Injectable open‐porous PLGA microspheres as cell carriers for cartilage regeneration

2021 ◽  
Author(s):  
Moyuan Qu ◽  
Xiaoling Liao ◽  
Nan Jiang ◽  
Wujin Sun ◽  
Wenqian Xiao ◽  
...  
Keyword(s):  
Cartilage Regeneration ◽  
Plga Microspheres ◽  
Cell Carriers

The use of poly(lactic-co-glycolic acid) microspheres as injectable cell carriers for cartilage regeneration in rabbit knees

2006 ◽  
Vol 17 (8) ◽  
pp. 925-939 ◽  
Author(s):  
Sun-Woong Kang ◽  
Jung-Ro Yoon ◽  
Jae-Sun Lee ◽  
Hak Jun Kim ◽  
Hee-Won Lim ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Cartilage Regeneration ◽  
Cell Carriers

Microfluidic preparation of PLGA microspheres as cell carriers with sustainable Rapa release

2019 ◽  
Vol 30 (9) ◽  
pp. 737-755 ◽  
Author(s):  
Chengcheng Zhu ◽  
Haibo Yang ◽  
Liang Shen ◽  
Zhuoyuan Zheng ◽  
Shicheng Zhao ◽  
...  
Keyword(s):  
Plga Microspheres ◽  
Cell Carriers

Study on in vitro release patterns of fentanyl-loaded PLGA microspheres

2003 ◽  
Vol 20 (5) ◽  
pp. 569-579 ◽  
Author(s):  
S.-A. Seo ◽  
G. Khang ◽  
J. M. Rhee ◽  
J. Kim ◽  
H. B. Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release

Current state of tissue engineering for cartilage regeneration

2019 ◽  
Vol XIV (2) ◽  
Author(s):  
E.E. Beketov ◽  
E.V. Isaeva ◽  
P.V. Shegay ◽  
S.A. Ivanov ◽  
A.D. Kaprin
Keyword(s):  
Tissue Engineering ◽  
Cartilage Regeneration ◽  
Current State

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials

2021 ◽  
Vol 57 (4) ◽  
pp. 166-180
Author(s):  
Maria-Minodora Marin ◽  
Madalina Georgiana Albu Kaya ◽  
George Mihail Vlasceanu ◽  
Jana Ghitman ◽  
Ionut Cristian Radu ◽  
...  
Keyword(s):  
Research Work ◽  
Cartilage Tissue Engineering ◽  
Chemical Properties ◽  
Cartilage Regeneration ◽  
Type Ii Collagen ◽  
Biomechanical Properties ◽  
Cartilage Tissue ◽  
Cross Linking ◽  
Type Ii ◽  
Crosslinking Agents

Type II collagen has been perceived as the indispensable element and plays a crucial role in cartilage tissue engineering. Thus, materials based on type II collagen have drawn farther attention in both academic and research for developing new systems for the cartilage regeneration. The disadvantage of using type II collagen as a biomaterial for tissue repairing is its reduced biomechanical properties. This can be solved by physical, enzymatic or chemical cross-linking processes, which provide biomaterials with the required mechanical properties for medical applications. To enhance type II collagen properties, crosslinked collagen scaffolds with different cross-linking agents were prepared by freeze-drying technique. The present research work studied the synthesis of type II collagen biomaterials with and without crosslinking agents. Scaffolds morphology was observed by MicroCT, showing in all cases an appropriate microstructure for biological applications, and the mechanical studies were performed using compressive tests. DSC showed an increase in denaturation temperature with an increase in cross-linking agent concentration. FTIR suggested that the secondary structure of collagen is not affected after the cross-linking; supplementary, to confirm the characteristic triple-helix conformation of collagen, the CD investigation was performed. The results showed that the physical-chemical properties of type II collagen were improved by cross-linking treatments.

Efficacy of Ropinirole-Loaded PLGA Microspheres for the Reversion of Rotenone- Induced Parkinsonism

2017 ◽  
Vol 23 (23) ◽  
Author(s):  
Sofia Negro ◽  
Liudmilla Boeva ◽  
Karla Slowing ◽  
Ana Fernandez-Carballido ◽  
Luis Garcia-García ◽  
...  
Keyword(s):  
Plga Microspheres

Cartilage Regeneration by Gene Therapy

2003 ◽  
Vol 3 (4) ◽  
pp. 305-317 ◽  
Author(s):  
K. Gelse ◽  
K. Mark ◽  
H. Schneider
Keyword(s):  
Gene Therapy ◽  
Cartilage Regeneration
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