scholarly journals Tissue response to biphasic calcium phosphate covalently modified with either heparin or hyaluronic acid in a mouse subcutaneous implantation model

2020 ◽  
Author(s):  
Sanja Stojanović ◽  
Hala AlKhoury ◽  
Milena Radenković ◽  
Vladimir Cvetković ◽  
Magdalena Jablonska ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Tissue Response ◽  
Subcutaneous Implantation ◽  
Implantation Model

Bone regeneration of multichannel biphasic calcium phosphate granules supplemented with hyaluronic acid

2019 ◽  
Vol 99 ◽  
pp. 1058-1066 ◽  
Author(s):  
Mirana Taz ◽  
Preeti Makkar ◽  
Khan Mohammad Imran ◽  
D.W. Jang ◽  
Yong-Sik Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate

Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization In Vivo Six Months after Implantation

2016 ◽  
Vol 721 ◽  
pp. 229-233 ◽  
Author(s):  
Sandris Petronis ◽  
Janis Locs ◽  
Vita Zalite ◽  
Mara Pilmane ◽  
Andrejs Skagers ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Mineralization ◽  
Bone Substitutes ◽  
Tissue Response ◽  
Control Group ◽  
Osteoporotic Bone ◽  
Local Recovery

Calcium bone substitutes are successfully used for local recovery of osteoporotic bone and filling of bone defects. Previous studies revieled that biphasic calcium phosphate (BCP) show better bioactivity in compare to pure β-tricalcium phosphate or hydroxyapatite. Also increased porosity of material promotes better bone tissue response. Aim of this experiment was to evaluate immunohistologically response of osteoporotic bone of experimental animal to implantation of granules with hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) ratio of 90/10. Calcium phosphate (CaP) was synthesized by aqueous precipitation technique from calcium hydroxide and phosphoric acid. Bioceramic granules in size range from 1.0 to 1.4 mm were prepared with nanopore sizes around 200 nm. We used nine female rabbits with induced osteoporosis in this experiment. Six animals in study group underwent implantation of BCP in hip bone defect and three animals in control group left without BCP implantation. After 6 months animals were euthanized, bone samples collected and proceeded for detection of bone activity and repair markers: osteocalcin (OC), osteopontin (OP) and osteoprotegerin (OPG). Controls showed the presence of experimental bone osteoporosis. In experimental group bone showed partially resorbed bioceramic granules and in some samples new bone formation near the granuli was observed. Increase of OC and OPG up to twice as to compare to control group were detected as well. Implantation of BCP granules in osteoporotic rabbit bone increases expression of OC and OPG indicating the activation of osteoblastogenesis and bone mineralization in vivo.

scholarly journals Injectable Silanized Hyaluronic Acid Hydrogel/Biphasic Calcium Phosphate Granule Composites with Improved Handling and Biodegradability Promote Bone Regeneration in Rabbits

2021 ◽  
Author(s):  
Killian Flegeau ◽  
Olivier Gauthier ◽  
Gildas Rethore ◽  
Florent Autrusseau ◽  
Aurelie Schaefer ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Bone Reconstruction ◽  
Hyaluronic Acid Hydrogel

Biphasic calcium phosphate (BCP) granules are osteoconductive biomaterials used in clinics to favor bone reconstruction. Yet, poor cohesivity, injectability and mechanical properties restrain their use as bone fillers. In this...

Processing and Characterization of a Composite of Hyaluronic Acid (HA) and Microspheres Biphasic Calcium Phosphate (BCP) for Dermal Repair

2012 ◽  
Vol 529-530 ◽  
pp. 421-425
Author(s):  
Edirlaine Soares Silva ◽  
Deny Gomes de Freitas ◽  
Sidney Nicodemos da Silva
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Soft Tissue ◽  
Biphasic Calcium Phosphate ◽  
Soft Tissues ◽  
Biological Response ◽  
Water Soluble ◽  
Potential Candidate ◽  
Dermal Fillers

Dermal fillers are injectable implants made of biological materials (collagen, autologous fat and hyaluronic acid animal) or synthetic (PMMA microparticles of hydroxyapatite and non-animal hyaluronic acid), biodegradable or not, that include features such as ideal biocompatibility, durability, non-profile migration and ability to promote a smooth, natural-looking correction. Its main indication is intended to treat contour defects caused by aging, photo damage, disease, trauma or scarification. The fact of biodegradable fillers are absorbed within a year after application resulted in the emergence of products permanent and semi-permanent to offer patients long-lasting effects. Currently, one of the most effective strategies has been the development of scaffolds formed by combining two or more biomaterials seeking the restoration of tissue function. The bioceramic associated with water-soluble polymers have been developed as substitutes for the repair of soft tissues with optimal biological response. The objective of this study was to process and characterize a composite hydrogel in the form of hyaluronic acid (HA) microspheres and biphasic calcium phosphate (BCP) in order injectable applications for repair of soft tissue. The powders of HA and BCP were characterized by Infrared Spectroscopy Fourier Transform (FTIR) and X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The characterization of the hydrogel injectability pure and the composite with different ratios of HA and BCP was performed. The components were characterized compatible for use as dermal fillers. The composite of hyaluronic acid (HA) and biphasic calcium phosphate (BCP) had adequate characterization and injetabilidade proving to be a potential candidate for restoration of soft tissue.

scholarly journals Ex Vivo and In Vivo Analyses of Novel 3D-Printed Bone Substitute Scaffolds Incorporating Biphasic Calcium Phosphate Granules for Bone Regeneration

2021 ◽  
Vol 22 (7) ◽  
pp. 3588
Author(s):  
Franciska Oberdiek ◽  
Carlos Ivan Vargas ◽  
Patrick Rider ◽  
Milijana Batinic ◽  
Oliver Görke ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Ex Vivo ◽  
Proper Function ◽  
New Bone Formation ◽  
3D Printed ◽  
Implantation Model

(1) Background: The aim of this study was examining the ex vivo and in vivo properties of a composite made from polycaprolactone (PCL) and biphasic calcium phosphate (BCP) (synprint, ScientiFY GmbH) fabricated via fused deposition modelling (FDM); (2) Methods: Scaffolds were tested ex vivo for their mechanical properties using porous and solid designs. Subcutaneous implantation model analyzed the biocompatibility of PCL + BCP and PCL scaffolds. Calvaria implantation model analyzed the osteoconductive properties of PCL and PCL + BCP scaffolds compared to BCP as control group. Established histological, histopathological and histomorphometrical methods were performed to evaluate new bone formation.; (3) Results Mechanical testing demonstrated no significant differences between PCL and PCL + BCP for both designs. Similar biocompatibility was observed subcutaneously for PCL and PCL + BCP scaffolds. In the calvaria model, new bone formation was observed for all groups with largest new bone formation in the BCP group, followed by the PCL + BCP group, and the PCL group. This finding was influenced by the initial volume of biomaterial implanted and remaining volume after 90 days. All materials showed osteoconductive properties and PCL + BCP tailored the tissue responses towards higher cellular biodegradability. Moreover, this material combination led to a reduced swelling in PCL + BCP; (4) Conclusions: Altogether, the results show that the newly developed composite is biocompatible and leads to successful osteoconductive bone regeneration. The new biomaterial combines the structural stability provided by PCL with bioactive characteristics of BCP-based BSM. 3D-printed BSM provides an integration behavior in accordance with the concept of guided bone regeneration (GBR) by directing new bone growth for proper function and restoration.

scholarly journals A Combination of Biphasic Calcium Phosphate (Maxresorb®) and Hyaluronic Acid Gel (Hyadent®) for Repairing Osseous Defects in a Rat Model

2020 ◽  
Vol 10 (5) ◽  
pp. 1651 ◽  
Author(s):  
Abeer G. Ahmed ◽  
Fatin A. Awartani ◽  
Abdurahman A. Niazy ◽  
John A. Jansen ◽  
Hamdan S. Alghamdi
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Rat Model ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Group I ◽  
Male Wistar Rats ◽  
Osseous Defects

The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb®, BCP) used in combination with hyaluronic acid (Hyadent®, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation.

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