The implication of the notch signaling pathway in biphasic calcium phosphate ceramic‐induced ectopic bone formation: A preliminary experiment

2020 ◽  
Vol 108 (5) ◽  
pp. 1035-1044
Author(s):  
Xiaoshuang Guo ◽  
Haiyue Jiang ◽  
Xianlei Zong ◽  
Le Du ◽  
Jingyi Zhao ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Biphasic Calcium Phosphate ◽  
Notch Signaling Pathway ◽  
Ectopic Bone Formation ◽  
Calcium Phosphate Ceramic ◽  
Ectopic Bone

Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles

Bone ◽  
2005 ◽  
Vol 36 (6) ◽  
pp. 1086-1093 ◽  
Author(s):  
D LENIHOUANNEN ◽  
G DACULSI ◽  
A SAFFARZADEH ◽  
O GAUTHIER ◽  
S DELPLACE ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Ectopic Bone Formation ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Particles ◽  
Ectopic Bone

Ectopic Bone Formation in Titanium Mesh Loaded with Bone Morphogenetic Protein and Coated with Calcium Phosphate

2001 ◽  
Vol 108 (2) ◽  
pp. 434-443 ◽  
Author(s):  
Johan W. M. Vehof ◽  
Javed Mahmood ◽  
Hiroko Takita ◽  
Martin A. vanʼt Hof ◽  
Yoshinori Kuboki ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Ectopic Bone Formation ◽  
Titanium Mesh ◽  
Morphogenetic Protein ◽  
Ectopic Bone

scholarly journals Coralline Hydroxyapatite Coated with a Layer Biomimetic Calcium Phosphate Containing BMP-2 Induces Dose-Related Ectopic Bone Formation in Wistar Rats

Coatings ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1195
Author(s):  
Henri J. J. Uijlenbroek ◽  
Xingnan Lin ◽  
Xin Zhang ◽  
Liquan Deng ◽  
Daniel Wismeijer ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Wistar Rats ◽  
Ectopic Bone Formation ◽  
Bone Morphogenetic Protein 2 ◽  
Ectopic Bone ◽  
Coralline Hydroxyapatite ◽  
Male Wistar Rats ◽  
Loading Methods ◽  
Histological Results

In order to evaluate loading methods and the dose dependency of bone morphogenetic protein 2 (BMP-2) in ectopic bone formation, an osteoinductive material consisting of commercially available coralline hydroxyapatite (CHA) was coated with a layer of biomimetic calcium phosphate (BioCaP) containing BMP-2 in different ways. Eight groups—each containing samples of 0.25 g CHA—were formed and coated with, respectively, BioCaP with internally incorporated BMP-2 in concentrations of 1, 5, 10, 20, 40 and 60 µg per sample, and the two control groups with BioCaP only and BioCaP with 20 µg of adsorbed BMP-2 per sample. The samples were implanted subcutaneously in 27 male Wistar rats. The histological results show that there is no bone formation in the group in which no BMP-2 was included. All samples with BioCaP containing BMP-2 show bone formation. The group with 20 µg of adsorbed BMP-2 per sample shows the least bone formation. Coating-incorporated BMP-2 is more efficient in inducing bone formation than adsorbed BMP-2. The group with 5 µg of coating-incorporated BMP-2 per sample shows the most bone formation. Increasing the amount of coating-incorporated BMP-2 up to 60 µg does not improve ectopic bone formation.

Exercise enhance the ectopic bone formation of calcium phosphate biomaterials in muscles of mice

2017 ◽  
Vol 77 ◽  
pp. 136-141 ◽  
Author(s):  
Lijia Cheng ◽  
Shuo Yan ◽  
Jiang Zhu ◽  
Peiling Cai ◽  
Ting Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Ectopic Bone Formation ◽  
Ectopic Bone
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