Novel dual‐responsive semi‐interpenetrating polymer network hydrogels for controlled release of anticancer drugs

2019 ◽  
Vol 107 (10) ◽  
pp. 2327-2339 ◽  
Author(s):  
Seyed Mohammad Reza Dadfar ◽  
Saeed Pourmahdian ◽  
Mohammad Mehdi Tehranchi ◽  
Seyed Mohammadali Dadfar
Keyword(s):  
Controlled Release ◽  
Anticancer Drugs ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Dual Responsive

scholarly journals Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Jingqiong Lu ◽  
Yinhui Li ◽  
Deng Hu ◽  
Xiaoling Chen ◽  
Yongmei Liu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Aspartic Acid ◽  
Vinyl Alcohol ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Simulated Gastric Fluid ◽  
Poly Vinyl Alcohol ◽  
Simulated Intestinal Fluid ◽  
Swelling Properties ◽  
Drug Controlled Release

Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application

2012 ◽  
Vol 50 (1) ◽  
pp. 198-206 ◽  
Author(s):  
Subham Banerjee ◽  
Lubna Siddiqui ◽  
Shiv Sankar Bhattacharya ◽  
Santanu Kaity ◽  
Animesh Ghosh ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Hydrogel Microspheres

Development of chitosan-guar gum semi-interpenetrating polymer network microspheres for controlled release of cefadroxil

2006 ◽  
Vol 9 (5) ◽  
pp. 491-501 ◽  
Author(s):  
K. Mallikarjuna Reddy ◽  
V. Ramesh Babu ◽  
M. Sairam ◽  
M. C. S. Subha ◽  
N. N. Mallikarjuna ◽  
...  
Keyword(s):  
Controlled Release ◽  
Guar Gum ◽  
Polymer Network ◽  
Interpenetrating Polymer Network
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