Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

2019 ◽  
Vol 107 (7) ◽  
pp. 1551-1562 ◽  
Author(s):  
Serena Del Turco ◽  
Gianni Ciofani ◽  
Valentina Cappello ◽  
Paola Parlanti ◽  
Mauro Gemmi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cerium Oxide ◽  
Vascular Endothelial Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Vascular Endothelial

scholarly journals Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells

2009 ◽  
Vol 21 (sup1) ◽  
pp. 123-130 ◽  
Author(s):  
Andrea Gojova ◽  
Jun-Tae Lee ◽  
Heejung S. Jung ◽  
Bing Guo ◽  
Abdul I. Barakat ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cerium Oxide ◽  
Vascular Endothelial Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Vascular Endothelial

scholarly journals Induction of Inflammation in Vascular Endothelial Cells by Metal Oxide Nanoparticles: Effect of Particle Composition

2007 ◽  
Vol 115 (3) ◽  
pp. 403-409 ◽  
Author(s):  
Andrea Gojova ◽  
Bing Guo ◽  
Rama S. Kota ◽  
John C. Rutledge ◽  
Ian M. Kennedy ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Metal Oxide ◽  
Vascular Endothelial Cells ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Vascular Endothelial ◽  
Particle Composition

Cerium Oxide Nanoparticles Protect Endothelial Cells from Apoptosis Induced by Oxidative Stress

2013 ◽  
Vol 154 (1) ◽  
pp. 156-166 ◽  
Author(s):  
Shizhu Chen ◽  
Yingjian Hou ◽  
Gong Cheng ◽  
Cuimiao Zhang ◽  
Shuxiang Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Oxidative Stress Boosts the Uptake of Cerium Oxide Nanoparticles by Changing Brain Endothelium Microvilli Pattern

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 266
Author(s):  
Roberta Dal Magro ◽  
Agostina Vitali ◽  
Stefano Fagioli ◽  
Alberto Casu ◽  
Andrea Falqui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Cerium Oxide ◽  
Amyloid Β ◽  
Cerium Oxide Nanoparticles ◽  
Antioxidant Compounds ◽  
Oxide Nanoparticles ◽  
Amyloid Β Peptide ◽  
Potent Inducer ◽  
Therapeutic Benefits

Vascular oxidative stress is considered a worsening factor in the progression of Alzheimer’s disease (AD). Increased reactive oxygen species (ROS) levels promote the accumulation of amyloid-β peptide (Aβ), one of the main hallmarks of AD. In turn, Aβ is a potent inducer of oxidative stress. In early stages of AD, the concomitant action of oxidative stress and Aβ on brain capillary endothelial cells was observed to compromise the blood–brain barrier functionality. In this context, antioxidant compounds might provide therapeutic benefits. To this aim, we investigated the antioxidant activity of cerium oxide nanoparticles (CNP) in human cerebral microvascular endothelial cells (hCMEC/D3) exposed to Aβ oligomers. Treatment with CNP (13.9 ± 0.7 nm in diameter) restored basal ROS levels in hCMEC/D3 cells, both after acute or prolonged exposure to Aβ. Moreover, we found that the extent of CNP uptake by hCMEC/D3 was +43% higher in the presence of Aβ. Scanning electron microscopy and western blot analysis suggested that changes in microvilli structures on the cell surface, under pro-oxidant stimuli (Aβ or H2O2), might be involved in the enhancement of CNP uptake. This finding opens the possibility to exploit the modulation of endothelial microvilli pattern to improve the uptake of anti-oxidant particles designed to counteract ROS-mediated cerebrovascular dysfunctions.

scholarly journals Anti-inflammatory and antioxidant effects of cerium oxide nanoparticles in human endothelial cells

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4174-P4174 ◽  
Author(s):  
S. Del Turco ◽  
G. Ciofani ◽  
V. Cappello ◽  
T. Navarra ◽  
C. Caselli ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Human Endothelial Cells ◽  
Anti Inflammatory ◽  
Antioxidant Effects
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