scholarly journals Protein/polysaccharide-based scaffolds mimicking native extracellular matrix for cardiac tissue engineering applications

2017 ◽  
Vol 106 (3) ◽  
pp. 769-781 ◽  
Author(s):  
Elisabetta Rosellini ◽  
Yu Shrike Zhang ◽  
Bianca Migliori ◽  
Niccoletta Barbani ◽  
Luigi Lazzeri ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Engineering Applications

scholarly journals Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 386
Author(s):  
Ana Santos ◽  
Yongjun Jang ◽  
Inwoo Son ◽  
Jongseong Kim ◽  
Yongdoo Park
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Computational Modeling ◽  
Cardiac Tissue ◽  
Cardiac Development ◽  
Heart Tissue ◽  
Cardiac Tissue Engineering ◽  
Cardiac Cells

Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering.

Gelatin electrospun nanofibrous matrices for cardiac tissue engineering applications

2016 ◽  
Vol 66 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Anuradha Elamparithi ◽  
Alan M. Punnoose ◽  
Solomon F. D. Paul ◽  
Sarah Kuruvilla
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Engineering Applications

scholarly journals Native cardiac environment and its impact on engineering cardiac tissue

2019 ◽  
Vol 7 (9) ◽  
pp. 3566-3580 ◽  
Author(s):  
Verena Schwach ◽  
Robert Passier
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Embryonic Development ◽  
Human Heart ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Adult Human ◽  
Natural And Synthetic

In this review, we describe the progressive build-up of the cardiac extracellular matrix (ECM) during embryonic development, the ECM of the adult human heart and the application of natural and synthetic biomaterials for cardiac tissue engineering using hPSC-CMs.

Vascularisation for cardiac tissue engineering: the extracellular matrix

2015 ◽  
Vol 113 (03) ◽  
pp. 532-547 ◽  
Author(s):  
Chinmoy Patra ◽  
Aldo Boccaccini ◽  
Felix Engel
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cardiac Tissue ◽  
Heart Diseases ◽  
Cardiac Tissue Engineering ◽  
Promising Candidate ◽  
Realistic Option ◽  
Extracellular Matrix Molecules ◽  
Heart Muscle Cells

SummaryCardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs to be compensated. A promising approach to this issue is cardiac tissue engineering. In this review we focus on the problem of in vitro vascularisation as implantation of cardiac patches consisting of more than three layers of cardiomyocytes (> 100 μm thick) already results in necrosis. We explain the need for vascularisation and elaborate on the importance to include non-myocytes in order to generate functional vascularised cardiac tissue. We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an example of a new promising candidate. Finally, we discuss current biomaterial- based approaches including micropatterning, electrospinning, 3D micro-manufacturing technology and porogens. Collectively, the current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.

Blood compatibility and physicochemical assessment of novel nanocomposite comprising polyurethane and dietary carotino oil for cardiac tissue engineering applications

2017 ◽  
Vol 135 (3) ◽  
pp. 45691 ◽  
Author(s):  
Saravana Kumar Jaganathan ◽  
Mohan Prasath Mani ◽  
Manikandan Ayyar ◽  
Navaneetha Pandiyaraj Krishnasamy ◽  
Gomathi Nageswaran
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Blood Compatibility ◽  
Cardiac Tissue Engineering ◽  
Engineering Applications

Biodegradable methacrylated casein for cardiac tissue engineering applications

2021 ◽  
Vol 9 (6) ◽  
pp. 1557-1567
Author(s):  
Sonali Sudhir Sali ◽  
Maree L. Gould ◽  
Muhammad Qasim ◽  
M. Azam Ali
Keyword(s):  
Tissue Engineering ◽  
Chemical Modification ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Engineering Applications ◽  
Potential Applications ◽  
Commercial Milk ◽  
Dissolved Air

Novel chemical modification of dissolved air floatation casein and commercial milk for potential applications in cardiac tissue engineering.

scholarly journals Optimisation of conductive polymer biomaterials for cardiac progenitor cells

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62270-62277 ◽  
Author(s):  
C. Puckert ◽  
A. Gelmi ◽  
M. K. Ljunggren ◽  
M. Rafat ◽  
E. W. H. Jager
Keyword(s):  
Tissue Engineering ◽  
Cardiac Function ◽  
Progenitor Cells ◽  
Cardiac Tissue ◽  
Conductive Polymer ◽  
Cardiac Tissue Engineering ◽  
Cardiac Progenitor Cells ◽  
Engineering Applications ◽  
Effective Treatments

The characterisation of biomaterials for cardiac tissue engineering applications is vital for the development of effective treatments for the repair of cardiac function.

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