Low-thrombogenic fibrin-heparin coating promotesin vitroendothelialization

2017 ◽  
Vol 105 (11) ◽  
pp. 2995-3005 ◽  
Author(s):  
Ondřej Kaplan ◽  
Teresa Hierlemann ◽  
Stefanie Krajewski ◽  
Julia Kurz ◽  
Martina Nevoralová ◽  
...  
Keyword(s):  
Heparin Coating

1450: Double J Stent with Synthetic Heparin Coating does not Prevent Biofilm Deposit and Mineral Incrustation in Comparison with Standard Double J Stent

2007 ◽  
Vol 177 (4S) ◽  
pp. 479-479
Author(s):  
Frédéric Thibault ◽  
Michel Daudon ◽  
Bernard Gattegno ◽  
Olivier Traxer
Keyword(s):  
Heparin Coating ◽  
Double J Stent

Antithrombin III Binding to Surface Immobilized Heparin and Its Relation to F Xa Inhibition

1987 ◽  
Vol 58 (04) ◽  
pp. 1064-1067 ◽  
Author(s):  
K Kodama ◽  
B Pasche ◽  
P Olsson ◽  
J Swedenborg ◽  
L Adolfsson ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ionic Strength ◽  
Surface Coating ◽  
Antithrombin Iii ◽  
Lower Class ◽  
Biologically Active ◽  
High Affinity ◽  
Heparin Coating ◽  
Continuous Surface ◽  
Approximate Molecular Weight

SummaryThe mode of F Xa inhibition was investigated on a thromboresistant surface with end-point attached partially depoly-merized heparin of an approximate molecular weight of 8000. Affinity chromatography revealed that one fourth of the heparin used in surface coating had high affinity for antithrombin III (AT). The heparin surface adsorbed AT from both human plasma and solutions of purified AT. By increasing the ionic strength in the AT solution the existence of high and low affinity sites could be shown. The uptake of AT was measured and the density of available high and low affinity sites was found to be in the range of 5 HTid 11 pic.omoles/cmf, respectively Thus the estimated density of biologically active high and low ailmity heparm respectively would be 40 and 90 ng/cm2 The heparin coating did not take up or exert F Xa inhibition by itself. With AT adsorbed on both high and low affinity heparin the surface had the capacity to inhibit several consecutive aliquots of F Xa exposed to the surface. When mainly high affinity sites were saturated with AT the inhibition capacity was considerably lower. Tt was demonstrated that the density of AT on both high and low affinity heparin determines the F Xa inhibition capacity whereas the amount of AT on high affinity sites limits the rate of the reaction. This implies that during the inhibition of F Xa there is a continuous surface-diffusion of AT from sites of a lower class to the high affinity sites where the F Xa/AT complex is formed and leaves the surface. The ability of the immobilized heparin to catalyze inhibition of F Xa is likely to be an important component for the thromboresistant properties of a heparin coating with non-compromized AT binding sequences.

A comparison of radiographic signs of pulmonary inflammation during ECMO between silicon and poly-methyl pentene oxygenators

Perfusion ◽  
2007 ◽  
Vol 22 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Espeed Khoshbin ◽  
Anthony EW Dux ◽  
Hilliary Killer ◽  
Andrzej W Sosnowski ◽  
Richard K Firmin ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Quantitative Methods ◽  
Inflammatory Process ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Pulmonary Inflammation ◽  
Delayed Response ◽  
Heparin Coating ◽  
Percentage Survival ◽  
Inflammatory Changes

Introduction: The inflammatory response caused by extracorporeal membrane oxygenation (ECMO) is clearly visible within the first 24 h of cannulation. The inflammatory process affects all areas of the lung, even areas previously spared by the primary disease. Objective: To compare the change in the radiographic signs of inflammatory response to ECMO between poly-methyl pentene and silicon oxygenators. Study design: Retrospective review of neonates and adults pre- and post-replacement of silicon oxygenators with poly-methyl pentene devices. Data were collected from Extracorporeal Life Support Organisation (ELSO) registry forms and patient records. Results were analysed by quantitative and semi-quantitative methods. Results: There was a significant reduction in the radiographic signs of inflammatory response to ECMO, and a reduction in the time taken to revert to pre-ECMO state in the neonatal poly-methyl pentene group compared to silicon. However, there was no significant reduction in the duration of ECMO runs and the percentage survival between these groups in the neonates. In adults, there was no difference in severity of radiographic signs between groups. However, the inflammatory changes were relatively delayed in the adult poly-methyl pentene group. Conclusion: Poly-methyl pentene (Medos) oxygenators have reduced the host's response phenomenon `white out' in neonates, and caused a delayed response in adults. This is most likely a consequence of smaller blood contact surface area combined with the effect of heparin coating of the oxygenator membrane. However, recovery was not a function of the type of gas exchange device used. Perfusion (2007) 22, 15-21.

scholarly journals Heparin coating reduces cell activation and mediator release in an in vitro venovenous bypass model for liver transplantation

1998 ◽  
Vol 11 (4) ◽  
pp. 252-258 ◽  
Author(s):  
Rigmor Solberg ◽  
Tim Scholz ◽  
Vibeke Videm ◽  
Cecilie Okkenhaug ◽  
Ansgar O. Aasen
Keyword(s):  
Liver Transplantation ◽  
Cell Activation ◽  
Mediator Release ◽  
Venovenous Bypass ◽  
Heparin Coating

COMPARATIVE STUDY OF SURFACE BLOOD INTERACTION TO CARDIOPULMONARY BYPASS CIRCUIT WITH OR WITHOUT HEPARIN-COATING

ASAIO Journal ◽  
1996 ◽  
Vol 42 (2) ◽  
pp. 64
Author(s):  
F. Fukumura ◽  
A. Nakashima ◽  
Y. Tomita ◽  
Y. Toshima ◽  
Y. Imoto ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Comparative Study ◽  
Heparin Coating

An Internet-based registry examining the efficacy of heparin coating in patients undergoing coronary stent implantation

2005 ◽  
Vol 150 (6) ◽  
pp. 1171-1176 ◽  
Author(s):  
Roxana Mehran ◽  
Eugenia Nikolsky ◽  
Edoardo Camenzind ◽  
Michael Zelizko ◽  
Igor Kranjec ◽  
...  
Keyword(s):  
Stent Implantation ◽  
Coronary Stent ◽  
Heparin Coating ◽  
Coronary Stent Implantation
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