A novel technique for decellularization of allogenic nerves and in vivo study of their use for peripheral nerve reconstruction

2017 ◽  
Vol 105 (8) ◽  
pp. 2228-2240 ◽  
Author(s):  
F. Boriani ◽  
N. Fazio ◽  
C. Fotia ◽  
L. Savarino ◽  
N. Nicoli Aldini ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
In Vivo Study ◽  
Nerve Reconstruction ◽  
Novel Technique

scholarly journals Gellan Gum-based luminal fillers for peripheral nerve regeneration: an in vivo study in the rat sciatic nerve repair model

2018 ◽  
Vol 6 (5) ◽  
pp. 1059-1075 ◽  
Author(s):  
C. R. Carvalho ◽  
S. Wrobel ◽  
C. Meyer ◽  
C. Brandenberger ◽  
I. F. Cengiz ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Experimental Work ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Gellan Gum ◽  
In Vivo Study ◽  
Rat Sciatic Nerve

This experimental work considers the innovative use of the biomaterial Gellan Gum (GG) as a luminal filler for nerve guidance channels.

Novel technique for peripheral nerve reconstruction in the absence of an artificial conduit

2004 ◽  
Vol 134 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Takatsugu Komiyama ◽  
Yasushi Nakao ◽  
Yoshiaki Toyama ◽  
Charles A. Vacanti ◽  
Martin P. Vacanti ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Reconstruction ◽  
Novel Technique

In Vivo Survival of Mesenchymal Stromal Cell–Enhanced Decellularized Nerve Grafts for Segmental Peripheral Nerve Reconstruction

2019 ◽  
Vol 44 (6) ◽  
pp. 514.e1-514.e11 ◽  
Author(s):  
Nadia Rbia ◽  
Liselotte F. Bulstra ◽  
Roman Thaler ◽  
Steven E.R. Hovius ◽  
Andre J. van Wijnen ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Nerve Reconstruction ◽  
Nerve Grafts

Cell-Enhanced Acellular Nerve Allografts for Peripheral Nerve Reconstruction: A Systematic Review and a Meta-Analysis of the Literature

Neurosurgery ◽  
2018 ◽  
Vol 85 (5) ◽  
pp. 575-604 ◽  
Author(s):  
Francesca Alice Pedrini ◽  
Filippo Boriani ◽  
Federico Bolognesi ◽  
Nicola Fazio ◽  
Claudio Marchetti ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Case Reports ◽  
Case Series ◽  
Future Research ◽  
Nerve Reconstruction ◽  
Level Of Evidence ◽  
Promising Alternative ◽  
Positive Effects

Abstract BACKGROUND Peripheral nerve reconstruction is a difficult problem to solve. Acellular nerve allografts (ANAs) have been widely tested and are a promising alternative to the autologous gold standard. However, current reconstructive methods still yield unpredictable and unsuccessful results. Consequently, numerous studies have been carried out studying alternatives to plain ANAs, but it is not clear if nerve regeneration potential exists between current biological, chemical, and physical enrichment modes. OBJECTIVE To systematically review the effects of cell-enhanced ANAs on regeneration of peripheral nerve injuries. METHODS PubMed, ScienceDirect, Medline, and Scopus databases were searched for related articles published from 2007 to 2017. Inclusion criteria of selected articles consisted of (1) articles written in English; (2) the topic being cell-enhanced ANAs in peripheral nerve regeneration; (3) an in vivo study design; and (4) postgrafting neuroregenerative assessment of results. Exclusion criteria included all articles that (1) discussed central nervous system ANAs; (2) consisted of xenografts as the main topic; and (3) consisted of case series, case reports or reviews. RESULTS Forty papers were selected, and categorization included the animal model; the enhancing cell types; the decellularization method; and the neuroregenerative test performed. The effects of using diverse cellular enhancements combined with ANAs are discussed and also compared with the other treatments such as autologous nerve graft, and plain ANAs. CONCLUSION ANAs cellular enhancement demonstrated positive effects on recovery of nerve function. Future research should include clinical translation, in order to increase the level of evidence available on peripheral nerve reconstruction.

Peripheral nerve regeneration in rats by chitosan/alginate hydrogel composited with Berberine and Naringin nanoparticles: in vitro and in vivo study

2020 ◽  
Vol 318 ◽  
pp. 114226 ◽  
Author(s):  
Mohammad Hossein Ebrahimi ◽  
Hadi Samadian ◽  
Shiva Tavakol Davani ◽  
Nariman Rezaei Kolarijani ◽  
Nasser Mogharabian ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
In Vivo Study ◽  
Alginate Hydrogel
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