Collagen/heparin sulfate scaffolds fabricated by a 3D bioprinter improved mechanical properties and neurological function after spinal cord injury in rats

2017 ◽  
Vol 105 (5) ◽  
pp. 1324-1332 ◽  
Author(s):  
Chong Chen ◽  
Ming-liang Zhao ◽  
Ren-kun Zhang ◽  
Gang Lu ◽  
Chang-yu Zhao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Function ◽  
Heparin Sulfate ◽  
Cord Injury

Passive mechanical properties of the gastrocnemius after spinal cord injury

2012 ◽  
Vol 46 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Joanna H.L. Diong ◽  
Robert D. Herbert ◽  
Lisa A. Harvey ◽  
Li Khim Kwah ◽  
Jillian L. Clarke ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury

Course 510: Spinal cord injury: Changes of the Skin Mechanical Properties After Spinal Cord Injury

2008 ◽  
Vol 89 (11) ◽  
pp. e13-e14
Author(s):  
Ji Woong Park ◽  
Ki-Un Jang ◽  
Hyuck Lee ◽  
Ju Yun Lee ◽  
Yang Gyun Lee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury

Beneficial effects of nitric oxide synthase inhibition on the recovery of neurological function after spinal cord injury in rats

2001 ◽  
Vol 363 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Toshio Suzuki ◽  
Hozumi Tatsuoka ◽  
Tanemichi Chiba ◽  
Toshihiko Sekikawa ◽  
Tetsuharu Nemoto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nitric Oxide Synthase ◽  
Neurological Function ◽  
Beneficial Effects ◽  
Cord Injury ◽  
Oxide Synthase

scholarly journals The spinal cord-gut-immune axis as a master regulator of health and neurological function after spinal cord injury

2020 ◽  
Vol 323 ◽  
pp. 113085 ◽  
Author(s):  
Kristina A. Kigerl ◽  
Kylie Zane ◽  
Kia Adams ◽  
Matthew B. Sullivan ◽  
Phillip G. Popovich
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Function ◽  
Master Regulator ◽  
Cord Injury

Late neurological changes following traumatic spinal cord injury

1988 ◽  
Vol 69 (3) ◽  
pp. 399-402 ◽  
Author(s):  
Joseph M. Piepmeier ◽  
N. Ross Jenkins
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Cord Injuries ◽  
Neurological Status ◽  
Neurological Function ◽  
Traumatic Spinal Cord Injury ◽  
Content Type ◽  
Cord Injury ◽  
Fine Print

✓ Sixty-nine patients with traumatic spinal cord injuries were evaluated for changes in their functional neurological status at discharge from the hospital, and at 1 year, 3 years, and 5+ years following injury. The neurological examinations were used to classify patients' spinal cord injury according to the Frankel scale. This analysis revealed that the majority of improvement in neurological function occurred within the 1st year following injury; however, changes in the patients' status continued for many years. Follow-up examinations at an average of 3 years postinjury revealed that 23.3% of the patients continued to improve, whereas 7.1% had deteriorated compared to their status at 1 year. An examination at an average of 5+ years demonstrated further improvement in 12.5%, with 5.0% showing deterioration compared to the examinations at 3 years. These results demonstrate that, in patients with spinal trauma, significant changes in neurological function continue for many years.

Coadministration of Methylprednisolone with Hypertonic Saline Solution Improves Overall Neurological Function and Survival Rates in a Chronic Model of Spinal Cord Injury

Neurosurgery ◽  
2001 ◽  
Vol 49 (6) ◽  
pp. 1427-1433 ◽  
Author(s):  
Jeffrey J. Legos ◽  
Kurt R. Gritman ◽  
Ronald F. Tuma ◽  
William F. Young
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Hypertonic Saline ◽  
Intravenous Injection ◽  
Rating Scale ◽  
Survival Rates ◽  
Isotonic Saline ◽  
Neurological Function ◽  
Control Group ◽  
Cord Injury

ABSTRACT OBJECTIVE We previously demonstrated that administration of 7.5% hypertonic saline (HS) significantly improved spinal cord blood flow and neurological outcomes after spinal cord injury. The aim of this study was to determine whether hypertonicity would enhance the effects of methylprednisolone (MP), further improving neurological function. METHODS Rat spinal cords were compressed for 10 minutes with 50 g of weight, and neurological function was assessed for 28 days, using the Basso-Beattie-Bresnahan locomotor rating scale. The control group received an intravenous injection of isotonic saline (IS) (5 ml/kg). Group 1 received an intravenous injection of 7.5% HS (5 ml/kg). Group 2 received an intravenous injection of MP (30 mg/kg) and IS (5 ml/kg). Group 3 received an intravenous injection of MP (30 mg/kg) administered with 7.5% HS (5 ml/kg). RESULTS At 24 hours after spinal cord injury, the combination of MP plus HS provided significant (P < 0.01) neurological improvements, compared with all other treatment groups. At 10 days after injury, the animals that had received MP plus HS exhibited significantly (P < 0.01) higher Basso-Beattie-Bresnahan scores, compared with the MP plus IS and control groups. The median survival time was significantly (P < 0.01) increased for the MP plus HS group (28 d), compared with the MP plus IS group (16 d). Because of the dramatic decrease in survival rates at 28 days after injury, there was a significant (P < 0.01) difference in neurological function only between the MP plus HS group and the control group. CONCLUSION The results indicate that the administration of HS may enhance the delivery of MP and prevent immunosuppression, leading to improvements in overall neurological function and survival rates after spinal cord injury.

Sign in / Sign up

Export Citation Format

Share Document