Multinucleated giant cells in the implant bed of bone substitutes are foreign body giant cells-New insights into the material-mediated healing process

2017 ◽  
Vol 105 (4) ◽  
pp. 1105-1111 ◽  
Author(s):  
Mike Barbeck ◽  
Patrick Booms ◽  
Ronald Unger ◽  
Verena Hoffmann ◽  
Robert Sader ◽  
...  
Keyword(s):  
Foreign Body ◽  
Healing Process ◽  
Bone Substitutes ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Foreign Body Giant Cells ◽  
Implant Bed

scholarly journals Pulse Granulomas of the Gastrointestinal Tract and Gallbladder: Report of Five Cases

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Tom C. DeRoche ◽  
Gregory A. Gates ◽  
Aaron R. Huber
Keyword(s):  
Gastrointestinal Tract ◽  
Foreign Body ◽  
Incidental Finding ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Ultrastructural Studies ◽  
Foreign Body Giant Cells ◽  
Edible Seeds ◽  
Mass Lesions ◽  
Vegetable Material

Hyaline rings with admixed multinucleated giant cells characterize pulse granulomas; the term pulse refers to edible seeds of legume vegetables. The etiology has been controversial, with theories including vascular degenerative changes or a reaction to vegetable material; ultrastructural studies and experimentally induced lesions in animals favor the latter. This lesion is typically seen in the oral cavity, with only rare reports in the gastrointestinal tract and gallbladder. We herein describe five cases of pulse granulomas identified in these sites. All cases contained foreign-body giant cells and vegetable debris within or near hyaline rings. Pulse granulomas may form mass lesions but are usually an incidental finding on microscopic examination. In incidentally detected cases, recognition of pulse granulomas can suggest a mural abscess, fistula, or perforation of the gut, findings which may not be grossly apparent. The presence of vegetable material in all five cases further supports an exogenous pathogenesis.

TRAP-Positive Multinucleated Giant Cells Are Foreign Body Giant Cells Rather Than Osteoclasts: Results From a Split-Mouth Study in Humans

2015 ◽  
Vol 41 (6) ◽  
pp. e257-e266 ◽  
Author(s):  
Jonas Lorenz ◽  
Alica Kubesch ◽  
Tadas Korzinskas ◽  
Mike Barbeck ◽  
Constantin Landes ◽  
...  
Keyword(s):  
Foreign Body ◽  
Connective Tissue ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Giant Cells ◽  
Tissue Response ◽  
Multinucleated Giant Cells ◽  
Bone Substitute Material ◽  
Foreign Body Giant Cells ◽  
Substitute Material

This study compared the material-specific tissue response to the synthetic, hydroxyapatite-based bone substitute material NanoBone (NB) with that of the xenogeneic, bovine-based bone substitute material Bio-Oss (BO). The sinus cavities of 14 human patients were augmented with NB and BO in a split-mouth design. Six months after augmentation, bone biopsies were extracted for histological and histomorphometric investigation prior to dental implant insertion. The following were evaluated: the cellular inflammatory pattern, the induction of multinucleated giant cells, vascularization, the relative amounts of newly formed bone, connective tissue, and the remaining bone substitute material. NB granules were well integrated in the peri-implant tissue and were surrounded by newly formed bone tissue. Multinucleated giant cells were visible on the surfaces of the remaining granules. BO granules were integrated into the newly formed bone tissue, which originated from active osteoblasts on their surface. Histomorphometric analysis showed a significantly higher number of multinucleated giant cells and blood vessels in the NB group compared to the BO group. No statistical differences were observed in regard to connective tissue, remaining bone substitute, and newly formed bone. The results of this study highlight the different cellular reactions to synthetic and xenogeneic bone substitute materials. The significantly higher number of multinucleated giant cells within the NB implantation bed seems to have no effect on its biodegradation. Accordingly, the multinucleated giant cells observed within the NB implantation bed have characteristics more similar to those of foreign body giant cells than to those of osteoclasts.

Pulmonary hair embolism in a rescued free-ranging Eurasian otter Lutra lutra in Kinmen, Taiwan

2020 ◽  
Vol 142 ◽  
pp. 55-61
Author(s):  
WT Li ◽  
YL Chiang ◽  
TY Chen ◽  
CL Lai
Keyword(s):  
Foreign Body ◽  
Traumatic Injury ◽  
Lung Parenchyma ◽  
Giant Cells ◽  
Hair Shaft ◽  
Lutra Lutra ◽  
Lung Lobe ◽  
Eurasian Otter ◽  
Foreign Body Giant Cells ◽  
Free Ranging

Eurasian otters Lutra lutra are listed as Near Threatened on the IUCN Red List and are imperiled by habitat loss, water pollution, and poaching. Harassment and attacks by stray animals are also recognized threats to the health of wild Eurasian otters. Pulmonary hair embolism is a possible complication in animals with deep traumatic injury, but to date no cases have been reported in wildlife. A free-ranging, adult male Eurasian otter was rescued due to severe emaciation and multiple bite wounds. The otter died 3 d after rescue and was necropsied. Grossly, a 1.5 × 1.5 × 1.5 cm firm nodule was observed in the left cranial lung lobe. Histologically, a fragment of hair shaft surrounded by multinucleated foreign body giant cells was observed in a medium-sized vein, and extensive eosinophilic infiltration was noted in the adjacent vascular wall and lung parenchyma. Based on the gross and histological findings, the pulmonary lesion was consistent with eosinophilic pneumonia and vasculitis induced by hair embolism. The presence of well-formed multinucleated foreign body giant cells and eosinophils may imply a late stage of foreign body reaction, and thus the presumptive source of hair embolism is an animal bite. This is the first report of pulmonary hair embolism associated with animal bite in a rescued free-ranging Eurasian otter.

Comparison of bone wax and chitosan usage on post-sternotomy bone healing

2020 ◽  
pp. 021849232098409
Author(s):  
Ihsanul Amal ◽  
Heroe Soebroto ◽  
Puruhito
Keyword(s):  
Foreign Body ◽  
Bone Healing ◽  
Postoperative Bleeding ◽  
Giant Cells ◽  
Operative Field ◽  
Inflammatory Reactions ◽  
Foreign Body Giant Cells ◽  
New Zealand White Rabbits ◽  
Affect Bone Healing ◽  
Chitosan Powder

Background Sternotomy is a standard approach performed in almost every surgical procedure on the heart and mediastinum. Effective hemostasis of the sternum is required to keep the operative field dry, avoid excessive blood transfusions during surgery, and prevent reoperation due to massive postoperative bleeding, which can further increase morbidity and mortality in patients. Bone wax is a mechanical hemostat commonly used after sternotomy and has been known to affect bone healing, trigger chronic inflammatory reactions, and increase the rate of infection. The application of chitosan, which has intrinsic hemostat ability, as hemostatic material is believed to improve bone healing following sternotomy. This study aimed to compare the effectiveness of bone wax and chitosan on bone healing after sternotomy. Methods Median sternotomies were performed on 2 groups of New Zealand White rabbits. Each group of 16 animals received either bone wax or chitosan powder as hemostatic material. The degree of bone healing, the number of foreign-body giant cells, and the number of osteoblasts were evaluated after 6 weeks. Results Radiographs showed that significantly more animals in the chitosan group had total sternal healing ( p = 0.033). Histopathology revealed that the number of foreign-body giant cells was significantly less ( p = 0.036) and the number of osteoblasts was significantly greater ( p < 0.0001) in the group of animals that received chitosan. Conclusion The use of chitosan as hemostatic material can promote better bone healing compared to bone wax.

Are Langhans giant cells precursors of foreign-body giant cells?

1978 ◽  
Vol 263 (1) ◽  
pp. 13-21 ◽  
Author(s):  
H. J. van der Rhee ◽  
W. Hillebrands ◽  
W. Th. Daems
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

The transformation of langhans giant cells into foreign body giant cells

1979 ◽  
Vol 4 (1) ◽  
pp. 147
Author(s):  
H.J. van der Rhee ◽  
C.P.M. van der Burgh-de Winter ◽  
W.Th. Daems
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells

1991 ◽  
Vol 96 (2) ◽  
pp. 169-176 ◽  
Author(s):  
J. M. W. Quinn ◽  
N. A. Athanasou ◽  
J.O'D McGee
Keyword(s):  
Extracellular Matrix ◽  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells
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