Effects of the micro-nano surface topography of titanium alloy on the biological responses of osteoblast

2016 ◽  
Vol 105 (3) ◽  
pp. 757-769 ◽  
Author(s):  
Chengcheng Yin ◽  
Yanjing Zhang ◽  
Qing Cai ◽  
Baosheng Li ◽  
Hua Yang ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Surface Topography ◽  
Biological Responses

scholarly journals Machined Surface Topography Investigation in Turning of Titanium Alloy (Ti-6al-4v) Using Steam as A Coolant

2015 ◽  
Vol 12 (2) ◽  
pp. 104-107
Author(s):  
Afaqahmed Jamadar ◽  
Vilas Shinde ◽  
Muhammedumar Jamadar ◽  
Javed Kazi
Keyword(s):  
Titanium Alloy ◽  
Surface Topography ◽  
Machined Surface

Investigation of Abrasive Wear in the Dry Belt Grinding of Titanium Alloy

2011 ◽  
Vol 697-698 ◽  
pp. 121-124 ◽  
Author(s):  
Wen Guo Huo ◽  
Jiu Hua Xu ◽  
Yu Can Fu ◽  
Hou Jun Qi
Keyword(s):  
Titanium Alloy ◽  
Surface Morphology ◽  
Abrasive Wear ◽  
Surface Topography ◽  
Grinding Force ◽  
Milling Machine ◽  
Excellent Performance ◽  
Belt Grinding ◽  
Dry Grinding ◽  
Abrasive Surface

This paper was dedicated to elucidate an investigation of abrasive wear and surface topography of Titanium alloy TA15 on dry grinding with zirconia alumina belt. In the investigation, experiments were performed on milling machine XS5040 equipped with assembled belt grinding device. The wear abrasive, surface morphology of machined belt in different phase were analyzed using 3D viewer microscope. The results show that the wear of belt abrasive is mainly steady attritions wear since zirconia alumina belt was stable on dry grinding. At higher grinding force, the abrasive was found to undergo dislodging prior to being gradually worn. So zirconia alumina belt has excellent performance in the dry grinding titanium alloy.

Study on Grinding Machinability of Titanium Alloy Using SiC Abrasive

2011 ◽  
Vol 487 ◽  
pp. 34-38 ◽  
Author(s):  
Guo Giang Guo ◽  
X.H. Zheng ◽  
Z.Q. Liu ◽  
Qing Long An ◽  
Ming Chen
Keyword(s):  
Titanium Alloy ◽  
High Temperature ◽  
Surface Topography ◽  
Specific Energy ◽  
Ground Surface ◽  
Grinding Force ◽  
Grinding Forces ◽  
Grinding Mechanism ◽  
Dry Conditions ◽  
Metallurgical Structure

Experimental results of Ti-6-2-4-2S, Ti-6-4 and Ti-5-5-5-1-1 are detailed in this paper with conventional surface grinding using SiC abrasive under dry conditions. Measurements of grinding forces, surface topography and metallurgical structure of ground surface were taken to investigate the grinding mechanism of these materials. The results showed grinding force ratios to these materials were between 1.35 to 2.25 at all material remove rates, but the specific energy to Ti-5-5-5-1-1 and Ti-6-2-4-2S were little higher than Ti-6-4. Evaluation of ground surface topography indicated they were visually free of crack and burn. At the same grinding parameters, Ti-5-5-5-1-1 had the maximum depth of heat-affected zone because of its poor high temperature properties.

scholarly journals miR6236, a microRNA suppressed by the anisotropic surface topography, regulates neuronal development and regeneration

2020 ◽  
Author(s):  
Yi-Ju Chen ◽  
Yung-An Huang ◽  
Chris T. Ho ◽  
Jinn-Moon Yang ◽  
Jui-I Chao ◽  
...  
Keyword(s):  
Surface Topography ◽  
Growth And Development ◽  
Neuronal Development ◽  
Therapeutic Potential ◽  
Primary Neurons ◽  
Loss Of Function ◽  
Sequencing Technology ◽  
Anisotropic Surface ◽  
Cellular Changes ◽  
Biological Responses

AbstractIt has been well studied that the surface topography affects the growth and development of neurons. However, the precise mechanism that the surface topography leads to cellular changes remains unknown. In this study, we created an anisotropic surface using nanodiamonds and discovered this surface topography accelerates the development of primary neurons from both the central and peripheral nervous systems. Using RNA sequencing technology, a previously uncharacterized microRNA (miR6236) was found to exhibit significant and the most substantial decrease when neurons are cultured on this nanodiamond surface. Gain- and loss-of-function assays confirm that miR6236 is the predominant molecule responsible for converting the surface topography into biological responses. We further demonstrate that the depletion of miR6236 can enhance neuroregeneration on inhibitory substrate, uncovering its therapeutic potential for promoting central nervous system regeneration.

MILLING FORCE AND SURFACE TOPOGRAPHY OF Ti-6Al-4V TITANIUM ALLOY CLADDED BY THE LASER

2019 ◽  
Vol 26 (05) ◽  
pp. 1850185
Author(s):  
TAO WANG ◽  
YANG LI ◽  
JIAQI LIU ◽  
LINGCHAO QIN ◽  
NING WANG ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Surface Topography ◽  
Laser Cladding ◽  
Milling Process ◽  
Milling Force ◽  
Cladding Layer ◽  
Aero Engine ◽  
Increasing Trend ◽  
Working Performance

After the damaged blade is repaired by laser cladding, the quality of the recontouring by milling determines its working performance in reservice. Ti-6Al-4V, titanium alloy, commonly used as the material of manufacturing aero-engine blades, is selected as the experiment material. Laser cladding technology is used to prepare a cladding layer, and milling experiments are carried out on the cladding layer. The effects of milling process parameters on the milling force, roughness, and surface topography are studied. The results show that when the milling speed ([Formula: see text]) increases to 50[Formula: see text]m/min, the milling force and roughness ([Formula: see text]) reach the maximum and at this moment the surface topography is the worst. Afterwards, with an increase in [Formula: see text], both the milling force and [Formula: see text] decrease in proportion, and the surface topography also becomes better. As the feed per tooth ([Formula: see text]) increases, the milling force and [Formula: see text] also increase. However, the increasing trend gradually slows down. After [Formula: see text] increases to 0.08[Formula: see text]mm/z, the milling force and [Formula: see text] almost no longer increase and the surface topography remains almost unchanged. With an increase in milling width ([Formula: see text]), the milling force and [Formula: see text] increase on the whole. But while [Formula: see text] increases from 0.4[Formula: see text]mm to 0.8[Formula: see text]mm, the milling force and [Formula: see text] increase very slowly. When [Formula: see text] reaches over 0.8[Formula: see text]mm, the milling force and [Formula: see text] increase rapidly again. As [Formula: see text] changes, the surface topography changes according to the milling force and roughness. On this basis, it is found that while machining a laser cladding layer, the milling force directly affects the surface roughness and topography. Therefore, by adjusting [Formula: see text], [Formula: see text], and [Formula: see text], one can obtain the small milling force and good milling surface of the laser cladding TC4 layer.

scholarly journals Modeling and Analysis of Five-Axis Milling Configurations and Titanium Alloy Surface Topography

2016 ◽  
Vol 138 (6) ◽  
Author(s):  
David Prat ◽  
Guillaume Fromentin ◽  
Gérard Poulachon ◽  
Emmanuel Duc
Keyword(s):  
Titanium Alloy ◽  
Surface Topography ◽  
Geometrical Model ◽  
Cutting Conditions ◽  
Modeling And Analysis ◽  
Good Surface ◽  
Good Surface Finish ◽  
Five Axis ◽  
Complex Parts ◽  
Location Point

Five-axis milling with a ball-end cutter is commonly used to generate a good surface finish on complex parts, such as blades or impellers made of titanium alloy. The five-axis milling cutting process is not straight forward; local cutting conditions depend a lot on the geometrical configuration relating to lead and tilt angles. Furthermore, the surface quality is greatly affected by the cutting conditions that define the milling configuration. This study presents a geometrical model of five-axis milling in order to determine the effective cutting conditions, the milling mode, and the cutter location point. Subsequently, an analysis of surface topography is proposed by using the geometrical model, local criteria, and a principle component analysis of experimental data. The results show the effects of local parameters on the surface roughness, in relation to the lead and tilt angles.

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