scholarly journals Winner of the Student Award in the Hospital Intern Category, 10th World Biomaterials Congress, May 17-22, 2016, Montreal QC, Canada: Peptide biomaterials raising adaptive immune responses in wound healing contexts

2016 ◽  
Vol 104 (8) ◽  
pp. 1853-1862 ◽  
Author(s):  
Yalini Vigneswaran ◽  
Huifang Han ◽  
Roberto De Loera ◽  
Yi Wen ◽  
Xing Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
10Th World ◽  
Student Award

scholarly journals The Role of the Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries

2021 ◽  
Vol 22 (24) ◽  
pp. 13552
Author(s):  
Naveena B. Janakiram ◽  
Michael S. Valerio ◽  
Stephen M. Goldman ◽  
Christopher L. Dearth
Keyword(s):  
Wound Healing ◽  
Immune Responses ◽  
Immune Cells ◽  
Military Service ◽  
Adaptive Immune Responses ◽  
Impaired Wound Healing ◽  
Composite Tissue ◽  
Adaptive Immune ◽  
Adaptive Immune Cells ◽  
Tissue Injuries

Composite tissue injuries (CTI) are common among US Military Service members during combat operations, and carry a high potential of morbidity. Furthermore, CTI are often complicated due to an altered wound healing response, resulting in part from a dysregulation of the innate and adaptive immune responses. Unlike normal wound healing, in CTI, disruptions occur in innate immune responses, altering neutrophil functions, macrophage activation and polarization, further impacting the functions of T regulatory cells. Additionally, the biological underpinnings of these unfavorable wound healing conditions are multifactorial, including various processes, such as: ischemia, hypoxia, low nutrient levels, and altered cell metabolic pathways, among others, all of which are thought to trigger anergy in immune cells and destabilize adaptive immune responses. As a result, impaired wound healing is common in CTI. Herein, we review the altered innate and adaptive immune cells and their metabolic status and responses following CTI, and discuss the role a multi-pronged immunomodulatory approach may play in facilitating improved outcomes for afflicted patients.

scholarly journals Phagocytosed Polyhedrin-Cytokine Cocrystal Nanoparticles Provide Sustained Secretion of Bioactive Cytokines from Macrophages

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Astrid Wendler ◽  
Nicholas James ◽  
Michael H. Jones ◽  
Christian Pernstich
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Immune Responses ◽  
Tissue Homeostasis ◽  
Potential Utility ◽  
Active Process ◽  
Phagocytic Cells ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Monocytes And Macrophages

Many cells possess the ability to engulf and incorporate particles by phagocytosis. This active process is characteristic of microorganisms as well as higher order species. In mammals, monocytes, macrophages, and microglia are among the so-called professional phagocytes. In addition, cells such as fibroblast and chondrocytes are classified as nonprofessional phagocytes. Professional phagocytes play important roles in both the innate and adaptive immune responses, wound healing, and tissue homeostasis. Consequently, these cells are increasingly studied as targets and vectors of therapeutic intervention to treat a range of diseases. Professional phagocytes are notoriously difficult to transfect limiting their study and manipulation. Consequently, efforts have shifted towards the development of nanoparticles to deliver a cargo to phagocytic cells via phagocytosis. However, this approach carries significant technical challenges, particularly for protein cargos. We have focused on the development of nanoscale cocrystalline protein depots, known as PODS®, that contain protein cargos, including cytokines. Here, we show that PODS are readily phagocytosed by nonprofessional as well as professional phagocytic cells and have attributes, such as highly sustained release of cargo, that suggest potential utility for the study and exploitation of phagocytic cells for drug delivery. Monocytes and macrophages that ingest PODS retain normal characteristics including a robust chemotactic response. Moreover, the PODS-cytokine cargo is secreted by the loaded cell at a level sufficient to modulate the behavior of surrounding nonphagocytic cells. The results presented here demonstrate the potential of PODS nanoparticles as a novel molecular tool for the study and manipulation of phagocytic cells and for the development of Trojan horse immunotherapy strategies to treat cancer and other diseases.

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