scholarly journals Cell number and chondrogenesis in human mesenchymal stem cell aggregates is affected by the sulfation level of heparin used as a cell coating

2016 ◽  
Vol 104 (7) ◽  
pp. 1817-1829 ◽  
Author(s):  
Jennifer Lei ◽  
Elda Trevino ◽  
Johnna Temenoff
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Cell Number ◽  
Cell Aggregates ◽  
Cell Coating ◽  
A Cell

scholarly journals Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Melika Sarem ◽  
Oliver Otto ◽  
Simon Tanaka ◽  
V. Prasad Shastri
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Number ◽  
Cell Stiffness ◽  
Cell Aggregates

Metabolic Reconfiguration Supports Reacquisition of Primitive Phenotype in Human Mesenchymal Stem Cell Aggregates

Stem Cells ◽  
2016 ◽  
Vol 35 (2) ◽  
pp. 398-410 ◽  
Author(s):  
Yijun Liu ◽  
Nathalie Muñoz ◽  
Ang-Chen Tsai ◽  
Timothy M. Logan ◽  
Teng Ma
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Cell Aggregates

In vivo study of the angiogenesis potential of bone marrow-derived mesenchymal stem cell aggregates in their niche like environment

2021 ◽  
pp. 039139882110255
Author(s):  
Sara Anajafi ◽  
Azam Ranjbar ◽  
Monireh Torabi-Rahvar ◽  
Naser Ahmadbeigi
Keyword(s):  
Tissue Engineering ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cultured Cells ◽  
Morphological Evidence ◽  
Cell Aggregates ◽  
Plla Scaffold ◽  
Significant Difference

Background: Sufficient blood vessel formation in bioengineered tissues is essential in order to keep the viability of the organs. Impaired development of blood vasculatures results in failure of the implanted tissue. The cellular source which is seeded in the scaffold is one of the crucial factors involved in tissue engineering methods. Materials and methods: Considering the notable competence of Bone Marrow derived Mesenchymal Stem Cell aggregates for tissue engineering purposes, in this study BM-aggregates and expanded BM-MSCs were applied without any inductive agent or co-cultured cells, in order to investigate their own angiogenesis potency in vivo. BM-aggregates and BM-MSC were seeded in Poly-L Lactic acid (PLLA) scaffold and implanted in the peritoneal cavity of mice. Result: Immunohistochemistry results indicated that there was a significant difference ( p < 0.050) in CD31+ cells between PLLA scaffolds contained cultured BM-MSC; PLLA scaffolds contained BM-aggregates and empty PLLA. According to morphological evidence, obvious connections with recipient vasculature and acceptable integration with surroundings were established in MSC and aggregate-seeded scaffolds. Conclusion: Our findings revealed cultured BM-MSC and BM-aggregates, capacity in order to develop numerous connections between PLLA scaffold and recipient’s vasculature which is crucial to the survival of tissues, and considerable tendency to develop constructs containing CD31+ endothelial cells which can contribute in vessel’s tube formation.

scholarly journals A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172925 ◽  
Author(s):  
Dale B. Bosco ◽  
Mark D. Roycik ◽  
Yonghao Jin ◽  
Martin A. Schwartz ◽  
Ty J. Lively ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Matrix Metalloproteinase ◽  
Human Mesenchymal Stem Cell ◽  
Matrix Metalloproteinase Inhibitor ◽  
Metalloproteinase Inhibitor ◽  
Synthetic Matrix
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