Effects of flow configuration on bone tissue engineering using human mesenchymal stem cells in 3D chitosan composite scaffolds

2014 ◽  
Vol 103 (8) ◽  
pp. 2509-2520 ◽  
Author(s):  
Katelyn L. Sellgren ◽  
Teng Ma
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cells ◽  
Composite Scaffolds ◽  
Flow Configuration ◽  
Chitosan Composite

The Response of Human Mesenchymal Stem Cells to Osteogenic Signals and its Impact on Bone Tissue Engineering

2007 ◽  
Vol 2 (3) ◽  
pp. 209-220 ◽  
Author(s):  
Ramakrishnaiah Siddappa ◽  
Hugo Fernandes ◽  
Jun Liu ◽  
Clemens Blitterswijk ◽  
Jan de Boer
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cells

Bone Tissue Engineering Using Human Mesenchymal Stem Cells: Effects of Scaffold Material and Medium Flow

2004 ◽  
Vol 32 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Lorenz Meinel ◽  
Vassilis Karageorgiou ◽  
Robert Fajardo ◽  
Brian Snyder ◽  
Vivek Shinde-Patil ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cells ◽  
Scaffold Material ◽  
Medium Flow

scholarly journals Recent Advances in Mechanically Loaded Human Mesenchymal Stem Cells for Bone Tissue Engineering

2020 ◽  
Vol 21 (16) ◽  
pp. 5816
Author(s):  
Kar Wey Yong ◽  
Jane Ru Choi ◽  
Jean Yu Choi ◽  
Alistair C. Cowie
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Graft ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Loading ◽  
Bone Repair ◽  
Human Mesenchymal Stem Cells ◽  
Bone Defects

Large bone defects are a major health concern worldwide. The conventional bone repair techniques (e.g., bone-grafting and Masquelet techniques) have numerous drawbacks, which negatively impact their therapeutic outcomes. Therefore, there is a demand to develop an alternative bone repair approach that can address the existing drawbacks. Bone tissue engineering involving the utilization of human mesenchymal stem cells (hMSCs) has recently emerged as a key strategy for the regeneration of damaged bone tissues. However, the use of tissue-engineered bone graft for the clinical treatment of bone defects remains challenging. While the role of mechanical loading in creating a bone graft has been well explored, the effects of mechanical loading factors (e.g., loading types and regime) on clinical outcomes are poorly understood. This review summarizes the effects of mechanical loading on hMSCs for bone tissue engineering applications. First, we discuss the key assays for assessing the quality of tissue-engineered bone grafts, including specific staining, as well as gene and protein expression of osteogenic markers. Recent studies of the impact of mechanical loading on hMSCs, including compression, perfusion, vibration and stretching, along with the potential mechanotransduction signalling pathways, are subsequently reviewed. Lastly, we discuss the challenges and prospects of bone tissue engineering applications.

An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering

2018 ◽  
Vol 27 (23) ◽  
pp. 1634-1645 ◽  
Author(s):  
Yunpeng Zhang ◽  
Yixiao Xing ◽  
Linglu Jia ◽  
Yawen Ji ◽  
Bin Zhao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Comparative Study ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cells

3D environment on human mesenchymal stem cells differentiation for bone tissue engineering

2009 ◽  
Vol 21 (3) ◽  
pp. 981-987 ◽  
Author(s):  
T. Cordonnier ◽  
P. Layrolle ◽  
Julien Gaillard ◽  
Alain Langonné ◽  
L. Sensebé ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cells ◽  
3D Environment
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