Osteoblasts behavior on chemically treated commercially pure titanium surfaces

2013 ◽  
Vol 102 (6) ◽  
pp. 1816-1822 ◽  
Author(s):  
D. P. Oliveira ◽  
A. Palmieri ◽  
F. Carinci ◽  
C. Bolfarini
2014 ◽  
Vol 28 (12) ◽  
pp. 1207-1218 ◽  
Author(s):  
Miguel A. Fernández-Rodríguez ◽  
Alda Y. Sánchez-Treviño ◽  
Elvira De Luna-Bertos ◽  
Javier Ramos-Torrecillas ◽  
Olga García-Martínez ◽  
...  

Author(s):  
Gry Hulsart-Billström ◽  
Oscar Janson ◽  
Håkan Engqvist ◽  
Ken Welch ◽  
Jaan Hong

Abstract The release of growth factors from platelets, mediated by the coagulation and the complement system, plays an important role in the bone formation around implants. This study aimed at exploring the thromboinflammatory response of H2O2-alkali soaked commercially pure titanium grade 2 discs exposed to whole human blood, as a way to assess the bioactivity of the discs. Commercially pure titanium grade 2 discs were modified by soaking in H2O2, NaOH and Ca(OH)2. The platelet aggregation, coagulation activation and complement activation was assessed by exposing the discs to fresh whole blood from human donors. The platelet aggregation was examined by a cell counter and the coagulation and complement activation were assessed by ELISA-measurements of the concentration of thrombin-antithrombin complex, C3a and terminal complement complex. The modified surface showed a statistically significant increased platelet aggregation, coagulation activation and complement activation compared to unexposed blood. The surface also showed a statistically significant increase of coagulation activation compared to PVC. The results of this study showed that the H2O2-alkali soaked surfaces induced a thromboinflammatory response that indicates that the surfaces are bioactive.


2019 ◽  
Vol 7 (4) ◽  
pp. 109 ◽  
Author(s):  
Tetsuhiro Tsujino ◽  
Akira Takahashi ◽  
Taisuke Watanabe ◽  
Kazushige Isobe ◽  
Yutaka Kitamura ◽  
...  

Recent progress in the industrial development of dental implants has improved their surface bio-affinity, while clinical implantologists attempt to improve it through coating with various compounds, including platelet-rich plasma (PRP) in clinical settings. However, it is poorly understood how PRP acts on titanium surfaces. To validate this surface modification method and demonstrate how platelet-derived soluble biomolecules released from the activated adherent platelets act on plain, commercially pure-titanium (cp-Ti) plates, we evaluated the distribution of biomolecules by immunofluorescence. PPARγ, PDGF-B, and TGFβ1 were similarly released at immunofluorescence levels from activated adherent platelets, retained in the surrounding extra-platelet spaces for a while, and did not immediately diffuse away to distant spaces. Exogenously added CaCl2 augmented release and retention of those biomolecules along with activation and aggregation. Taken together with our previous data regarding platelet adhesion, these findings suggest that especially when treated with CaCl2, platelets immediately adhere on cp-Ti plates to release their stored biomolecules in the absence of plasma proteins and that these biomolecules do not diffuse away, but stay longer in extra-platelet spaces around the platelets by newly formed, immature fibrin fiber fragments. Consequently, these retained biomolecules are anticipated to cooperatively stabilize implants by stimulating alveolar bone regeneration and integration.


2016 ◽  
Vol 11 (3) ◽  
pp. 031008 ◽  
Author(s):  
Isabella da Silva Vieira Marques ◽  
Maria Fernanda Alfaro ◽  
Miki Taketomi Saito ◽  
Nilson Cristino da Cruz ◽  
Christos Takoudis ◽  
...  

RSC Advances ◽  
2016 ◽  
Vol 6 (82) ◽  
pp. 78795-78802 ◽  
Author(s):  
Izabelle M. Gindri ◽  
Danyal A. Siddiqui ◽  
Clarissa P. Frizzo ◽  
Marcos A. P. Martins ◽  
Danieli C. Rodrigues

In this work, dicationic imidazolium-based ionic liquids (ILs) with amino acid anionic moieties were employed as coatings for commercially pure titanium (Ti) surfaces.


2013 ◽  
Vol 92 ◽  
pp. 42-44 ◽  
Author(s):  
A. Rodríguez-Hernández ◽  
E. Espinar ◽  
J.M. Llamas ◽  
J.M. Barrera ◽  
F.J. Gil

2016 ◽  
Vol 389 ◽  
pp. 270-277 ◽  
Author(s):  
Katarzyna Rudzka ◽  
Alda Y. Sanchez Treviño ◽  
Miguel A. Rodríguez-Valverde ◽  
Miguel A. Cabrerizo-Vílchez

2005 ◽  
Vol 288-289 ◽  
pp. 343-346 ◽  
Author(s):  
Yuehuei H. An ◽  
Melissa Farino ◽  
Qian K. Kang ◽  
Marina V. Demcheva ◽  
John Vournakis

It is known that glucosamine/chitosan derivatives have the ability of inhibiting bacterial adhesion to tooth and biomaterial surfaces. The hypotheses of this article included 1) the inhibition effects of different (chemically) glucosamine products are different and 2) more water-soluble glucosamine preparation(s) may have a superior inhibition effect. The basic testing systems are in vitro static adhesion models and the amount of the adhesion is evaluated by direct counting using epifluorecense microscopy. The test material is a smooth surfaced commercially pure titanium (cp-Ti). The bacterium tested is Staphylococcus aureus. The results showed that compared to the control samples (without glucosamine or chitosan coating) the sulfated p-GlcNAc and Sigma glucosamine HCl significantly inhibited S. aureus adhesion to titanium surfaces (94% and 78% respectively)


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