Biomaterials and biotechnology: From the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering

2013 ◽  
Vol 101A (9) ◽  
pp. 2449-2455 ◽  
Author(s):  
Robert Langer
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Angiogenesis Inhibitors ◽  
Delivery Systems

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

2021 ◽  
Vol 11 (23) ◽  
pp. 11369
Author(s):  
Ashni Arun ◽  
Pratyusha Malrautu ◽  
Anindita Laha ◽  
Hongrong Luo ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Solubility ◽  
Stimuli Responsive ◽  
Preparation Methods ◽  
Nanoparticle Preparation ◽  
Responsive Behavior ◽  
Reduced Toxicity

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

Dual-pH/Magnetic-Field-Controlled Drug Delivery Systems Based on Fe3 O4 @SiO2 -Incorporated Salecan Graft Copolymer Composite Hydrogels

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1600-1609 ◽  
Author(s):  
Xinyu Hu ◽  
Yongmei Wang ◽  
Liangliang Zhang ◽  
Man Xu ◽  
Jianfa Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Graft Copolymer ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Composite Hydrogels

Understanding the Diffusion of Dextrans in ‘Click' PNIPAAm Hydrogels

2014 ◽  
Vol 67 (1) ◽  
pp. 85
Author(s):  
Huey Wen Ooi ◽  
Hui Peng ◽  
Kevin S. Jack ◽  
Andrew K. Whittaker
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Mesh Size ◽  
Controlled Drug Delivery ◽  
Molecular Size ◽  
Delivery Systems ◽  
Restricted Diffusion ◽  
Probe Molecules ◽  
Network Studies

Arguably the most important property of a hydrogel is the ability to allow the diffusion of solutes through the crosslinked network. Studies of the diffusion in hydrogels are important for providing information on the rate and extent of the passage of the solute and on the details of the microstructure of the hydrogel. Such knowledge is directly relevant for applications such as controlled drug delivery systems. The structure of novel poly(N-isopropylacrylamide) (PNIPAAm) hydrogels can be revealed by the restricted diffusion of appropriate probe molecules. Dextran molecules, labelled with fluorescent moieties, were incorporated into well-defined PNIPAAm hydrogels to investigate the effects of hydrogel mesh size and dextran molecular size on the diffusivities of solute molecules.

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