Toxicity andin vivobiological effect of the nanoparticular self-supported hydrogel of a thermosensitive copolymer for non-invasive drug delivery

2013 ◽  
Vol 102 (1) ◽  
pp. 17-29 ◽  
Author(s):  
Weiwei Wang ◽  
Liandong Deng ◽  
Pingsheng Huang ◽  
Shuxin Xu ◽  
Xu Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Non Invasive ◽  
Thermosensitive Copolymer

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

Bioinspired Particle Engineering for Non-invasive Inhaled Drug Delivery to the Lungs

2021 ◽  
pp. 112324
Author(s):  
Snehal K. Shukla ◽  
Apoorva Sarode ◽  
Dipti D. Kanabar ◽  
Aaron Muth ◽  
Nitesh K. Kunda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Engineering ◽  
Non Invasive ◽  
Inhaled Drug Delivery

Iontophoresis: A non-invasive ocular drug delivery

2006 ◽  
Vol 110 (3) ◽  
pp. 479-489 ◽  
Author(s):  
Esther Eljarrat-Binstock ◽  
Abraham J. Domb
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Non Invasive

scholarly journals Multiplexed Non-invasive in vivo Imaging to Assess Metabolism and Receptor Engagement in Tumor Xenografts

2019 ◽  
Author(s):  
Alena Rudkouskaya ◽  
Nattawut Sinsuebphon ◽  
Marien Ochoa ◽  
Joe E. Mazurkiewicz ◽  
Xavier Intes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Metabolic Response ◽  
Imaging Modalities ◽  
Wide Field ◽  
Receptor Ligand ◽  
Non Invasive ◽  
Intracellular Drug Delivery

AbstractFollowing an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. To date, non-invasive quantitative imaging modalities that can comprehensively assess simultaneous cellular drug delivery efficacy and therapeutic response are lacking. In this regard, Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imaging offers a unique method to robustly quantify receptor-ligand engagement in vivo and subsequent intracellular internalization, which is critical to assess the delivery efficacy of targeted therapeutics. However, implementation of multiplexing optical imaging with FRET in vivo is challenging to achieve due to spectral crowding and cross-contamination. Herein, we report on a strategy that relies on a dark quencher that enables simultaneous assessment of receptor-ligand engagement and tumor metabolism in intact live mice. First, we establish that IRDye QC-1 (QC-1) is an effective NIR dark acceptor for the FRET-induced quenching of donor Alexa Fluor 700 (AF700) using in vitro NIR FLI microscopy and in vivo wide-field MFLI imaging. Second, we report on simultaneous in vivo imaging of the metabolic probe IRDye 800CW 2-deoxyglucose (2-DG) and MFLI-FRET imaging of NIR-labeled transferrin FRET pair (Tf-AF700/Tf-QC-1) uptake in tumors. Such multiplexed imaging revealed an inverse relationship between 2-DG uptake and Tf intracellular delivery, suggesting that 2-DG signal may predict the efficacy of intracellular targeted delivery. Overall, our methodology enables for the first time simultaneous non-invasive monitoring of intracellular drug delivery and metabolic response in preclinical studies.

Evolutionary Soft Robotics

Impact ◽  
2019 ◽  
Vol 2019 (10) ◽  
pp. 9-11
Author(s):  
Jun Ogawa
Keyword(s):  
Artificial Intelligence ◽  
Drug Delivery ◽  
Soft Matter ◽  
Associate Professor ◽  
Assistive Devices ◽  
Artificial Organs ◽  
Soft Robotics ◽  
Elastic Materials ◽  
Non Invasive ◽  
Living Organisms

Soft robotics is a subfield of robots that deals with constructing robots from soft, elastic materials similar to those found in living organisms. These robots offer a particular set of advantages compared with conventional rigid robots. For example, in medicine they can be used in drug delivery and non-invasive surgical procedures, and be employed as assistive devices, prostheses or artificial organs. The field takes great inspiration from the way living organisms move and adapt to their surroundings, and the flexibility and adaptability of soft robots make them invaluable tools. Dr Jun Ogawa is an Associate Professor in the Institute of Organic Materials at Yamagata University, Japan. His key research interests are soft matter robotics and embodied artificial intelligence (AI).

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