Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model

2012 ◽  
Vol 100A (11) ◽  
pp. 2881-2889 ◽  
Author(s):  
Peter P. Mueller ◽  
Sylvia Arnold ◽  
Muhammad Badar ◽  
Dirk Bormann ◽  
Friedrich-Wilhelm Bach ◽  
...  
Keyword(s):  
Animal Model ◽  
Medical Implant ◽  
Implant Material ◽  
Molecular Evaluation

Surface Roughness Characterization of Medical Implant Material SS316L Stainless Steel after Cut with Water Jet Cutting Process

2020 ◽  
Vol 867 ◽  
pp. 182-187
Author(s):  
Teguh Dwi Widodo ◽  
Rudianto Raharjo ◽  
Muhammad Zaimi
Keyword(s):  
Surface Roughness ◽  
Traverse Speed ◽  
Water Jet ◽  
Cutting Process ◽  
Abrasive Water Jet ◽  
Medical Implant ◽  
Implant Material ◽  
Water Jet Cutting ◽  
Abrasive Water Jet Cutting ◽  
Study Results

In this paper, the effect of abrasive water jet cutting process on the surface character of medical implant SS316L was investigated. This research focuses on the effect of traverse speed during abrasive water jet cutting on the surface roughness and topography of medical implant material SS316L. In some study, it has been noted that the roughness of implant material correlates with the healing process of a sufferer in medical application. Furthermore, transverse speed has an important role in the manufacturing process that correlates directly with the ability of technic to produce a product at a definite time. Garnet was used as an abrasive material in this water jet cutting process. The process was taking place in room temperature with 3000Psi of water pressure. In this study, the surface roughness was examined at all point of depth of the cut surface in all of the transverse speed using Mitutoyo SJ 210, while the surface topography observed by Olympus BX53M optical microscope. The study results reveal that traverse speed has a significant effect on the surface roughness at the surface, middle, and bottom of the cut point. The Surface roughness increase as transverse speed.

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

Electron Microscopic Detection and Characterization of Nonhuman Primate Enteric Viruses

1982 ◽  
Vol 40 ◽  
pp. 306-307
Author(s):  
G. C. Smith ◽  
R. L. Heberling ◽  
S. S. Kalter
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Nonhuman Primate ◽  
Clinical Condition ◽  
Intestinal Tract ◽  
Enteric Viruses ◽  
Electron Microscopic ◽  
Microscopic Detection

A number of viral agents are recognized as and suspected of causing the clinical condition “gastroenteritis.” In our attempts to establish an animal model for studies of this entity, we have been examining the nonhuman primate to ascertain what viruses may be found in the intestinal tract of “normal” animals as well as animals with diarrhea. Several virus types including coronavirus, adenovirus, herpesvirus, and picornavirus (Table I) were detected in our colony; however, rotavirus, astrovirus, and calicivirus have not yet been observed. Fecal specimens were prepared for electron microscopy by procedures reported previously.

Neurofilaments and Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 740-743
Author(s):  
J. Metuzals
Keyword(s):  
Animal Model ◽  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Squid Giant Axon ◽  
In Vitro Experiments ◽  
Thin Sections ◽  
Structural Relationships

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.

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