Improving cellular function and immune protection via layer-by-layer nanocoating of pancreatic islet β-cell spheroids cocultured with mesenchymal stem cells

2012 ◽  
Vol 100A (6) ◽  
pp. 1628-1636 ◽  
Author(s):  
Tasneem Bhaiji ◽  
Zheng-Liang Zhi ◽  
John C. Pickup
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pancreatic Islet ◽  
Cellular Function ◽  
Layer By Layer ◽  
Immune Protection ◽  
Β Cell ◽  
Cell Spheroids

scholarly journals A microRNA delivery carrier for hepatic carcinoma therapy using layer-by-layer self-assembled mesenchymal stem cells

2020 ◽  
Vol 9 (9) ◽  
pp. 5380-5389
Author(s):  
Chunmin Li ◽  
Xin Li ◽  
Fengsheng Li ◽  
Dawei Wang ◽  
Jin Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Layer By Layer ◽  
Hepatic Carcinoma ◽  
Self Assembled ◽  
Microrna Delivery

Microphysiological Analysis Platform of Pancreatic Islet β-Cell Spheroids

2017 ◽  
Vol 7 (2) ◽  
pp. 1701111 ◽  
Author(s):  
Sang Hun Lee ◽  
SoonGweon Hong ◽  
Jihwan Song ◽  
Byungrae Cho ◽  
Esther J. Han ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Β Cell ◽  
Cell Spheroids ◽  
Analysis Platform

Retinoic Acid-induced Differentiation of Rat Mesenchymal Stem Cells into β-Cell Lineage

2015 ◽  
Vol 29 (3) ◽  
pp. 118 ◽  
Author(s):  
Jae Hyung Kim ◽  
Kyung Sik Kim ◽  
Sang Woo Lee ◽  
Hyun Woo Kim ◽  
Dong Jin Joo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Retinoic Acid ◽  
Cell Lineage ◽  
Β Cell ◽  
Induced Differentiation

Human omentum fat-derived mesenchymal stem cells transdifferentiates into pancreatic islet-like cluster

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
M Dhanasekaran ◽  
S Indumathi ◽  
R Harikrishnan ◽  
Rashmi Mishra ◽  
RP Lissa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pancreatic Islet

Bone marrow-derived mesenchymal stem cells co-cultured with pancreatic islets display β cell plasticity

2010 ◽  
Vol 5 (6) ◽  
pp. 491-500 ◽  
Author(s):  
Erdal Karaoz ◽  
Selda Ayhan ◽  
Alparslan Okçu ◽  
Ayça Aksoy ◽  
Gülay Bayazıt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Pancreatic Islets ◽  
Cell Plasticity ◽  
Β Cell

scholarly journals Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro

2013 ◽  
Vol 18 (1) ◽  
Author(s):  
Dhanasekaran Marappagounder ◽  
Indumathi Somasundaram ◽  
Sudarsanam Dorairaj ◽  
Rajkumar Sankaran
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Pancreatic Islet ◽  
Subcutaneous Adipose Tissue ◽  
Lineage Differentiation ◽  
Wide Range ◽  
Subcutaneous Adipose

AbstractAlthough stem cells are present in various adult tissues and body fluids, bone marrow has been the most popular source of stem cells for treatment of a wide range of diseases. Recent results for stem cells from adipose tissue have put it in a position to compete for being the leading therapeutic source. The major advantage of these stem cells over their counterparts is their amazing proliferative and differentiation potency. However, their pancreatic lineage transdifferentiation competence was not compared to that for bone marrow-derived stem cells. This study aims to identify an efficient source for transdifferentiation into pancreatic islet-like clusters, which would increase potential application in curative diabetic therapy. The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet-like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin, PDX1, Isl 1, Ngn 3, Pax 4 and Insulin. The pancreatic lineage differentiation was further corroborated by positive results in the glucose challenge assay. However, the results indicate that bone marrow-derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet-like clusters. In conclusion, bone marrow-derived MSC might serve as a better alternative in the treatment of diabetes mellitus than those from adipose tissue.

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