Preparation of a biomimetic nanocomposite scaffold for bone tissue engineering via mineralization of gelatin hydrogel and study of mineral transformation in simulated body fluid

2012 ◽  
Vol 100A (5) ◽  
pp. 1347-1355 ◽  
Author(s):  
Mahmoud Azami ◽  
Mir Javad Moosavifar ◽  
Nafiseh Baheiraei ◽  
Fathollah Moztarzadeh ◽  
Jafar Ai
Keyword(s):  
Tissue Engineering ◽  
Simulated Body Fluid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Body Fluid ◽  
Mineral Transformation ◽  
Gelatin Hydrogel ◽  
Nanocomposite Scaffold

Evaluation of the in vitro biodegradation and biological behavior of poly(lactic-co-glycolic acid)/nano-fluorhydroxyapatite composite microsphere-sintered scaffold for bone tissue engineering

2017 ◽  
Vol 33 (2) ◽  
pp. 146-159 ◽  
Author(s):  
Mohammadreza Tahriri ◽  
Fathollah Moztarzadeh ◽  
Arash Tahriri ◽  
Hossein Eslami ◽  
Kimia Khoshroo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Weight Loss ◽  
Simulated Body Fluid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Body Fluid ◽  
Bone Repair ◽  
Glycolic Acid ◽  
Composite Scaffold

The objective of this research was to study the degradation and biological characteristics of the three-dimensional porous composite scaffold made of poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite microsphere using sintering method for potential bone tissue engineering. Our previous experimental results demonstrated that poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite composite scaffold with a ratio of 4:1 sintered at 90ºC for 2 h has the greatest mechanical properties and a proper pore structure for bone repair applications. The weight loss percentage of both poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite and poly(lactic- co-glycolic acid) scaffolds demonstrated a monotonic trend with increasing degradation time, that is, the incorporation of nano-fluorhydroxyapatite into polymeric scaffold could lead to weight loss in comparison with that of pure poly(lactic- co-glycolic acid). The pH change for composite scaffolds showed that there was a slight decrease until 2 weeks after immersion in simulated body fluid, followed by a significant increase in the pH of simulated body fluid without a scaffold at the end of immersion time. The mechanical properties of composite scaffold were higher than that of poly(lactic- co-glycolic acid) scaffold at total time of incubation in simulated body fluid; however, it should be noted that the incorporation of nano-fluorhydroxyapatite into composite scaffold leads to decline in the relatively significant mechanical strength and modulus during hydrolytic degradation. In addition, MTT assay and alkaline phosphatase activity results defined that a general trend of increasing cell viability was seen for poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite scaffold sintered by time when compared to control group. Eventually, experimental results exhibited poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite microsphere-sintered scaffold is a promising scaffold for bone repair.

Mineralization of phosphorylated cellulose/ sodium alginate sponges as biomaterials for bone tissue engineering

2021 ◽  
Author(s):  
li Zha ◽  
Yahui Zheng ◽  
Jianfei Che ◽  
Yinghong Xiao
Keyword(s):  
Tissue Engineering ◽  
Simulated Body Fluid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sodium Alginate ◽  
Body Fluid ◽  
Hydroxyl Groups ◽  
Cellulose Sponge

In recent years cellulose sponge is attractive for bone tissue materials in tissue engineering, however cellulose with hydroxyl groups shows weak apatite nucleation ability in simulated body fluid (SBF). In...

Metformin-loaded nanospheres laden photocrosslinkable gelatin hydrogel for bone tissue engineering

2020 ◽  
pp. 104293
Author(s):  
Liu Qu ◽  
Nileshkumar Dubey ◽  
Juliana S. Ribeiro ◽  
Ester A.F. Bordini ◽  
Jessica A. Ferreira ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Gelatin Hydrogel

scholarly journals 3D conductive nanocomposite scaffold for bone tissue engineering

2013 ◽  
pp. 167 ◽  
Author(s):  
Tayebi ◽  
Aref Shahini ◽  
Mostafa Yazdimamaghani ◽  
Kenneth Jimmy Walker ◽  
Margaret Eastman ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nanocomposite Scaffold

Development of a nanocomposite scaffold of gelatin–alginate–graphene oxide for bone tissue engineering

2019 ◽  
Vol 133 ◽  
pp. 592-602 ◽  
Author(s):  
Shiv Dutt Purohit ◽  
Rakesh Bhaskar ◽  
Hemant Singh ◽  
Indu Yadav ◽  
Mukesh Kumar Gupta ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nanocomposite Scaffold
Sign in / Sign up

Export Citation Format

Share Document