Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties

2011 ◽  
Vol 99A (4) ◽  
pp. 554-563 ◽  
Author(s):  
Zonggang Chen ◽  
Huanye Liu ◽  
Xi Liu ◽  
Fu-Zhai Cui
Keyword(s):  
Calcium Sulfate ◽  
Bone Repair ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
Mineralized Collagen

Injectable mineralized collagen-based bone repair materials

2013 ◽  
Vol 172 (1) ◽  
pp. e148-e149 ◽  
Author(s):  
Zonggang Chen ◽  
Huanye Liu ◽  
Xi Liu ◽  
Zhongwu Guo ◽  
Fu-Zhai Cui
Keyword(s):  
Bone Repair ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
Mineralized Collagen

Multi-stage controllable degradation of strontium-doped calcium sulfate hemihydrate-Tricalcium phosphate microsphere composite as a substitute for osteoporotic bone defect repairing: Degradation behavior and bone response

2021 ◽  
Author(s):  
Qiuju Miao ◽  
Nan Jiang ◽  
Qinmeng Yang ◽  
Ismail mohamed Hussein ◽  
Zhen Luo ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Calcium Sulfate ◽  
Bone Repair ◽  
Degradation Rate ◽  
Bone Defects ◽  
Osteoporotic Bone ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
In Vivo Degradation

Abstract Various requirements for the repair of complex bone defects have motivated to development of scaffolds with adjustable degradation rates and biological functions. Tricalcium phosphate and calcium sulfate are the most commonly used bone repair materials in the clinic, how to better combine tricalcium phosphate and calcium sulfate and play their greatest advantages in the repair of osteoporotic bone defect is the focus of our research. In this study, a series of scaffolds with multistage-controlled degradation properties composed of strontium-doped calcium sulfate (SrCSH) and strontium-doped tricalcium phosphate microspheres (Sr-TCP) scaffolds were prepared, and their osteogenic activity, in vivo degradation and bone regeneration ability in tibia of osteoporotic rats were evaluated. In vitro studies revealed that different components of SrCSH/Sr-TCP scaffolds significantly promoted the proliferation and differentiation of MC3T3-E1 cells, which showed a good osteogenic induction activity. In vivo degradation results showed that the degradation time of composite scaffolds could be controlled in a large range (6-12 months) by controlling the porosity and phase composition of Sr-TCP microspheres. The results of osteoporotic femoral defect repair showed that when the degradation rate of scaffold matched with the growth rate of new bone, the parameters such as BMD, BV/TV, Tb.Th, angiogenesis marker CD31 and new bone formation marker OCN expression were higher, which promoted the rapid repair of osteoporotic bone defects. On the contrary, the slow degradation rate of scaffolds hindered the growth of new bone to a certain extent. This study elucidates the importance of the degradation rate of scaffolds for the repair of osteoporotic bone defects, and the design considerations can be extended to other bone repair materials, which is expected to provide new ideas for the development of tissue engineering materials in the future.

In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg–Ca alloy composites for osteogenesis

2022 ◽  
pp. 088532822110492
Author(s):  
Zhenbao Zhang ◽  
Xirao Sun ◽  
Jingxin Yang ◽  
Chengyue Wang
Keyword(s):  
Corrosion Resistance ◽  
Bone Repair ◽  
Umbilical Vein ◽  
Matrix Mineralization ◽  
Repair Materials ◽  
Micro Arc Oxidation ◽  
Umbilical Vein Endothelial Cells ◽  
Endothelial Growth Factor ◽  
Mineralized Collagen

Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials. However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications. In this study, micro-arc oxidation coating was prepared on the surface of the Mg–Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg–Ca matrix to construct the CS-nHAC/Mg–Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively). The corrosion resistance, osteogenic activity, and angiogenic ability were extensively investigated. The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs). In addition, the CS-nHAC/Mg–Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs. Meanwhile, the 2CS-1nHAC/Mg–Ca composite exhibited the optimum function characteristics compared with other samples. Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg–Ca composites are expected to be a promising orthopedic implant.

Peptide‐modified bone repair materials: Factors influencing osteogenic activity

2019 ◽  
Vol 107 (7) ◽  
pp. 1491-1512 ◽  
Author(s):  
Jie Liao ◽  
Shuai Wu ◽  
Kun Li ◽  
Yubo Fan ◽  
Nicholas Dunne ◽  
...  
Keyword(s):  
Bone Repair ◽  
Osteogenic Activity ◽  
Factors Influencing ◽  
Repair Materials ◽  
Bone Repair Materials

Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials

2017 ◽  
Vol 5 (12) ◽  
pp. 2245-2253 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Zheng-liang Xu ◽  
Qin-Fei Ke ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Self Assembly ◽  
Bone Repair ◽  
Repair Materials ◽  
Double Hydroxide ◽  
First Time ◽  
Bone Repair Materials

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.

Study on osteointegrative properties of a functional gradient tumor bone repair materials in ulna bone defect model of rabbits

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S432
Author(s):  
Shihui Chen ◽  
Tao Tang ◽  
Zhong Liu ◽  
Poying Lau ◽  
Xinhui Xie ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Repair ◽  
Defect Model ◽  
Functional Gradient ◽  
Repair Materials ◽  
Bone Repair Materials
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