An in vitro study of plasticized poly(lactic-co-glycolic acid) films as possible guided tissue regeneration membranes: Material properties and drug release kinetics

2010 ◽  
Vol 95A (3) ◽  
pp. 857-869 ◽  
Author(s):  
Gethin Rh. Owen ◽  
John K. Jackson ◽  
Babak Chehroudi ◽  
Donald M. Brunette ◽  
Helen M. Burt
Keyword(s):  
Drug Release ◽  
Tissue Regeneration ◽  
Material Properties ◽  
Glycolic Acid ◽  
Release Kinetics ◽  
In Vitro Study ◽  
Guided Tissue Regeneration ◽  
Vitro Study ◽  
Drug Release Kinetics

Antimicrobial effect of nanostructured membranes for guided tissue regeneration: an in vitro study

2020 ◽  
Vol 36 (12) ◽  
pp. 1566-1577 ◽  
Author(s):  
J. Bueno ◽  
MC. Sánchez ◽  
M. Toledano-Osorio ◽  
E. Figuero ◽  
M. Toledano ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
In Vitro Study ◽  
Antimicrobial Effect ◽  
Guided Tissue Regeneration ◽  
Vitro Study ◽  
Nanostructured Membranes

scholarly journals Development of a membrane for guided tissue regeneration: An in vitro study

2020 ◽  
Vol 31 (5) ◽  
pp. 763
Author(s):  
VanaraF Passos ◽  
RamonC Fernandes ◽  
MárioIgor Damasceno ◽  
Gabriel Pimentel ◽  
JulianoS Mendonça ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
In Vitro Study ◽  
Guided Tissue Regeneration ◽  
Vitro Study

Cytotoxicity of different concentrations of glycolic acid and its effects on root dentin microhardness – An in vitro study

2021 ◽  
Author(s):  
Matheus A. Souza ◽  
Karolina F. Bischoff ◽  
Bárbara D. C. Rigo ◽  
Larissa Piuco ◽  
Ana V. L. Didoné ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Root Dentin

Increased, Directed Osteoblast Adhesion at Nanophase Ti and Ti6Al4V Particle Boundaries

2003 ◽  
Vol 806 ◽  
Author(s):  
Thomas J. Webster ◽  
Jeremiah U. Ejiofor
Keyword(s):  
Carbon Nanofibers ◽  
Metal Particle ◽  
Glycolic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Orthopedic Implant ◽  
Grain Sizes ◽  
Nanophase Materials ◽  
Osteoblast Adhesion

ABSTRACTIncreased functions of osteoblasts (bone-forming cells) have been demonstrated on nanophase compared to conventional ceramics (specifically, alumina, titania, and hydroxyapatite), polymers (such as poly-lactic-glycolic acid and polyurethane), carbon nanofibers, and composites thereof. Nanophase materials are materials that simulate dimensions of constituent components of bone since they possess particle or grain sizes less than 100 nm. However, to date, interactions of osteoblasts on nanophase compared to conventional metals remain to be elucidated. For this reason, the objective of the present in vitro study was to design, fabricate, and evaluate osteoblast adhesion on nanophase metals (specifically, Ti and Ti6Al4V). Results of this study provided the first evidence of increased osteoblast adhesion on nanophase compared to conventional Ti-based metals. Moreover, directed osteoblast adhesion was observed preferentially at metal particle boundaries. It is speculated that since more particle boundaries were created through the use of nanophase compared to conventional metals, increased osteoblast adhesion resulted. Because adhesion is a necessary prerequisite for subsequent functions of osteoblasts (such as deposition of calcium-containing mineral), the present study suggests that Ti-based nanophase metals should be further considered for orthopedic implant applications.

scholarly journals In vitro study of sirolimus release from nonwoven PLLA matrices

2018 ◽  
Vol 4 (1) ◽  
pp. 591-594
Author(s):  
Sabine Illner ◽  
Stefanie Kohse ◽  
Claudia Michaelis ◽  
Thomas Reske ◽  
Niels Grabow ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Volume Ratio ◽  
In Vitro Study ◽  
Complete Wetting ◽  
In Vitro Drug Release ◽  
Spray Coatings ◽  
Plasma Pretreatment ◽  
Predetermined Time

AbstractSirolimus incorporated nonwoven polymer matrices were fabricated via electrospinning. Release kinetics considering different fiber diameters and layer thicknesses were investigated. In vitro drug release profiles were evaluated by measuring the drug concentration in an established drug release medium (0.9% saline solution with additives, not buffered) at predetermined time points. Furthermore, an NH3-plasma pretreatment was examined to ensure complete wetting from the beginning of the study. In comparison to thin drug-loaded PLLA spray coatings it was shown that the release of sirolimus is diffusion- and degradation-controlled regardless of the surface-to-volume ratio, though fiber diameters or a hydrophilization can affect its release kinetics.

scholarly journals Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery

2020 ◽  
Vol 21 (19) ◽  
pp. 7312 ◽  
Author(s):  
György Babos ◽  
Joanna Rydz ◽  
Michal Kawalec ◽  
Magdalena Klim ◽  
Andrea Fodor-Kardos ◽  
...  
Keyword(s):  
Drug Release ◽  
Glycolic Acid ◽  
Release Kinetics ◽  
Solvent Evaporation Method ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene ◽  
Average Size ◽  
Dual Drug

Dual drug-loaded nanotherapeutics can play an important role against the drug resistance and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co-encapsulated by tailor-made poly([R,S]-3-hydroxybutyrate) (PHB) using an emulsion–solvent evaporation method. Subsequent poly(ethylene glycol) (PEG) conjugation onto nanoparticles was applied to make the nanocarriers stealth and to improve their drug release characteristics. Monodisperse PHB–sorafenib–doxorubicin nanoparticles had an average size of 199.3 nm, which was increased to 250.5 nm after PEGylation. The nanoparticle yield and encapsulation efficiencies of drugs decreased slightly in consequence of PEG conjugation. The drug release of the doxorubicin was beneficial, since it was liberated faster in a tumor-specific acidic environment than in blood plasma. The PEG attachment decelerated the release of both the doxorubicin and the sorafenib, however, the release of the latter drug remained still significantly faster with increased initial burst compared to doxorubicin. Nevertheless, the PEG–PHB copolymer showed more beneficial drug release kinetics in vitro in comparison with our recently developed PEGylated poly(lactic-co-glycolic acid) nanoparticles loaded with the same drugs.

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