scholarly journals Combination of enzymes and flow perfusion conditions improves osteogenic differentiation of bone marrow stromal cells cultured upon starch/poly(ε-caprolactone) fiber meshes

2010 ◽  
Vol 9999A ◽  
pp. NA-NA
Author(s):  
Ana M. Martins ◽  
Anita Saraf ◽  
Rui A. Sousa ◽  
Catarina M. Alves ◽  
Antonios G. Mikos ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Flow Perfusion ◽  
Cells Cultured

Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg–Gly–Asp modified hydrogels without dexamethasone and β-glycerol phosphate

Biomaterials ◽  
2005 ◽  
Vol 26 (17) ◽  
pp. 3645-3654 ◽  
Author(s):  
Heungsoo Shin ◽  
Johnna S. Temenoff ◽  
Gregory C. Bowden ◽  
Kyriacos Zygourakis ◽  
Mary C. Farach-Carson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Glycerol Phosphate ◽  
Cells Cultured ◽  
Rat Bone

scholarly journals Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice

2021 ◽  
Author(s):  
Daqian Wan ◽  
Songtao Ai ◽  
Huoniu Ouyang ◽  
Liming Cheng
Keyword(s):  
Bone Marrow ◽  
Bone Loss ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Marrow Microenvironment ◽  
Marrow Stromal Cells ◽  
Senile Osteoporosis ◽  
Aged Mice ◽  
Old Mice

AbstractSenile osteoporosis can cause bone fragility and increased fracture risks and has been one of the most prevalent and severe diseases affecting the elderly population. Bone formation depends on the proper osteogenic differentiation of bone marrow stromal cells (BMSCs) in the bone marrow microenvironment, which is generated by the functional relationship among different cell types in the bone marrow. With aging, bone marrow provides signals that repress osteogenesis. Finding the signals that oppose BMSC osteogenic differentiation from the bone marrow microenvironment and identifying the abnormal changes in BMSCs with aging are key to elucidating the mechanisms of senile osteoporosis. In a pilot experiment, we found that 4-1BBL and 4-1BB were more abundant in bone marrow from aged (18-month-old) mice than young (6-month-old) mice. Meanwhile, significant bone loss was observed in aged mice compared with young mice. However, very little data have been generated regarding whether high-level 4-1BB/4-1BBL in bone marrow was associated with bone loss in aged mice. In the current study, we found upregulation of 4-1BB in the BMSCs of aged mice, which resulted in the attenuation of the osteogenic differentiation potential of BMSCs from aged mice via the p38 MAPK-Dkk1 pathway. More importantly, bone loss of aged mice could be rescued through the blockade of 4-1BB signaling in vivo. Our study will benefit not only our understanding of the pathogenesis of age-related trabecular bone loss but also the search for new targets to treat senile osteoporosis.

STIMULATORY EFFECTS OF CARTILAGE-DERIVED MORPHOGENETIC PROTEINS 1 AND 2 ON OSTEOGENIC DIFFERENTIATION OF BONE MARROW STROMAL CELLS

Cytokine ◽  
2000 ◽  
Vol 12 (11) ◽  
pp. 1630-1638 ◽  
Author(s):  
Reinhard Gruber ◽  
Christian Mayer ◽  
Waltraud Schulz ◽  
Winfried Graninger ◽  
Meinrad Peterlik ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells
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