scholarly journals The impact of hyaluronic acid oligomer content on physical, mechanical, and biologic properties of divinyl sulfone-crosslinked hyaluronic acid hydrogels

2010 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Samir Ibrahim ◽  
Qian K. Kang ◽  
Anand Ramamurthi
Keyword(s):  
Hyaluronic Acid ◽  
Divinyl Sulfone ◽  
The Impact

scholarly journals Droplet-Assisted Microfluidic Fabrication and Characterization of Multifunctional Polysaccharide Microgels Formed by Multicomponent Reactions

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1055 ◽  
Author(s):  
Nicolas Hauck ◽  
Nalin Seixas ◽  
Silvia Centeno ◽  
Raimund Schlüßler ◽  
Gheorghe Cojoc ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Multicomponent Reactions ◽  
Building Blocks ◽  
Correlation Spectroscopy ◽  
Droplet Microfluidics ◽  
Phase Imaging ◽  
Colloidal Probe ◽  
Young’S Moduli ◽  
Depth Analysis ◽  
The Impact

Polysaccharide-based microgels have broad applications in multi-parametric cell cultures, cell-free biotechnology, and drug delivery. Multicomponent reactions like the Passerini three-component and the Ugi four-component reaction are shown in here to be versatile platforms for fabricating these polysaccharide microgels by droplet microfluidics with a narrow size distribution. While conventional microgel formation requires pre-modification of hydrogel building blocks to introduce certain functionality, in multicomponent reactions one building block can be simply exchanged by another to introduce and extend functionality in a library-like fashion. Beyond synthesizing a range of polysaccharide-based microgels utilizing hyaluronic acid, alginate and chitosan, exemplary in-depth analysis of hyaluronic acid-based Ugi four-component gels is conducted by colloidal probe atomic force microscopy, confocal Brillouin microscopy, quantitative phase imaging, and fluorescence correlation spectroscopy to elucidate the capability of microfluidic multicomponent reactions for forming defined polysaccharide microgel networks. Particularly, the impact of crosslinker amount and length is studied. A higher network density leads to higher Young’s moduli accompanied by smaller pore sizes with lower diffusion coefficients of tracer molecules in the highly homogeneous network, and vice versa. Moreover, tailored building blocks allow for crosslinking the microgels and incorporating functional groups at the same time as demonstrated for biotin-functionalized, chitosan-based microgels formed by Ugi four-component reaction. To these microgels, streptavidin-labeled enzymes are easily conjugated as shown for horseradish peroxidase (HRP), which retains its activity inside the microgels.

scholarly journals Validation of technological process of preparation hymoding cream with hyaluronic acid

2021 ◽  
pp. 27-35
Author(s):  
Т. Г. Ярних ◽  
Г. М. Мельник ◽  
О. А. Рухмакова
Keyword(s):  
Risk Assessment ◽  
Hyaluronic Acid ◽  
Technological Process ◽  
Critical Parameters ◽  
Documentary Evidence ◽  
Technological Parameters ◽  
Eligibility Criteria ◽  
Critical Control Points ◽  
Definition Of ◽  
The Impact

To date, in the mass production of medicines both in pharmaceutical companies and in pharmacies, more and more attention is paid to the practice of process validation. Validation is a key condition for the implementation of Good Manufacturing (GMP) and Pharmacy (GPP) practices, the standards of which are mandatory for medicines worldwide and in Ukraine. The aim of the work – validation of the technological process of preparation extemporaneous hymoding cream with hyaluronic acid in order to obtain documentary evidence of effective reproduction of the preparation of this medicine. The study design is based on research on the development of dosage form technology, analysis of the impact of critical manufacturing points and evaluation of their impact on the final quality of the cream, taking into account the requirements of GPP. The object of validation is the technological process of preparation hymoding cream with hyaluronic acid. The validation procedure was performed on 3 experimental batches of the medicine. In order to check and optimize the selected technological process of preparation hymoding cream in pharmacies, its validation was carried out. According to the calculated quantities of the components of the studied cream, as well as the identified critical parameters, three batches of the medicine of 100.00 g were developed. On the series of cream, the optimization of technological parameters, testing of critical parameters for all planned stages of production with the definition of eligibility criteria and validation scheme was carried out. Acceptance criteria for all critical parameters were determined during the optimization of technology on batches of the studied medicine. The general risk assessment was carried out at the stage of pharmaceutical development according to the procedure «identification – analysis – risk assessment» to determine the scheme of validation work on batches of the medicine. During the technological process, critical indicators were checked and appropriate forms were filled out. A study on the validation of the technological process of preparation hymoding cream with hyaluronic acid in pharmacies was performed. Documentary evidence of effective reproduction of the manufacture of this medicine has been obtained. A comprehensive analysis of the developed manufacturing process makes it possible to identify critical control points that minimize the occurrence of possible risks in the manufacture of the investigated medicine. According to the results of the research, it can be concluded that the developed cream with hyaluronic acid meets the requirements of State Pharmacopoeia of Ukraine in all quality indicators, which allows to recommend it for use in dermatology.

scholarly journals Synoviology: a new chapter entitled to joints care

2017 ◽  
Vol 8 (3) ◽  
pp. 1-10 ◽  
Author(s):  
Beniamino Palmieri ◽  
Thierry Conrozier ◽  
Maria Vadalà ◽  
Carmen Laurino
Keyword(s):  
Hyaluronic Acid ◽  
Synovial Membrane ◽  
Therapeutic Options ◽  
Evidence Based ◽  
Medical Sciences ◽  
Medical Treatments ◽  
Disease Therapy ◽  
Quality And Reliability ◽  
The Impact ◽  
And Cartilage

In order to extensively investigate on the synovial membrane – related diseases, we outlined a specific medical branch named “Synoviology”, targeted to the physiopathology and therapy of synovial membrane dysfunction. We searched Pubmed/Medline using the terms “synovial disease”, “therapy”, “synovial membrane”, “joints” and “drugs”, alone and combined. Selected papers from 1960 to 2015 were chosen based on their content (evidence-based quality and reliability). Clinical and experimental articles were included. Viscosupplementation with structurally different hyaluronic acid compounds, for restoration of the synovial membrane, and cartilage. The impact of other old and new medical treatments either locally or systemically administered was also included. Synoviology integrates biological, clinical and biochemical info for the progress of new therapeutic options in osteo-articular pathology.Asian Journal of Medical Sciences Vol.8(3) 2017 1-10

scholarly journals The Impact of Excluding Patients with End-Stage Knee Disease in Intra-Articular Hyaluronic Acid Trials: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 36 (1) ◽  
pp. 147-161 ◽  
Author(s):  
Mathew Nicholls ◽  
Peter Shaw ◽  
Faizan Niazi ◽  
Mohit Bhandari ◽  
Asheesh Bedi
Keyword(s):  
Systematic Review ◽  
Hyaluronic Acid ◽  
Meta Analysis ◽  
End Stage ◽  
The Impact

scholarly journals The impact of hyaluronic acid coating on the surface properties of model contact lenses

2016 ◽  
Vol 4 ◽  
Author(s):  
Korogiannaki Myrto ◽  
Samsom Michael ◽  
Jones Lyndon ◽  
Schmidt Tannin ◽  
Sheardown Heather
Keyword(s):  
Hyaluronic Acid ◽  
Surface Properties ◽  
Contact Lenses ◽  
The Impact ◽  
Acid Coating
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