Bone grafts cultured with bone marrow stromal cells for the repair of critical bone defects: An experimental study in mice

2009 ◽  
Vol 90A (4) ◽  
pp. 1218-1229 ◽  
Author(s):  
Aline Dumas ◽  
Marie-Françoise Moreau ◽  
Romain K. Ghérardi ◽  
Michel F. Baslé ◽  
Daniel Chappard
Keyword(s):  
Bone Marrow ◽  
Experimental Study ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Grafts ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Critical Bone Defects

scholarly journals Restoration of Critical-Sized Defects in the Rabbit Mandible Using Autologous Bone Marrow Stromal Cells Hybridized with Nano-β-tricalcium Phosphate/Collagen Scaffolds

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xuehui Zhang ◽  
Mingming Xu ◽  
Xinggang Liu ◽  
Feng Zhang ◽  
Yan Wei ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Marrow Stromal Cells ◽  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Collagen Scaffolds ◽  
Autologous Bone

Nano-β-tricalcium phosphate/collagen (n-β-TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n-β-TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n-β-TCP/Col scaffolds exhibited high biocompatibilityin vitro. The introduction of BMSCs expandedin vitroto the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n-β-TCP/Col scaffolds have the potential to be applied in bone tissue engineering.

Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate

2008 ◽  
Vol 368-372 ◽  
pp. 1235-1237 ◽  
Author(s):  
Lei Liu ◽  
Run Liang Chen ◽  
Yun Feng Lin ◽  
Wei Dong Tian ◽  
Sheng Wei Li
Keyword(s):  
Electron Microscopy ◽  
Tissue Engineering ◽  
Bone Marrow ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Marrow Stromal Cells ◽  
Bone Defects ◽  
Marrow Stromal Cells

Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility, biological degradability, and porosity. This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold. In this study, critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP. The resulting grafts were examined by X-ray, histological examination, semi-quantitative analysis of osteogenesis, immunochemical examination (collagen type I and III), scanning electron microscopy and transmission electron microscopy. The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.

scholarly journals Repair of orbital bone defects in canines using grafts of enriched autologous bone marrow stromal cells

2014 ◽  
Vol 12 (1) ◽  
pp. 123 ◽  
Author(s):  
Yefei Wang ◽  
Xiaoping Bi ◽  
Huifang Zhou ◽  
Yuan Deng ◽  
Jing Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Autologous Bone

Repair of segmental mandibular bone defects in sheep using bone marrow stromal cells and autologous serum scaffold: a pilot study

2015 ◽  
Vol 42 (12) ◽  
pp. 1143-1151 ◽  
Author(s):  
Lorena Gallego ◽  
Marcos Pérez-Basterrechea ◽  
Luis García-Consuegra ◽  
María Álvarez-Viejo ◽  
Joaquim Megías ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pilot Study ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Autologous Serum ◽  
Mandibular Bone
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