scholarly journals Designing tailored biomaterial surfaces to direct keratinocyte morphology, attachment, and differentiation

2009 ◽  
Vol 90A (4) ◽  
pp. 999-1009 ◽  
Author(s):  
K. A. Bush ◽  
P. F. Driscoll ◽  
E. R. Soto ◽  
C. R. Lambert ◽  
W. G. McGimpsey ◽  
...  
Keyword(s):  
Biomaterial Surfaces

Corrosion and mechanical behavior of plasma nitrated metallic biomaterial surfaces

2021 ◽  
Author(s):  
S.P. Venkatesan ◽  
Jeya Jeevahan ◽  
M. Purusothaman ◽  
S. Venkatesh ◽  
M. Rakesh Vimal
Keyword(s):  
Mechanical Behavior ◽  
Biomaterial Surfaces ◽  
Metallic Biomaterial

scholarly journals High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhou Fang ◽  
Junjian Chen ◽  
Ye Zhu ◽  
Guansong Hu ◽  
Haoqian Xin ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
High Throughput ◽  
High Throughput Screening ◽  
Rational Design ◽  
Click Reaction ◽  
Reaction Times ◽  
Great Promise ◽  
Biomaterial Surfaces

AbstractPeptides are widely used for surface modification to develop improved implants, such as cell adhesion RGD peptide and antimicrobial peptide (AMP). However, it is a daunting challenge to identify an optimized condition with the two peptides showing their intended activities and the parameters for reaching such a condition. Herein, we develop a high-throughput strategy, preparing titanium (Ti) surfaces with a gradient in peptide density by click reaction as a platform, to screen the positions with desired functions. Such positions are corresponding to optimized molecular parameters (peptide densities/ratios) and associated preparation parameters (reaction times/reactant concentrations). These parameters are then extracted to prepare nongradient mono- and dual-peptide functionalized Ti surfaces with desired biocompatibility or/and antimicrobial activity in vitro and in vivo. We also demonstrate this strategy could be extended to other materials. Here, we show that the high-throughput versatile strategy holds great promise for rational design and preparation of functional biomaterial surfaces.

scholarly journals Ion Beam Nanopatterning of Biomaterial Surfaces

2021 ◽  
Vol 11 (14) ◽  
pp. 6575
Author(s):  
Yu Yang ◽  
Adrian Keller
Keyword(s):  
Material Properties ◽  
Ion Beam ◽  
The Self ◽  
Solid Surfaces ◽  
Beam Irradiation ◽  
Ion Beam Irradiation ◽  
Future Directions ◽  
Self Organized ◽  
Functional Surfaces ◽  
Biomaterial Surfaces

Ion beam irradiation of solid surfaces may result in the self-organized formation of well-defined topographic nanopatterns. Depending on the irradiation conditions and the material properties, isotropic or anisotropic patterns of differently shaped features may be obtained. Most intriguingly, the periodicities of these patterns can be adjusted in the range between less than twenty and several hundred nanometers, which covers the dimensions of many cellular and extracellular features. However, even though ion beam nanopatterning has been studied for several decades and is nowadays widely employed in the fabrication of functional surfaces, it has found its way into the biomaterials field only recently. This review provides a brief overview of the basics of ion beam nanopatterning, emphasizes aspects of particular relevance for biomaterials applications, and summarizes a number of recent studies that investigated the effects of such nanopatterned surfaces on the adsorption of biomolecules and the response of adhering cells. Finally, promising future directions and potential translational challenges are identified.

scholarly journals Polysaccharide Films Built by Simultaneous or Alternate Spray: A Rapid Way to Engineer Biomaterial Surfaces

Langmuir ◽  
2012 ◽  
Vol 28 (22) ◽  
pp. 8470-8478 ◽  
Author(s):  
G. Cado ◽  
H. Kerdjoudj ◽  
A. Chassepot ◽  
M. Lefort ◽  
K. Benmlih ◽  
...  
Keyword(s):  
Biomaterial Surfaces

Cell Biology and Molecular Mechanisms in Artificial Device Infections

1993 ◽  
Vol 16 (11) ◽  
pp. 755-764 ◽  
Author(s):  
A.G. Gristina ◽  
G. Giridhar ◽  
B.L Gabriel ◽  
P.T. Naylor ◽  
Q.N. Myrvik
Keyword(s):  
Bacterial Adhesion ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Total Joint Replacement ◽  
Total Artificial Heart ◽  
Implant Surface ◽  
Microbial Adhesion ◽  
Major Barrier ◽  
Tissue Integration ◽  
Biomaterial Surfaces

Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacement and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barrier to the extended use of these devices is bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Adhesion-mediated infections are extremely resistant to antibiotics and host defenses and frequently persist until the biomaterial or foreign body is removed. The pathogenesis of adhesive infections is related, in part, to preferential colonization of “inert” substrata whose surfaces are not integrated with healthy tissues composed of living cells and intact extracellular polymers. Tissue integration is an interesting parallel to microbial adhesion and is a desired phenomenon for the biocompatibility of certain implants and biomaterials. Tissue integration requires a form of eukaryocytic adhesion or compatibility with possible chemical integration to an implant surface. Many of the fundamental principles of interfacial science apply to both microbial adhesion and to tissue integration and are general to and independent of the substratum materials involved. Interactions of biomaterials with bacteria and tissue cells are directed not only by specific receptors and outer membrane molecules on the cell surface, but also by the atomic geometry and electronic state of the biomaterial surface. An understanding of these mechanisms is important to all fields of medicine and is derived from and relevant to studies in microbiology, biochemistry, and physics. Modifications of biomaterial surfaces at an atomic level will allow the programming of cell-to-substratum events, thereby diminishing infection by enhancing tissue compatibility or integration, or by directly inhibiting bacterial adhesion.

Analysis of the effect of the size of three-dimensional micro-geometric structures on physical adhesion phenomena using microprint technique

2018 ◽  
Vol 41 (5) ◽  
pp. 277-283 ◽  
Author(s):  
Akiko Oota-Ishigaki ◽  
Toru Masuzawa ◽  
Kazuaki Nagayama
Keyword(s):  
Shear Rate ◽  
Secondary Flow ◽  
Thrombus Formation ◽  
Three Dimensional ◽  
Flow Simulation ◽  
Quantitative Relationship ◽  
Bottom Surface ◽  
Material Surface ◽  
Computational Fluid Dynamics Analysis ◽  
Biomaterial Surfaces

Thrombus formation on biomaterial surfaces with microstructures is complex and not fully understood. We have studied the micro-secondary flow around microstructures that causes components of blood to adhere physically in a low Reynolds number region. The purpose of this study was to investigate the effect of micro-column size on the adhesion phenomena and show a quantitative relationship between the micro-secondary flow and physical adhesion phenomena, considering microstructures of various sizes. The flow simulation and quantitative assessment of adhesion rates around micro-columns was conducted using four sizes of micro-columns. This study also calculated the vectors of micro-secondary flow and average shear rate around a micro-column using a computational fluid dynamics analysis. The simulation showed the micro-secondary flow toward the bottom surface at upstream side and low shear rate distribution generated around a micro-column. Furthermore, physical adhesion tests were conducted using microbeads and a perfusion circuit to examine the size effect of the micro-columns on the physical adhesion. The results showed that the average adhesion rate around the micro-column increases with the associated size increase of the micro-column. Our results indicate that quantification of micro-secondary flow on a material surface with microstructures of several sizes and shapes (such as in a rough surface) is important for the evaluation of the adhesion phenomenon even though the surface roughness value on the material surface is small.

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