Injection of a novel synthetic hydrogel preserves left ventricle function after myocardial infarction

2009 ◽  
Vol 90A (2) ◽  
pp. 472-477 ◽  
Author(s):  
Xue-Jun Jiang ◽  
Tao Wang ◽  
Xiao-Yan Li ◽  
De-Qun Wu ◽  
Zhao-Bin Zheng ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricle ◽  
Left Ventricle Function ◽  
Synthetic Hydrogel ◽  
Ventricle Function

P4524His bundle pacing in patients pacemaker indication and with mildly reduced ejection fraction

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
R Gardas ◽  
G Jarosinki ◽  
R Sznjader ◽  
J Biernat ◽  
K Goscinska-Bis ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Left Ventricle ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Left Ventricle Function ◽  
Reduced Ejection Fraction ◽  
Permanent Pacing ◽  
Qrs Duration ◽  
Ventricle Function

Abstract Background Right ventricular pacing (RVP) can be harmful and in a number of patients leads to deterioration of left ventricle function. The deleterious effect of RVP is particularly visible in patients with reduced ejection fraction. His bundle pacing (HBP) allows ventricular stimulation without electrical and mechanical dyssynchrony and should not be associated with deterioration of left ventricle function. In some patients HBP restores electrical and mechanical synchrony. Objective The aim of the study is to evaluate effect of HBP on left ventricle function in patient with reduced left ventricle ejection fraction (LVEF. Methods Twenty-one patients with indication for permanent pacing and with (LVEF) between 35 and 50% were included into the study. Age 71,9±10,44. Men 76,2%. 13 (61,9%) patients with permanent atrial fibrillation. In 33,3% of patients there were intraventricular conduction delay (IVCD), 3 (14,3%) with LBBB, 3 (14,3%) with RBBB and 1 (4,8%) with nonspecific IVCD. 6 patients were upgraded from previously implanted pacemaker. Mean QRS duration 133,6±37,85. Baseline ejection fraction (EF) 42,6±3,21%. Clinical and echocardiographic evaluation were performed at baseline and after 6–12 months of follow up. Results QRS duration narrowed from 133,6±37,85ms to 114,3±16,90ms (p=0,033) with HBP. HBP was associated with reduction of end systolic left ventricular volume (LVES) from 91,5±31,10ml to 75,9±38,56ml (p=0,0058). EF improved from 42,6±3,21% to 48,3±7,39% (p=0,0006). Improvement in EF in patients without myocardial infarction (MI) was better (42,6±3,23% to 49,5±8,04%, p=0,0053) than in patients with MI (42,6±3,37% to 47,0±6,79%, p=0,062). Increase in EF was also better in patients with atrial fibrillation (42,7±3,19% to 49,9±8,20%, p=0,0017) than int patients with sinus rhythm (42,4±3,46% to 45,6±5,28%, p=0,17). Functional capacity assessed by NYHA class improved significantly from 2,4±0,59 to 1,7±0,58. Ejection Fraction Conclusion His bundle pacing is associated with th significant clinical and echocardiographic improvement in patients with mildly reduced left ventricular ejection fraction and indication for permanent pacing. After 6–12 moths of HBP pacing the improvement in EF is greater in patients with atrial fibrillation and without myocardial infarction.

scholarly journals Transplantation of Bone Marrow Derived Progenitor Cells in Acute Myocardial Infarction. The First Results

2005 ◽  
Vol 48 (3-4) ◽  
pp. 153-155 ◽  
Author(s):  
Radek Pudil ◽  
Jan Vojáček ◽  
Stanislav Filip ◽  
Pavel Měřička ◽  
Josef Šťásek ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Bone Marrow ◽  
Left Ventricle ◽  
Bone Marrow Cells ◽  
Thrombus Formation ◽  
Autologous Bone Marrow ◽  
Left Ventricle Function ◽  
Direct Stenting ◽  
Ventricle Function

The intracoronary administration of autologous bone marrow cells (BMCs) has been shown to improve the left ventricle function in the course of acute myocardial infarction. Therefore we have started a clinical trial using transplantation of BMCs in the acute phase of myocardial infarction. The aim of our study is to assess the feasibility and safety of this procedure, and effect on the left ventricle function of these patients. We describe the first experience in two patients with acute myocardial infarction reperfused using direct stenting. The aspiration of bone marrow from the sternum provided sufficient amount of the cells for transplantation. No serious ischemia and no changes in coronary artery patency were detected after intracoronary infusion. The left ventricle ejection fraction was increasing throughout the time of three-month follow-up. No other complications (ventricular arrhythmias, reinfarction, thrombus formation) were detected.

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