Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+and V3+are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+

2008 ◽  
Vol 86A (4) ◽  
pp. 905-913 ◽  
Author(s):  
Marco Caicedo ◽  
Joshua J. Jacobs ◽  
Anand Reddy ◽  
Nadim James Hallab
Keyword(s):  
Dna Damage ◽  
T Cells ◽  
Metal Ion ◽  
Jurkat T Cells ◽  
Apoptosis And Necrosis

Phototoxicity and DNA damage induced by the cosmetic ingredient chemical azulene in human Jurkat T-cells

2004 ◽  
Vol 562 (1-2) ◽  
pp. 143-150 ◽  
Author(s):  
Lei Wang ◽  
Jian Yan ◽  
Shuguang Wang ◽  
Hari Cohly ◽  
Peter P Fu ◽  
...  
Keyword(s):  
Dna Damage ◽  
T Cells ◽  
Jurkat T Cells

scholarly journals Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells

2010 ◽  
Vol 193 (1) ◽  
pp. 108-114 ◽  
Author(s):  
S.H. Inayat-Hussain ◽  
K.M. Chan ◽  
N.F. Rajab ◽  
L.B. Din ◽  
S.C. Chow ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
T Cells ◽  
Jurkat T Cells ◽  
Caspase 2

The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells

2009 ◽  
pp. 1-8
Author(s):  
Jing-Lei Qu ◽  
Xiu-Juan Qu ◽  
Ming-Fang Zhao ◽  
Yue-E Teng ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Ubiquitin Ligases ◽  
Jurkat T Cells ◽  
Induced Apoptosis

scholarly journals GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lauren A. Callender ◽  
Johannes Schroth ◽  
Elizabeth C. Carroll ◽  
Conor Garrod-Ketchley ◽  
Lisa E. L. Romano ◽  
...  
Keyword(s):  
Dna Damage ◽  
T Cells ◽  
T Cell ◽  
Mitochondrial Biogenesis ◽  
Cell Manipulation ◽  
Th2 Cells ◽  
Related Factor ◽  
Mitochondrial Mass ◽  
T Helper 2 ◽  
And Function

AbstractGATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4+ T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, proliferation and maintenance in other T cell and non-T cell lineages. Here we show a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK. Activated AMPK increases expression of PPARG coactivator 1 alpha (PPARGC1A or PGC1α protein) at the level of transcription and GATA3 at the level of translation, while DNA damage enhances expression of nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2). PGC1α, GATA3 and NRF2 complex together with the ATR to promote mitochondrial biogenesis. These findings extend the pleotropic interactions of GATA3 and highlight the potential for GATA3-targeted cell manipulation for intervention in CD4+ T cell viability and function after DNA damage.

scholarly journals Amorphous–Crystalline Calcium Phosphate Coating Promotes In Vitro Growth of Tumor-Derived Jurkat T Cells Activated by Anti-CD2/CD3/CD28 Antibodies

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3693
Author(s):  
Yurii P. Sharkeev ◽  
Ekaterina G. Komarova ◽  
Valentina V. Chebodaeva ◽  
Mariya B. Sedelnikova ◽  
Aleksandr M. Zakharenko ◽  
...  
Keyword(s):  
T Cells ◽  
Calcium Phosphate ◽  
Biological Effects ◽  
Electrical Potential ◽  
Biological Properties ◽  
Modern Trend ◽  
Calcium Phosphate Coating ◽  
Jurkat T Cells ◽  
Micro Arc Oxidation

A modern trend in traumatology, orthopedics, and implantology is the development of materials and coatings with an amorphous–crystalline structure that exhibits excellent biocopatibility. The structure and physico–chemical and biological properties of calcium phosphate (CaP) coatings deposited on Ti plates using the micro-arc oxidation (MAO) method under different voltages (200, 250, and 300 V) were studied. Amorphous, nanocrystalline, and microcrystalline statesof CaHPO4 and β-Ca2P2O7were observed in the coatings using TEM and XRD. The increase in MAO voltage resulted in augmentation of the surface roughness Ra from 2.5 to 6.5 µm, mass from 10 to 25 mg, thickness from 50 to 105 µm, and Ca/P ratio from 0.3 to 0.6. The electrical potential (EP) of the CaP coatings changed from −456 to −535 mV, while the zeta potential (ZP) decreased from −53 to −40 mV following an increase in the values of the MAO voltage. Numerous correlations of physical and chemical indices of CaP coatings were estimated. A decrease in the ZP magnitudes of CaP coatings deposited at 200–250 V was strongly associated with elevated hTERT expression in tumor-derived Jurkat T cells preliminarily activated with anti-CD2/CD3/CD28 antibodies and then contacted in vitro with CaP-coated samples for 14 days. In turn, in vitro survival of CD4+ subsets was enhanced, with proinflammatory cytokine secretion of activated Jurkat T cells. Thus, the applied MAO voltage allowed the regulation of the physicochemical properties of amorphous–crystalline CaP-coatings on Ti substrates to a certain extent. This method may be used as a technological mechanism to trigger the behavior of cells through contact with micro-arc CaP coatings. The possible role of negative ZP and Ca2+ as effectors of the biological effects of amorphous–crystalline CaP coatings is discussed. Micro-arc CaP coatings should be carefully tested to determine their suitability for use in patients with chronic lymphoid malignancies.

scholarly journals Semi-purified extracts of Commelina benghalensis (Commelinaceae) induce apoptosis and cell cycle arrest in Jurkat-T cells

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Kgomotso Welheminah Lebogo ◽  
Matlou Phineas Mokgotho ◽  
Victor Patrick Bagla ◽  
Thabe Moses Matsebatlela ◽  
Vusi Mbazima ◽  
...  
Keyword(s):  
Cell Cycle ◽  
T Cells ◽  
Cell Cycle Arrest ◽  
Jurkat T Cells ◽  
Commelina Benghalensis ◽  
Cycle Arrest
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