Fabrication of macroporous carbonate apatite foam by hydrothermal conversion of α-tricalcium phosphate in carbonate solutions

2008 ◽  
Vol 87A (4) ◽  
pp. 957-963 ◽  
Author(s):  
H. Wakae ◽  
A. Takeuchi ◽  
K. Udoh ◽  
S. Matsuya ◽  
M. L. Munar ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Carbonate Apatite ◽  
Hydrothermal Conversion ◽  
Carbonate Solutions

scholarly journals Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

2019 ◽  
Vol 13 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Fadilah Darus ◽  
Mariatti Jaafar ◽  
Nurazreena Ahmad
Keyword(s):  
Compressive Strength ◽  
Aqueous Solutions ◽  
Tricalcium Phosphate ◽  
Average Pore Size ◽  
Carbonate Content ◽  
Precipitation Reaction ◽  
Carbonate Apatite ◽  
Hydrothermal Conversion ◽  
Average Pore ◽  
Beta Tricalcium Phosphate

The aim of this study is to fabricate CO3Ap scaffolds using a dissolution-precipitation reaction during hydrothermal treatment. Beta-tricalcium phosphate (?-TCP) was used as a precursor instead of the commonly used alpha-tricalcium phosphate (?-TCP). Here, the CO3Ap scaffold fabrication was accomplished in two steps: i) fabrication of ?-TCP scaffold using a combination of direct foaming and a sacrificial template and ii) hydrothermal conversion of the ?-TCP scaffold at 200?C in 2mol/l NaHCO3 and Na2CO3 aqueous solutions for 2-10 days. The effect of two different solutions was identified in the dissolution-precipitation reaction. CO3Ap scaffold with 8.95wt.% carbonate content was successfully fabricated using a NaHCO3 solution. The average pore size of the scaffold was approximately 180 ?m with 72% porosity. The average compressive strength of the CO3Ap scaffold was 0.7MPa. Based on the compressive strength and carbonate content results, NaHCO3 aqueous solutions were chosen as carbonate sources for phase transformation to fabricate a CO3Ap scaffold over 6 days.

scholarly journals Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and β-Tricalcium Phosphate Bone Substitutes

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1993 ◽  
Author(s):  
Kunio Ishikawa ◽  
Youji Miyamoto ◽  
Akira Tsuchiya ◽  
Koichiro Hayashi ◽  
Kanji Tsuru ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Bone Substitutes ◽  
Physiological Solution ◽  
Tissue Response ◽  
Histological Evaluation ◽  
Carbonate Apatite ◽  
Artificial Bone ◽  
New Bone Formation

Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone®), carbonate apatite (CO3Ap; Cytrans®), and β-tricalcium phosphate (β-TCP; Cerasorb®), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone® (HAp) and Cerasorb® (β-TCP) were porous, whereas Cytrans® (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone® (HAp), Cytrans® (CO3Ap), and Cerasorb® (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m2/g, 18.2 m2/g, and 1.0 m2/g, respectively. These values are consistent with the fact that both Neobone® (HAp) and Cerasorb® (β-TCP) are sintered ceramics, whereas Cytrans® (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship’s lacunae was fastest in CO3Ap (Cytrans®), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb®). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship’s lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans®) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans®) was confirmed. β-TCP (Cerasorb®) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans®) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone.

scholarly journals Effect of Soaking Time on the Phase Transformation of Porous Biphasic β-Tricalcium Phosphate/Carbonate Apatite Scaffold

2019 ◽  
Vol 30 (Supp.2) ◽  
pp. 65-75
Author(s):  
Nur Nadhirah Muhaime ◽  
◽  
Ira Artillia ◽  
Nurazreena Ahmad ◽  
◽  
...  
Keyword(s):  
Phase Transformation ◽  
Tricalcium Phosphate ◽  
Carbonate Apatite ◽  
Soaking Time ◽  
Phosphate Carbonate

Ca-P Formation on Poly-L-Lactide/β-Tricalcium Phosphate Composite Scaffold in Simulated Body Fluid

2007 ◽  
Vol 342-343 ◽  
pp. 689-692
Author(s):  
Yun Qing Kang ◽  
Guang Fu Yin ◽  
Ke Feng Wang ◽  
Lin Luo ◽  
Ya Dong Yao
Keyword(s):  
Simulated Body Fluid ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Porous Scaffold ◽  
Composite Scaffold ◽  
Typical Feature ◽  
Carbonate Apatite ◽  
Absorption Bands ◽  
Good Ability

Poly-L-lactide/β-tricalcium phosphate (PLLA/β-TCP) porous scaffold fabricated by freeze shrinking/particulate leaching was studied. The scaffold was immersed into simulated body fluid (SBF) for 1, 2, 3 and 4 weeks and analyzed by the SEM, XRD and FT-IR spectroscopy. The ability of inducing Ca-P formation was compared among the scaffolds with different content of β- TCP. SEM shows a typical feature of apatite precipitation. Diffraction peak of new crystal structure was detected by x-ray diffraction (XRD). IR Spectrum in which absorption bands arise from newly formed groups of carbonate apatite can be seen. At the same testing point, higher density of Ca-P crystal can be observed by SEM in scaffold with high content of β-TCP than in low group. Until 3 weeks, Ca-P individual crystal started on the wall of inner pore of pure PLLA. Porous PLLA/β-TCP composite scaffolds also indicate good ability of Ca-P formation in vitro, the ability of which to form apatite was enhanced by addition of each other that has different degradable mechanism.

Bone Marrow Cell Response on Carbonate Apatite/PCL-Coated α-Tricalcium Phosphate Foam

2013 ◽  
Vol 858 ◽  
pp. 7-12
Author(s):  
Thi Bang Le ◽  
Xing Ling Shi ◽  
Ishikawa Kunio ◽  
Radzali Othman
Keyword(s):  
Bone Marrow ◽  
Tricalcium Phosphate ◽  
Bone Marrow Cells ◽  
Cell Attachment ◽  
Marrow Cell ◽  
Research Work ◽  
Biological Properties ◽  
Carbonate Apatite ◽  
Vitro Effect

The aim of this research work was to investigate in vitro effect of the carbonate apatite/poly (ε-caprolactone) (CO3Ap/PCL) on α-tricalcium phosphate (α-TCP) foam was produced by sintering CaCO3and CaHPO42H2O at 1500°C for 5 h. It was then coated with carbonate apatite (CO3Ap)/Poly-ε-caprolactone (PCL) (wt/wt=1/3) to improve both mechanical and biological properties. The initial cell attachment and proliferation of the bone marrow cells were carried out on the α-TCP and CO3Ap/PCL-coated α-TCP foams. The cell proliferation was calculated by AlamarBlue assay. The cells were able to migrate and proliferate well on both α-TCP and CO3Ap/PCL-coated α-TCP foams indicating an excellent biocompatibility. The incorporation of CO3Ap on the coating layer improved cellular attachment and accelerated proliferation. Thus, CO3Ap/PCL-coated α-TCP foam might be a promising candidate as implant material.

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