Initial attachment of osteoblastic cells onto sol-gel derived fluoridated hydroxyapatite coatings

2008 ◽  
Vol 84A (3) ◽  
pp. 769-776 ◽  
Author(s):  
Yongsheng Wang ◽  
Sam Zhang ◽  
Xianting Zeng ◽  
Lwin Lwin Ma ◽  
Khiam Aik Khor ◽  
...  
Keyword(s):  
Sol Gel ◽  
Osteoblastic Cells ◽  
Initial Attachment ◽  
Fluoridated Hydroxyapatite ◽  
Hydroxyapatite Coatings

Adhesion strength of sol–gel derived fluoridated hydroxyapatite coatings

2006 ◽  
Vol 200 (22-23) ◽  
pp. 6350-6354 ◽  
Author(s):  
Sam Zhang ◽  
Zeng Xianting ◽  
Wang Yongsheng ◽  
Cheng Kui ◽  
Weng Wenjian
Keyword(s):  
Adhesion Strength ◽  
Sol Gel ◽  
Fluoridated Hydroxyapatite ◽  
Hydroxyapatite Coatings

The interfacial study of sol–gel-derived fluoridated hydroxyapatite coatings

2005 ◽  
Vol 198 (1-3) ◽  
pp. 242-246 ◽  
Author(s):  
Kui Cheng ◽  
Sam Zhang ◽  
Wenjian Weng ◽  
Xianting Zeng
Keyword(s):  
Sol Gel ◽  
Fluoridated Hydroxyapatite ◽  
Hydroxyapatite Coatings

Improvement of bioactivity with magnesium and fluorine ions incorporated hydroxyapatite coatings via sol–gel deposition on Ti6Al4V alloys

2009 ◽  
Vol 517 (17) ◽  
pp. 5347-5351 ◽  
Author(s):  
Yanli Cai ◽  
Sam Zhang ◽  
Xianting Zeng ◽  
Yongsheng Wang ◽  
Min Qian ◽  
...  
Keyword(s):  
Sol Gel ◽  
Hydroxyapatite Coatings ◽  
Fluorine Ions

In vitro behavior of fluoridated hydroxyapatite coatings in organic-containing simulated body fluid

2007 ◽  
Vol 27 (2) ◽  
pp. 244-250 ◽  
Author(s):  
Yongsheng Wang ◽  
Sam Zhang ◽  
Xianting Zeng ◽  
Kui Cheng ◽  
Min Qian ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Fluoridated Hydroxyapatite ◽  
Hydroxyapatite Coatings

Human Bone Derived Cell (HBDC) Behaviour of Sol-Gel Derived Carbonate Hydroxyapatite Coatings on Titanium Alloy Substrates

2005 ◽  
Vol 284-286 ◽  
pp. 541-544 ◽  
Author(s):  
Hala Zreiqat ◽  
R. Roest ◽  
Stella Valenzuela ◽  
Adriyan Milev ◽  
Besim Ben-Nissan
Keyword(s):  
Titanium Alloy ◽  
Surface Chemistry ◽  
Sol Gel ◽  
Surface Characteristics ◽  
Human Bone ◽  
Skeletal Tissue ◽  
Carbonate Hydroxyapatite ◽  
Hydroxyapatite Coatings ◽  
Coating Methods ◽  
Surface Chemistry Modification

Poor cell adhesion to orthopaedic and dental implants results in implant failure. Establishing and maintaining mature bone at the bone/device interface is critical to the long-term success of the prostheses. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of device and skeleton in the noncemented joint prosthesis. Previously we demonstrated that surface chemistry modification of bioceramics induced osteogenesis. In the present work, we investigate the effect of surface chemistry modification of titanium alloy (Ti-6Al-4V) with alkoxide-derived carbonate hydroxyapatite (CHAp) using sol-gel coating methods on human bone derived cell (HBDC)behaviour. Western blotting demonstrated that sol gel coating of Ti-6Al-4V with CHAp upregulated the expression of key signalling protein Shc isoforms (p46, p52, p66) and phosphorylated Erk1/2. CHAp-modification of Ti-6Al-4V is associated with signal transduction pathways involving the key signalling protein Shc and ERK1/2 which may lead to enhanced gene expression of extracellular matrix proteins at the skeletal tissue/device interface.

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