scholarly journals Nerve growth factor-immobilized polypyrrole: Bioactive electrically conducting polymer for enhanced neurite extension

2007 ◽  
Vol 81A (1) ◽  
pp. 135-149 ◽  
Author(s):  
Natalia Gomez ◽  
Christine E. Schmidt
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Conducting Polymer ◽  
Nerve Growth ◽  
Neurite Extension ◽  
Electrically Conducting

scholarly journals Nerve Growth Factor-Immobilized Electrically Conducting Fibrous Scaffolds for Potential Use in Neural Engineering Applications

2012 ◽  
Vol 11 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Jae Y. Lee ◽  
Chris A. Bashur ◽  
Craig A. Milroy ◽  
Leandro Forciniti ◽  
Aaron S. Goldstein ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neural Engineering ◽  
Engineering Applications ◽  
Nerve Growth ◽  
Electrically Conducting ◽  
Fibrous Scaffolds ◽  
Potential Use

scholarly journals Xray Irradiation Promotes Nerve Growth Factor-induced Neurite Extension in PC12 Cells

RADIOISOTOPES ◽  
2016 ◽  
Vol 65 (3) ◽  
pp. 137-143 ◽  
Author(s):  
Shinsuke Katoh ◽  
Junya Kobayashi ◽  
Tomonobu Umeda ◽  
Yoshiko Kobayashi ◽  
Nobuo Izumo ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Nerve Growth ◽  
Neurite Extension

A Laminin and Nerve Growth Factor-Laden Three-Dimensional Scaffold for Enhanced Neurite Extension

1999 ◽  
Vol 5 (4) ◽  
pp. 291-304 ◽  
Author(s):  
Xiaojun Yu ◽  
George P. Dillon ◽  
Ravi V. Bellamkonda
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Three Dimensional ◽  
Nerve Growth ◽  
Neurite Extension

scholarly journals Neurite Extension Occurs in the Absence of Regulated Exocytosis in PC12 Subclones

1999 ◽  
Vol 10 (9) ◽  
pp. 2919-2931 ◽  
Author(s):  
Chiara Leoni ◽  
Andrea Menegon ◽  
Fabio Benfenati ◽  
Daniela Toniolo ◽  
Maria Pennuto ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Growth Factor Receptor ◽  
Morphological Differentiation ◽  
Nerve Growth ◽  
Neurite Extension ◽  
Process Formation ◽  
Dense Core Granules ◽  
Activation Pathways

We have investigated the process leading to differentiation of PC12 cells. This process is known to include extension of neurites and changes in the expression of subsets of proteins involved in cytoskeletal rearrangements or in neurosecretion. To this aim, we have studied a PC12 clone (trk-PC12) stably transfected with the nerve growth factor receptor TrkA. These cells are able to undergo both spontaneous and neurotrophin-induced morphological differentiation. However, both undifferentiated and nerve growth factor-differentiated trk-PC12 cells appear to be completely defective in the expression of proteins of the secretory apparatus, including proteins of synaptic vesicles and large dense-core granules, neurotransmitter transporters, and neurotransmitter-synthesizing enzymes. These results indicate that neurite extension can occur independently of the presence of the neurosecretory machinery, including the proteins that constitute the fusion machine, suggesting the existence of differential activation pathways for the two processes during neuronal differentiation. These findings have been confirmed in independent clones obtained from PC12-27, a previously characterized PC12 variant clone globally incompetent for regulated secretion. In contrast, the integrity of the Rab cycle appears to be necessary for neurite extension, because antisense oligonucleotides against the neurospecific isoform of Rab-guanosine diphosphate-dissociation inhibitor significantly interfere with process formation.

Sign in / Sign up

Export Citation Format

Share Document