Microrough titanium surface affects biologic response in MG63 osteoblast-like cells

2006 ◽  
Vol 79A (4) ◽  
pp. 1023-1032 ◽  
Author(s):  
Myung-Joo Kim ◽  
Chang-Whe Kim ◽  
Young-Jun Lim ◽  
Seong-Joo Heo
Keyword(s):  
Titanium Surface ◽  
Biologic Response

scholarly journals The effect of strontium modified rough titanium surface on biologic response of MC3T3-E1 cells

2020 ◽  
Vol 39 (5) ◽  
pp. 808-814
Author(s):  
Huanhuan JIANG ◽  
Wenjuan ZHOU ◽  
Binchen WANG ◽  
Liqin TANG
Keyword(s):  
Titanium Surface ◽  
Biologic Response

Response to DDAVP in children with von Willebrand disease type 2

2009 ◽  
Vol 29 (02) ◽  
pp. 143-148 ◽  
Author(s):  
U. Budde ◽  
K. Beutel ◽  
W.-A. Hassenpflug ◽  
H. Hauch ◽  
T. Obser ◽  
...  
Keyword(s):  
Disease Type ◽  
Von Willebrand Disease ◽  
Molecular Defect ◽  
Variable Response ◽  
Functional Parameters ◽  
Functional Defect ◽  
Biologic Response ◽  
High Level ◽  
Von Willebrand

SummaryWe have prospectively evaluated the biologic response to desmopressin (DDAVP) in 28 children with type 2 von Willebrand disease (VWD) in correlation with the phenotype and the molecular defect of VWF. The diagnosis of VWD type 2 was mainly based on VWF functional parameters and/or an aberrant VWF multimer pattern. Seventeen different mutations were identified (6 of them novel). No response with respect to the functional parameters VWF:RCo and/or VWF:CB was seen in patients with severe abnormality of the VWF multimer pattern. One patient with VWD type 2A phenotype IIC Miami did not respond with respect to VWF:CB, but showed a good response of VWF:Ag and FVIII:C as expected. Interestingly he showed a persistently high level of VWF:Ag and FVIII:C up to 4 hours after DDAVP infusion. Patients with minor alterations of multimer structure and particular mutations responded well to DDAVP, whereas patients with normal multimer structure but a defect in platelet dependent functional parameters did not respond with VWF:RCo. Conclusion: Children with VWD type 2 show a variable response to desmopressin depending on the mutation that correlates with the functional defect and the presence or absence as well as the half-life of large VWF multimers. Our data emphasize the usefulness of DDAVP testing even in patients with VWD type 2, possibly with the exception of VWD type 2B.

Surface treatment with silver particles isles on Titanium cp: study of antimicrobial activity

2020 ◽  
Vol 9 (4) ◽  
pp. e27942662
Author(s):  
Patrícia Capellato ◽  
Cláudia Eliana Bruno Marino ◽  
Gilbert Silva ◽  
Lucas Victor Benjamim Vasconcelos ◽  
Rodrigo Perito Cardoso ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Surface Treatment ◽  
Titanium Surface ◽  
Silver Clusters ◽  
Silver Particles ◽  
Silver Deposition ◽  
Dispersed Particles ◽  
Significant Difference ◽  
Diffusion Assay ◽  
Antibacterial Potential

During the last decades, researchers have been growing the interest in surface treatment with an antimicrobial agent. Silver nanoparticles (AgNPs) are widely used in biomedical fields due to their potent antimicrobial activity. So, in this study was investigated silver particles (isles) coated on titanium surface for dental and orthopedic application. Silver particles coating process on titanium surface were performed via sputtering that is a plasma-assisted deposition technique with and titanium without treatment was applied as comparing standard. Plasma treatment parameters were optimized so that the result was not a thin film of Ag but dispersed particles of Ag on the Ti-cp surface. The alloy surfaces were investigated using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). In order to investigate antibacterial potential Staphylococcus aureus and Escherichia coli have been used at Agar diffusion assay. The results were analyzed by analysis of variance (ANOVA) in order to verify significant difference antimicrobial activity between samples that have shown no difference between the surfaces studied treatments. For silver deposition scattered particles (isles) over titanium surface for a 10-minute treatment, EDS revealed by silver clusters that the particles were not properly scattered onto surface, hence, the low effectiveness in antibacterial activity.

Reparação óssea no implante dental

2020 ◽  
Vol 12 (45) ◽  
pp. 63-66
Author(s):  
Halim Nagem Filho ◽  
Reinaldo Francisco Maia ◽  
Reinaldo Missaka ◽  
Nasser Hussein Fares
Keyword(s):  
Gene Expression ◽  
Titanium Surface ◽  
Close Contact ◽  
The Other ◽  
Main Function ◽  
Indirect Interaction ◽  
M2 Macrophages ◽  
Activated Macrophages ◽  
M1 Macrophages ◽  
High Production

The osseointegration is the stable and functional union between the bone and a titanium surface. A new bone can be found on the surface of the implant about 1 week after its installation; the bone remodeling begins between 6 and 12 weeks and continues throughout life. After the implant insertion, depending on the energy of the surface, the plasma fluid immediately adheres, in close contact with the surface, promoting the adsorption of proteins and inducing the indirect interaction of the cells with the material. Macrophages are cells found in the tissues and originated from bone marrow monocytes. The M1 macrophages orchestrate the phagocytic phase in the inflammatory region and also produce inflammatory cytokines involved with the chronic inflammation and the cleaning of the wound and damaged tissues from bacteria. On the other hand, alternative-activated macrophages (M2) are activated by IL-10, the immune complex. Its main function consists on regulating negatively the inflammation through the secretion of the immunosuppressant IL-10. The M2 macrophages present involvement with the immunosuppression, besides having a low capacity for presenting antigens and high production of cytokines; these can be further divided into M2a, M2b, and M2c, based on the gene expression profile.

In Vitro Immunodetection of Prothymosin Alpha in Normal and Pathological Conditions

2020 ◽  
Vol 27 (29) ◽  
pp. 4840-4854 ◽  
Author(s):  
Chrysoula-Evangelia Karachaliou ◽  
Hubert Kalbacher ◽  
Wolfgang Voelter ◽  
Ourania E. Tsitsilonis ◽  
Evangelia Livaniou
Keyword(s):  
Mammalian Cells ◽  
Therapeutic Potential ◽  
Prothymosin Alpha ◽  
Disease States ◽  
Leading Role ◽  
Tissue Extracts ◽  
Biologic Response ◽  
Health And Disease ◽  
Almost All

Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similar to molecules termed as “alarmins”. Antibodies and immunochemical techniques for ProTα have played a leading role in the investigation of the biological role of ProTα, several aspects of which still remain unknown and contributed to unraveling the diagnostic and therapeutic potential of the polypeptide. This review deals with the so far reported antibodies along with the related immunodetection methodology for ProTα (immunoassays as well as immunohistochemical, immunocytological, immunoblotting, and immunoprecipitation techniques) and its application to biological samples of interest (tissue extracts and sections, cells, cell lysates and cell culture supernatants, body fluids), in health and disease states. In this context, literature information is critically discussed, and some concluding remarks are presented.

Effects of Ar ion irradiation in an ICP discharge on the titanium surface topology

2020 ◽  
Vol 527 ◽  
pp. 146902 ◽  
Author(s):  
Maksim M. Kharkov ◽  
Andrey V. Kaziev ◽  
Daria V. Danilyuk ◽  
Margarita S. Kukushkina ◽  
Nikolay A. Chernyh ◽  
...  
Keyword(s):  
Titanium Surface ◽  
Ion Irradiation ◽  
Surface Topology

Mechanism of anti-proteins adsorption behavior on superhydrophobic titanium surface

2021 ◽  
pp. 127421
Author(s):  
Jing Zhang ◽  
Guiling Li ◽  
Jia Man ◽  
Yifei Qu ◽  
Ziyu Guo ◽  
...  
Keyword(s):  
Titanium Surface ◽  
Adsorption Behavior

scholarly journals Photo-activated titanium surface confers time dependent bactericidal activity towards Gram positive and negative bacteria

2021 ◽  
pp. 111940
Author(s):  
Fei Pan ◽  
Stefanie Altenried ◽  
Flavia Zuber ◽  
Raphael S. Wagner ◽  
Yen-Hsun Su ◽  
...  
Keyword(s):  
Bactericidal Activity ◽  
Titanium Surface ◽  
Time Dependent ◽  
Gram Positive
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