Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: Synthesis,in vitro assessment, andin vivo evaluation

2006 ◽  
Vol 77A (4) ◽  
pp. 726-735 ◽  
Author(s):  
Liliana Verestiuc ◽  
Oana Nastasescu ◽  
Eugen Barbu ◽  
Indrajeetsinh Sarvaiya ◽  
Keith L. Green ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Networks ◽  
Ocular Drug Delivery ◽  
Hybrid Polymer ◽  
In Vitro Assessment

scholarly journals Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Lígia N. M. Ribeiro ◽  
Ana C. S. Alcântara ◽  
Gustavo H. Rodrigues da Silva ◽  
Michelle Franz-Montan ◽  
Silvia V. G. Nista ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Toxicity ◽  
Drug Delivery Systems ◽  
Hybrid Polymer ◽  
Future Perspectives ◽  
Sustained Drug Release ◽  
Physicochemical Stability ◽  
Traditional Drug

The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

Preparation and in vitro assessment of wet-spun gemcitabine-loaded polymeric fibers: Towards localized drug delivery for the treatment of pancreatic cancer

Pancreatology ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. 795-804 ◽  
Author(s):  
Samantha J. Wade ◽  
Amanda Zuzic ◽  
Javad Foroughi ◽  
Sepehr Talebian ◽  
Morteza Aghmesheh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Polymeric Fibers ◽  
In Vitro Assessment ◽  
Localized Drug Delivery

In vitro assessment of bioadhesion for periodontal and buccal drug delivery

Biomaterials ◽  
1995 ◽  
Vol 16 (8) ◽  
pp. 617-624 ◽  
Author(s):  
Ian G. Needleman ◽  
Frederick C. Smales
Keyword(s):  
Drug Delivery ◽  
Buccal Drug Delivery ◽  
In Vitro Assessment

Toward Drug Delivery into the Brain: Synthesis, Characterization, and Preliminary In Vitro Assessment of Alkylglyceryl-Functionalized Chitosan Nanoparticles

2010 ◽  
Vol 11 (11) ◽  
pp. 2880-2889 ◽  
Author(s):  
Éva Molnár ◽  
Eugen Barbu ◽  
Chun-Fu Lien ◽  
Dariusz C. Górecki ◽  
John Tsibouklis
Keyword(s):  
Drug Delivery ◽  
Chitosan Nanoparticles ◽  
In Vitro Assessment ◽  
The Brain

scholarly journals New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations

2021 ◽  
Vol Volume 15 ◽  
pp. 351-360
Author(s):  
Tivadar Bíró ◽  
Alexandra Bocsik ◽  
Bisera Jurišić Dukovski ◽  
Ilona Gróf ◽  
Jasmina Lovrić ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
Ocular Drug Delivery ◽  
New Approach
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