The role of astragaloside in regeneration of the peripheral nerve system

2006 ◽  
Vol 76A (3) ◽  
pp. 463-469 ◽  
Author(s):  
Chun-Yuan Cheng ◽  
Chun-Hsu Yao ◽  
Bai-Shuan Liu ◽  
Chien-Ju Liu ◽  
Guan-Wei Chen ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerve System ◽  
Nerve System

Emerging role of MicroRNAs in peripheral nerve system

Life Sciences ◽  
2018 ◽  
Vol 207 ◽  
pp. 227-233 ◽  
Author(s):  
Jiayi Zhang ◽  
Yang Liu ◽  
Laijin Lu
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerve System ◽  
Nerve System

Physiology of the peripheral nerve system

2003 ◽  
Vol 21 (10) ◽  
pp. 264a-264e
Author(s):  
Kannan Nithi
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerve System ◽  
Nerve System

Central and Peripheral Nerve System Tumors

2011 ◽  
pp. 119-135
Author(s):  
Hueizhi Wu ◽  
Conrad Schuerch ◽  
Douglas C. Miller
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerve System ◽  
Nerve System

scholarly journals Acetylcholinesterase and Butyrylcholinesterase – Important Enzymes of Human Body

2004 ◽  
Vol 47 (4) ◽  
pp. 215-228 ◽  
Author(s):  
Jiří Patočka ◽  
Kamil Kuča ◽  
Daniel Jun
Keyword(s):  
Reaction Mechanism ◽  
Peripheral Nerve ◽  
Human Body ◽  
Physiological Function ◽  
Human Tissues ◽  
Serine Hydrolases ◽  
Chemical Reaction Mechanism ◽  
Cholinesterase Activities ◽  
Peripheral Nerve System ◽  
Nerve System

The serine hydrolases and proteases are a ubiquitous group of enzymes that is fundamental to many critical lifefunctions. Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown. Acetylcholinesterase is one of the crucial enzymes in the central and peripheral nerve system. Organophosphates and carbamates are potent inhibitors of serine hydrolases and well suited probes for investigating the chemical reaction mechanism of the inhibition. Understanding the enzyme’s chemistry is essential in preventing and/or treating organophosphate and carbamate poisoning as well as designing new medicaments for cholinergic-related diseases like as Alzheimer’s disease.

TPP ionically cross-linked chitosan/PLGA microspheres for the delivery of NGF for peripheral nerve system repair

2021 ◽  
Vol 258 ◽  
pp. 117684
Author(s):  
Wen Zeng ◽  
Hua Hui ◽  
Zhongyang Liu ◽  
Zhen Chang ◽  
Mingbo Wang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Plga Microspheres ◽  
Peripheral Nerve System ◽  
Nerve System

scholarly journals Correction: Promoting Myelination in an In Vitro Mouse Model of the Peripheral Nerve System: The Effect of Wine Ingredients

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
Author(s):  
Mark Stettner ◽  
Kathleen Wolffram ◽  
Anne K. Mausberg ◽  
Philipp Albrecht ◽  
Angelika Derksen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Peripheral Nerve ◽  
Peripheral Nerve System ◽  
Nerve System

Loss‐of‐function of EBP50 is a new cause of hereditary peripheral neuropathy: EBP50 functions in peripheral nerve system

Glia ◽  
2020 ◽  
Vol 68 (9) ◽  
pp. 1794-1809 ◽  
Author(s):  
Gyun Jee Song ◽  
Deepak Prasad Gupta ◽  
Md Habibur Rahman ◽  
Hwan Tae Park ◽  
Imad Al Ghouleh ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Peripheral Nerve ◽  
Loss Of Function ◽  
Peripheral Nerve System ◽  
Hereditary Peripheral Neuropathy ◽  
Nerve System

scholarly journals Obestatin signaling controls Schwann cells and axonal transport to counteract neuromuscular synaptic loss in skeletal muscle

2020 ◽  
Author(s):  
Jesus P Camiña ◽  
Agustín Sánchez-Temprano ◽  
Saúl Leal-López ◽  
Jessica González-Sánchez ◽  
Carlos S. Mosteiro ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Nerve Repair ◽  
Axon Growth ◽  
Neuromuscular Synapses ◽  
Axonal Regrowth ◽  
Peripheral Nerve System ◽  
Nerve System

Abstract Background. Injuries to the peripheral nerve system are common conditions, with broad spectrum of symptoms depending on the impaired nerves and severity of damage. Although peripheral nervous system retains a remarkable ability for regeneration, it is estimated that less than ten percent of patients fully recover function after nerve injury and the available treatments remain suboptimal. Here, we identify a role for the obestatin/GPR39 system in the regulation of the Schwann cell plasticity as well as in the preservation of neuromuscular synapses in the course of nerve repair. Methods. Utilizing a compression model of sciatic nerve injury, axonotmesis, we assessed the obestatin-related regenerative response in the peripheral nerve system. The role of the obestatin/GPR39 system was further evaluated on immortalized rat Schwann cells, IFRS1, and the model of neuronal differentiation, PC12 cells. The interactions between SCs and neurons was evaluated using a co-culture system that combine the SC cell line IFRS1 and the NGF-primed PC12. Results. Obestatin signaling directs proliferation and migration of Schwann cells that sustain axonal regrowth and later remyelinate regenerated axons. We provide evidence supporting the preservation of skeletal muscle by the maintenance of neuromuscular synapses through the axonal regulation of calpain-calpastatin proteolytic system. This encompasses the control of skeletal muscle homeostasis by regulation of the ubiquitin proteasome system and the autophagy machinery. Conclusions. These results provide important insights into how the obestatin/GPR39 system promotes nerve repair through integration of multiple molecular cues of neuron-Schwann cells crosstalk aimed to promote axon growth and guide axons back to their targets.

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