Degradation and cell culture studies on block copolymers prepared by ring opening polymerization of ?-caprolactone in the presence of poly(ethylene glycol)

2004 ◽  
Vol 69A (3) ◽  
pp. 417-427 ◽  
Author(s):  
Ming-Hsi Huang ◽  
Suming Li ◽  
Dietmar Werner Hutmacher ◽  
Jan-Thorsten Schantz ◽  
Charles Alfred Vacanti ◽  
...  
Keyword(s):  
Cell Culture ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Culture Studies ◽  
Poly Ethylene

Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)

2020 ◽  
Vol 04 ◽  
Author(s):  
Manu Singhai ◽  
Sankha Bhattacharya
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Protein Delivery ◽  
Ring Opening ◽  
Biomedical Applications ◽  
High Vacuum ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Biologically Relevant ◽  
Poly Ethylene

Abstract:: Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by wesley and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

2015 ◽  
Vol 749 ◽  
pp. 433-436
Author(s):  
Chih Kuang Chen ◽  
Wen Jen Lin ◽  
Guan You Chen ◽  
Yu Te Lin ◽  
Rong Siou Jhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Chain Length ◽  
Self Assembly ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Material Chemistry ◽  
Poly Ethylene

With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer drug delivery. In this study, a newly developed polymerization technique termed as “sequential ring-opening polymerization (SROP)“ was used to synthesize poly (ethylene glycol)-block-polylactide-block-polylactide (PEG-PLA-PLAs). Utilizing the features of SROP, well-controlled chain length of two different PLA blocks by using PEG as initiator can be achieved. Two types of PEG-PLA-PLAs, PEG-PLA11-PLA11 and PEG-PLA18-PLA18, were successfully synthesized and characterized. Having amphiphilic properties, PEG-PLA-PLAs were used to form micelles through self-assembly. The effects of PLA length on the resultant micelles were thoroughly investigated.

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