Modulation of bone ingrowth and tissue differentiation by local infusion of interleukin-10 in the presence of ultra-high molecular weight polyethylene (UHMWPE) wear particles

2003 ◽  
Vol 65A (1) ◽  
pp. 43-50 ◽  
Author(s):  
Stuart Goodman ◽  
Michael Trindade ◽  
Ting Ma ◽  
Mel Lee ◽  
Neal Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Bone Ingrowth ◽  
Interleukin 10 ◽  
Tissue Differentiation ◽  
Wear Particles ◽  
Uhmwpe Wear ◽  
Uhmwpe Wear Particles ◽  
Ultra High Molecular Weight

Effect of Lubricant Protein Concentration on the Wear of Ultra-High Molecular Weight Polyethylene Sliding Against a CoCr Counterface

2003 ◽  
Vol 125 (3) ◽  
pp. 638-642 ◽  
Author(s):  
Vesa Saikko
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Protein Concentration ◽  
Calf Serum ◽  
Wear Testing ◽  
Wear Factor ◽  
Prosthetic Joints ◽  
Uhmwpe Wear ◽  
Pin On Disk ◽  
Ultra High Molecular Weight

In the wear testing of prosthetic joints, the optimal lubricant protein concentration is disputed. The effect of protein concentration of calf serum based lubricant on the wear of ultra-high molecular weight polyethylene against CoCr was studied with a 12-station, circularly translating pin-on-disk device. The wear factor first steeply increased with increasing concentration, reached a peak at 10–20 mg/ml, and then slowly decreased. Below 20 mg/ml, the wear mechanisms were not entirely representative of clinical wear. Above this value, the morphology of the UHMWPE wear surface resembled that of retrieved cups. The results indicated that the concentration should not be below 20 mg/ml. The scope of this recommendation is discussed.

Ultra-High Molecular Weight Polyethylene Wear Debris Generated in Vivo and in Laboratory Tests; the Influence of Counterface Roughness

1996 ◽  
Vol 210 (1) ◽  
pp. 3-10 ◽  
Author(s):  
J L Hailey ◽  
E Ingham ◽  
M Stone ◽  
B M Wroblewski ◽  
J Fisher
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Wear Debris ◽  
Laboratory Tests ◽  
Polyethylene Wear ◽  
Uhmwpe Wear ◽  
Major Variable ◽  
Ultra High Molecular Weight ◽  
Counterface Roughness

The objective of this study was to investigate the effect of counterface roughness and lubricant on the morphology of ultra-high molecular weight polyethylene (UHMWPE) wear debris generated in laboratory wear tests, and to compare this with debris isolated from explanted tissue. Laboratory tests used UHMWPE pins sliding against stainless steel counterfaces. Both water and serum lubricants were used in conjunction with rough and smooth counterfaces. The lubricants and tissue from revision hip surgery were processed to digest the proteins and permit filtration. This involved denaturing the proteins with potassium hydroxide (KOH), sedimentation of any remaining proteins, and further digestion of these proteins with chromic acid. All fractions were then passed through a 0.2 μm membrane, and the debris examined using scanning electron microscopy. The laboratory studies showed that the major variable influencing debris morphology was counterface roughness. The rougher counter-faces produced larger numbers of smaller particles, with a size range extending below 1 μm. For smooth counterfaces there were fewer of these small particles, and evidence of larger platelets, greater than 10 μm in diameter. Analysis of the debris from explanted tissues showed a wide variation in the particle size distribution, ranging from below 1 μm up to several millimetres in size. Of major clinical significance in relation to osteolysis and loosening is roughening of the femoral components, which may lead to greater numbers of the sub-micron-sized particles.

Tribological property and cell toxicity of wear particles of ultra high molecular weight polyethylene

2004 ◽  
Vol 2004.10 (0) ◽  
pp. 147-148
Author(s):  
Hiromichi FUJIE ◽  
Isamu SEKIGUCHI ◽  
Yu KURATA ◽  
Kenichi TAKEMOTO ◽  
Masashi MORITA
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Tribological Property ◽  
Wear Particles ◽  
Cell Toxicity ◽  
Ultra High Molecular Weight

scholarly journals Correlating subjective and objective descriptors of ultra high molecular weight wear particles from total joint prostheses

Biomaterials ◽  
2006 ◽  
Vol 27 (5) ◽  
pp. 752-757 ◽  
Author(s):  
Brian T. McMullin ◽  
Ming-Ying Leung ◽  
Arun S. Shanbhag ◽  
Donald McNulty ◽  
Jay D. Mabrey ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Wear Particles ◽  
Joint Prostheses ◽  
Ultra High Molecular Weight
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