Silicone breast implants: The role of immune system on capsular contracture formation

1995 ◽  
Vol 29 (2) ◽  
pp. 197-202 ◽  
Author(s):  
Donatella Granchi ◽  
Daniela Cavedagna ◽  
Gabriela Ciapetti ◽  
Susanna Stea ◽  
Patrizia Schiavon ◽  
...  
Keyword(s):  
Immune System ◽  
Capsular Contracture ◽  
Breast Implants ◽  
Silicone Breast Implants ◽  
Contracture Formation

The effect of late infection and antibiotic treatment on capsular contracture in silicone breast implants: A rat model

2016 ◽  
Vol 69 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Katherine E. Miller ◽  
Bernardo Hontanilla ◽  
Alvaro Cabello ◽  
Diego Marre ◽  
Leticia Armendariz ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Rat Model ◽  
Capsular Contracture ◽  
Breast Implants ◽  
Late Infection ◽  
Silicone Breast Implants

scholarly journals Research Related to Capsular Contracture after Breast Augmentation for Cosmetic or Reconstructive Purposes

2019 ◽  
Vol 70 (5) ◽  
pp. 1619-1624
Author(s):  
Silviu Adrian Marinescu ◽  
Dan Mircea Enescu ◽  
Catalin Gheorghe Bejinariu ◽  
Carmen Giuglea
Keyword(s):  
Breast Augmentation ◽  
Cell Lymphoma ◽  
Breast Implant ◽  
Capsular Contracture ◽  
Breast Implants ◽  
Large Cell ◽  
Upward Trend ◽  
Silicone Breast Implants ◽  
Number Of Patients ◽  
Alloplastic Breast Reconstruction

The upward trend of patients opting for elective breast augmentation, as well as the large number of patients benefiting from alloplastic breast reconstruction, require further studies on the safety profile of these techniques. Without any doubt, the incidence of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) has drawn attention to the possible unknown complications characteristic of these procedures, creating the context of further studies devoted to this issue. The present research examines the capsular contracture rate on a group of 253 patients between 2015 and 2019, also proposing a scoring system based on the integration of the main diagnostic criteria related to the capsular contracture. The results of the literature review indicate that a lower incidence of capsular contracture could be achieved by using the newest techniques in the field involving the application of chemical substances on the surface of the latest generation of silicone breast implants.

scholarly journals Classical Examples of the Concept of the ASIA Syndrome

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1436
Author(s):  
Vânia Borba ◽  
Anna Malkova ◽  
Natalia Basantsova ◽  
Gilad Halpert ◽  
Laura Andreoli ◽  
...  
Keyword(s):  
Immune System ◽  
Clinical Manifestations ◽  
Breast Implants ◽  
Undifferentiated Connective Tissue Disease ◽  
Ptpn22 Gene ◽  
Silicone Breast Implants ◽  
Immune Mediated ◽  
Asia Syndrome ◽  
Skin Biopsies ◽  
Inflammatory Syndrome

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous clinical manifestations and severity. In this review, five enigmatic conditions, including sarcoidosis, Sjögren’s syndrome, undifferentiated connective tissue disease, silicone implant incompatibility syndrome (SIIS), and immune-related adverse events (irAEs), are defined as classical examples of ASIA. Certainly, these disorders have been described after an adjuvant stimulus (silicone implantation, drugs, infections, metals, vaccines, etc.) among genetically predisposed individuals (mainly the HLA-DRB1 and PTPN22 gene), which induce an hyperstimulation of the immune system resulting in the production of autoantibodies, eventually leading to the development of autoimmune diseases. Circulating autonomic autoantibodies in the sera of patients with silicone breast implants, as well as anatomopathological aspects of small fiber neuropathy in their skin biopsies have been recently described. To our knowledge, these novel insights serve as a common explanation to the non-specific clinical manifestations reported in patients with ASIA, leading to the redefinition of the ASIA syndrome diagnostic criteria.

scholarly journals Capsular Contracture In Silicone Breast Implants: Insights From Rat Models

2016 ◽  
Vol 88 (3) ◽  
pp. 1459-1470 ◽  
Author(s):  
VILBERTO J. VIEIRA ◽  
ARMANDO D'ACAMPORA ◽  
FERNANDA S. NEVES ◽  
PAULO R. MENDES ◽  
ZULMAR A. DE VASCONCELLOS ◽  
...  
Keyword(s):  
Capsular Contracture ◽  
Breast Implants ◽  
Silicone Breast Implants ◽  
Rat Models

Stealthy role of size-driven stresses in biomechanics of breast implants capsular contracture

2016 ◽  
Vol 64 ◽  
pp. 199-208 ◽  
Author(s):  
Massimiliano Fraldi ◽  
Luca Esposito ◽  
Arsenio Cutolo ◽  
Angelo Rosario Carotenuto ◽  
Ciro Adamo ◽  
...  
Keyword(s):  
Capsular Contracture ◽  
Breast Implants

scholarly journals Poly Implant Prothèse silicone breast implants: implant dynamics and capsular contracture

2018 ◽  
Vol 41 (5) ◽  
pp. 563-570 ◽  
Author(s):  
Y. Bachour ◽  
Z. C. M. Heinze ◽  
T. S. Dormaar ◽  
W. G. van Selms ◽  
M. J. P. F. Ritt ◽  
...  
Keyword(s):  
Capsular Contracture ◽  
Breast Implants ◽  
Silicone Breast Implants

scholarly journals Five-Year Retrospective Analysis of Eurosilicone’s Silicone Gel–Filled Breast Implants

2019 ◽  
Vol 1 (3) ◽  
Author(s):  
Maurizio Saturno ◽  
Sharon Stewart ◽  
Erin Bell ◽  
Emanuela Esposito
Keyword(s):  
Clinical Study ◽  
Breast Augmentation ◽  
Capsular Contracture ◽  
Breast Implants ◽  
Magnetic Resonance Images ◽  
Implant Removal ◽  
Actual Rate ◽  
Silicone Breast Implants ◽  
Silicone Gel ◽  
Retrospective Clinical Study

Abstract Background Silicone breast implants have been widely used for breast augmentation and reconstruction. During this time, silicone breast implants have undergone several modifications to improve their safety, quality, and clinical performance. Complications such as reoperation, capsular contracture, and rupture are risks often associated with breast implants. Objectives The authors conducted a retrospective study to analyze and report complication rates associated with Eurosilicone’s (Eurosilicone S.A.S, Apt, Cedex, France) silicone gel–filled breast implants over a period of 5 years. Methods In this retrospective clinical study, 2151 women who underwent either breast augmentation or breast reconstruction with Eurosilicone breast implants were diagnosed. Data on early and late complications including implant removal (explantation/exchange), capsular contracture, and rupture were collected using questionnaires, completed by 39 surgeons across Italy. Results Of the 2151, only 60 patients (2.78%) required implant removal. Twenty-five patients experienced capsular contracture (Baker Grade III/IV), giving an actual rate of 1.2%. The actual rate of implant rupture confirmed by breast magnetic resonance images was 0.18% (4 implants). Six patients (0.27%) were diagnosed with breast cancer following breast augmentation, and local complications including hematoma (1 patient) and seroma (2 patients) were experienced. Conclusions This retrospective clinical study involving Eurosilicone’s round and anatomical textured silicone gel–filled mammary implants demonstrates an excellent safety profile through 5 years. Level of Evidence: 2

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