In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA

2001 ◽  
Vol 59 (1) ◽  
pp. 144-151 ◽  
Author(s):  
Jeong-Sook Park ◽  
Yu-Kyoung Oh ◽  
Ho Yoon ◽  
Jung Mogg Kim ◽  
Chong-Kook Kim
Keyword(s):  
Plasmid Dna ◽  
Intranasal Delivery ◽  
Mucoadhesive Polymer ◽  
In Situ Gelling

scholarly journals Intranasal delivery of a bivalent norovirus vaccine formulated in an in situ gelling dry powder

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177310 ◽  
Author(s):  
Jordan P. Ball ◽  
Michael J. Springer ◽  
Yawei Ni ◽  
Isaac Finger-Baker ◽  
Juan Martinez ◽  
...  
Keyword(s):  
Intranasal Delivery ◽  
Dry Powder ◽  
In Situ Gelling

scholarly journals Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine

Vaccine ◽  
2011 ◽  
Vol 29 (32) ◽  
pp. 5221-5231 ◽  
Author(s):  
Lissette S. Velasquez ◽  
Samantha Shira ◽  
Alice N. Berta ◽  
Jacquelyn Kilbourne ◽  
Babu M. Medi ◽  
...  
Keyword(s):  
Intranasal Delivery ◽  
Norwalk Virus ◽  
Dry Powder ◽  
Virus Like Particles ◽  
In Situ Gelling

scholarly journals Liposome in situ gelling system: Novel carrier based vaccine adjuvant for intranasal delivery of recombinant protein vaccine

2009 ◽  
Vol 1 (1) ◽  
pp. 148-163 ◽  
Author(s):  
Shailja Tiwari ◽  
Amit K. Goyal ◽  
Neeraj Mishra ◽  
Bhuvaneshwar Vaidya ◽  
Abhinav Mehta ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Vaccine Adjuvant ◽  
Intranasal Delivery ◽  
Protein Vaccine ◽  
Recombinant Protein Vaccine ◽  
In Situ Gelling

Novel Formulation Development and Evaluation of Nanoparticles Based in Situ Gelling System for The Ophthalmic Delivery of Ciprofloxacin Hydrochloride

2015 ◽  
Vol 5 (4) ◽  
Author(s):  
Kranti Singh ◽  
Surajpal Verma ◽  
Shyam Prasad ◽  
Indu Bala
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Drug Loading ◽  
In Vitro Release ◽  
Formulation Development ◽  
Ciprofloxacin Hydrochloride ◽  
Potential Value ◽  
The Mean ◽  
In Situ Gelling

Ciprofloxacin hydrochloride loaded Eudragit RS100 nanoparticles were prepared by using w/o/w emulsification (multiple emulsification) solvent evaporation followed by drying of nanoparticles at 50°C. The nanoparticles were further incorporated into the pH-triggered in situ gel forming system which was prepared using Carbopol 940 in combination with HPMC as viscosifying agent. The developed nanoparticles was evaluated for particle size, zeta potential value and loading efficiency; nanoparticle incorporated in situ gelling system was evaluated for pH, clarity, gelling strength, rheological studies, in-vitro release studies and ex-vivo precorneal permeation studies. The nanopaticle showed the mean particle size varying between 263.5nm - 325.9 nm with the mean zeta potential value of -5.91 mV to -8.13 mV and drug loading capacity varied individually between 72.50% to 98.70% w/w. The formulation was clear with no suspended particles, showed good gelling properties. The gelling was quick and remained for longer time period. The developed formulation was therapeutically efficacious, stable and non-irritant. It provided the sustained release of drug over a period of 8-10 hours.

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