scholarly journals Simultaneous multi‐spectral, single‐photon fluorescence imaging using a plasmonic colour filter array

2021 ◽  
Author(s):  
Peter W. R. Connolly ◽  
Jessica Valli ◽  
Yash D. Shah ◽  
Yoann Altmann ◽  
James Grant ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Single Photon ◽  
Colour Filter ◽  
Filter Array ◽  
Photon Fluorescence

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

scholarly journals Low-Light Photodetectors for Fluorescence Microscopy

2021 ◽  
Vol 11 (6) ◽  
pp. 2773
Author(s):  
Hiroaki Yokota ◽  
Atsuhito Fukasawa ◽  
Minako Hirano ◽  
Toru Ide
Keyword(s):  
Fluorescence Microscopy ◽  
Fluorescence Imaging ◽  
Single Molecule ◽  
Science Studies ◽  
Single Photon ◽  
Laser Scanning Microscopy ◽  
Oxide Semiconductor ◽  
Wide Field ◽  
Single Molecule Fluorescence ◽  
Low Light

Over the years, fluorescence microscopy has evolved and has become a necessary element of life science studies. Microscopy has elucidated biological processes in live cells and organisms, and also enabled tracking of biomolecules in real time. Development of highly sensitive photodetectors and light sources, in addition to the evolution of various illumination methods and fluorophores, has helped microscopy acquire single-molecule fluorescence sensitivity, enabling single-molecule fluorescence imaging and detection. Low-light photodetectors used in microscopy are classified into two categories: point photodetectors and wide-field photodetectors. Although point photodetectors, notably photomultiplier tubes (PMTs), have been commonly used in laser scanning microscopy (LSM) with a confocal illumination setup, wide-field photodetectors, such as electron-multiplying charge-coupled devices (EMCCDs) and scientific complementary metal-oxide-semiconductor (sCMOS) cameras have been used in fluorescence imaging. This review focuses on the former low-light point photodetectors and presents their fluorescence microscopy applications and recent progress. These photodetectors include conventional PMTs, single photon avalanche diodes (SPADs), hybrid photodetectors (HPDs), in addition to newly emerging photodetectors, such as silicon photomultipliers (SiPMs) (also known as multi-pixel photon counters (MPPCs)) and superconducting nanowire single photon detectors (SSPDs). In particular, this review shows distinctive features of HPD and application of HPD to wide-field single-molecule fluorescence detection.

Enhanced Two-Photon Fluorescence Imaging and Therapy of Cancer Cells via Gold@Bridged Silsesquioxane Nanoparticles

Small ◽  
2014 ◽  
Vol 11 (3) ◽  
pp. 295-299 ◽  
Author(s):  
Jonas Croissant ◽  
Marie Maynadier ◽  
Olivier Mongin ◽  
Vincent Hugues ◽  
Mireille Blanchard-Desce ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Two Photon ◽  
Bridged Silsesquioxane ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

A lysosome-targeted near-infrared photosensitizer for photodynamic therapy and two-photon fluorescence imaging

2021 ◽  
Author(s):  
Yinuo Tu ◽  
Weikang Xia ◽  
Xu Wu ◽  
Lei Wang
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Organelle-targeted two-photon near-infrared photosensitizers are highly desirable for photodynamic therapy (PDT) of cancer. Herein, in this contribution, we have developed a 2-dicyanomethylenethiazole based D-π-A structured near-infrared photosensitizer (TTR). TTR depicts...

Facile Synthesis of Efficient Luminogens with AIE Features for Three‐Photon Fluorescence Imaging of the Brain through the Intact Skull

2020 ◽  
Vol 32 (23) ◽  
pp. 2000364 ◽  
Author(s):  
Wei Qin ◽  
Nuernisha Alifu ◽  
Jacky W. Y. Lam ◽  
Yuhan Cui ◽  
Huifang Su ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Facile Synthesis ◽  
Photon Fluorescence ◽  
The Brain
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