scholarly journals Characterizing thrombus with multiple red blood cell compositions by optical coherence tomography attenuation coefficient

2020 ◽  
Author(s):  
Hsiao‐Chuan Liu ◽  
Mehdi Abbasi ◽  
Yong Hong Ding ◽  
Eric C. Polley ◽  
Seán Fitzgerald ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Blood Cell ◽  
Attenuation Coefficient ◽  
Red Blood Cell ◽  
Optical Coherence

scholarly journals Multiple-Capillary Measurement of RBC Speed, Flux, and Density with Optical Coherence Tomography

2013 ◽  
Vol 33 (11) ◽  
pp. 1707-1710 ◽  
Author(s):  
Jonghwan Lee ◽  
Weicheng Wu ◽  
Frederic Lesage ◽  
David A Boas
Keyword(s):  
Optical Coherence Tomography ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Linear Density ◽  
Flow Dynamics ◽  
Optical Coherence ◽  
Microvascular Flow ◽  
Different Depths

As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, we demonstrate the ability to quantify RBC speed, flux, and linear density. This technique will provide a means to monitor microvascular flow dynamics over many capillaries at different depths at the same time.

scholarly journals Capillary red blood cell velocimetry by phase-resolved optical coherence tomography

2017 ◽  
Vol 42 (19) ◽  
pp. 3976 ◽  
Author(s):  
Jianbo Tang ◽  
Sefik Evren Erdener ◽  
Buyin Fu ◽  
David A. Boas
Keyword(s):  
Optical Coherence Tomography ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Optical Coherence

Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography

2021 ◽  
Author(s):  
Marino de Jesus Maciel ◽  
Hugo M Pereira ◽  
Sara Pimenta ◽  
Alice Miranda ◽  
Eduardo Jorge Nunes-Pereira ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Attenuation Coefficient ◽  
Light Attenuation ◽  
Biological Tissues ◽  
Mammary Glands ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Subjective Analysis ◽  
Coefficient Estimation ◽  
Cross Sectional Imaging

Abstract Optical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary mouse glands with the OCT attenuation coefficient. Using several OCT images of normal and tumor mammary mouse glands (n=26), a statistical analysis was performed. The attenuation coefficient was calculated in depth, considering a slope of 0.5 mm. The normal glands present a median attenuation coefficient of 0.403 mm-1, comparatively to 0.561 mm-1 obtained for tumor mammary glands. This translates in an attenuation coefficient approximately 39 % higher for tumor mammary glands when compared to normal mammary glands. The OCT attenuation coefficient estimation eliminates the subjective analysis provided by direct visualization of the OCT images.

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