Optimal imaging windows of indocyanine green‐assisted near‐infrared dental imaging with rat model and its comparison to X‐ray imaging

2020 ◽  
Vol 13 (6) ◽  
Author(s):  
Zhongqiang Li ◽  
Thomas Hartzler ◽  
Alexandra Ramos ◽  
Michelle L. Osborn ◽  
Yanping Li ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Rat Model ◽  
Near Infrared ◽  
X Ray ◽  
Dental Imaging ◽  
X Ray Imaging ◽  
Optimal Imaging

Indocyanine green–assisted dental imaging in the first and second near‐infrared windows as compared with X‐ray imaging

2019 ◽  
Vol 1448 (1) ◽  
pp. 42-51 ◽  
Author(s):  
Zhongqiang Li ◽  
Waleed Zaid ◽  
Thomas Hartzler ◽  
Alexandra Ramos ◽  
Michelle L. Osborn ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
X Ray ◽  
Dental Imaging ◽  
X Ray Imaging

scholarly journals Long-term NIR variability in the UKIDSS Ultra Deep Survey: a new probe of AGN activity at high redshift

2020 ◽  
Vol 493 (2) ◽  
pp. 3026-3035 ◽  
Author(s):  
E Elmer ◽  
O Almaini ◽  
M Merrifield ◽  
W G Hartley ◽  
D T Maltby ◽  
...  
Keyword(s):  
Near Infrared ◽  
High Redshift ◽  
Galactic Nuclei ◽  
Host Galaxies ◽  
X Ray ◽  
X Ray Imaging ◽  
Sky Survey ◽  
Deep Survey ◽  
Stellar Masses

ABSTRACT We present the first attempt to select active galactic nuclei (AGN) using long-term near-infrared (NIR) variability. By analysing the K-band light curves of all the galaxies in the UKIRT Infrared Deep Sky Survey (UKIDSS) Ultra Deep Survey, the deepest NIR survey over ∼1 deg2, we have isolated 393 variable AGN candidates. A comparison to other selection techniques shows that only half of the variable sources are also selected using either deep Chandra X-ray imaging or Infrared Array Camera (IRAC) colour selection, suggesting that using NIR variability can locate AGN that are missed by more standard selection techniques. In particular, we find that long-term NIR variability identifies AGN at low luminosities and in host galaxies with low stellar masses, many of which appear relatively X-ray quiet.

scholarly journals Intraoperative Near-infrared Fluorescence Imaging with Novel Indocyanine Green-Loaded Nanocarrier for Spinal Metastasis: A Preliminary Animal Study

2012 ◽  
Vol 6 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Toru Funayama ◽  
Masataka Sakane ◽  
Tetsuya Abe ◽  
Isao Hara ◽  
Eiichi Ozeki ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Rat Model ◽  
Near Infrared ◽  
Imaging Modality ◽  
Intraoperative Imaging ◽  
Spinal Metastasis ◽  
Vena Cava ◽  
Nir Fluorescence

Marginal resection during resection of a spinal metastasis is frequently difficult because of the presence of important tissues such as the aorta, vena cava, and dura mater, including the spinal cord adjacent to the vertebral body. Thus, there is an urgent need for novel intraoperative imaging modalities with the ability to clearly identify bone metastasis. We have proposed a novel nanocarrier loaded with indocyanine green (ICG) (ICG-lactosome) with tumor selectivity attributable to its enhanced permeation and retention (EPR) effect. We studied its feasibility in intraoperative near-infrared (NIR) fluorescence diagnosis with ICG-lactosome for imaging spinal metastasis. A rat model of subcutaneous mammary tumor and a rat model of spinal metastasis of breast cancer were used. Fluorescence emitted by the subcutaneous tumors and the spinal metastasis were clearly detected for at least 24 h. Moreover, imaging of the dissected spine revealed clear fluorescence emitted by the metastatic lesion in the L6 vertebra while the normal bone lacked fluorescence. This study was the first report on NIR fluorescence imaging of spinal metastasis in vivo. NIR fluorescence imaging with ICG-lactosome could be an effective intraoperative imaging modality for detecting spinal metastasis.

Endoscopic near-infrared dental imaging with indocyanine green: a pilot study

2018 ◽  
Vol 1421 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Zhongqiang Li ◽  
Shaomian Yao ◽  
Jian Xu ◽  
Ye Wu ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Pilot Study ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Dental Imaging

scholarly journals Maltohexaose-indocyanine green (MH-ICG) for near infrared imaging of endocarditis

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247673
Author(s):  
Kiyoko Takemiya ◽  
Joachim J. Røise ◽  
Maomao He ◽  
Chung Taing ◽  
Alexander G. Rodriguez ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Indocyanine Green ◽  
Rat Model ◽  
Mammalian Cells ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Prosthetic Valve Endocarditis ◽  
High Specificity ◽  
Left Ventricular

Infectious endocarditis is a life-threatening disease, and diagnostics are urgently needed to accurately diagnose this disease especially in the case of prosthetic valve endocarditis. We show here that maltohexaose conjugated to indocyanine green (MH-ICG) can detect Staphylococcus aureus (S. aureus) infection in a rat model of infective endocarditis. The affinity of MH-ICG to S. aureus was determined and had a Km and Vmax of 5.4 μM and 3.0 X 10−6 μmol/minutes/108 CFU, respectively. MH-ICG had no detectable toxicity to mammalian cells at concentrations as high as 100 μM. The in vivo efficiency of MH-ICG in rats was evaluated using a right heart endocarditis model, and the accumulation of MH-ICG in the bacterial vegetations was 2.5 ± 0.2 times higher than that in the control left ventricular wall. The biological half-life of MH-ICG in healthy rats was 14.0 ± 1.3 minutes, and approximately 50% of injected MH-ICG was excreted into the feces after 24 hours. These data demonstrate that MH-ICG was internalized by bacteria with high specificity and that MH-ICG specifically accumulated in bacterial vegetations in a rat model of endocarditis. These results demonstrate the potential efficacy of this agent in the detection of infective endocarditis.

scholarly journals The Optical Properties of Indocyanine Green suspended in Solution as Observed under Near Infrared LED and LASER Light Conditions

2021 ◽  
Vol 10 (5) ◽  
pp. 080-089
Author(s):  
Angharad Curtis ◽  
Kang Li ◽  
Mohammed Ali ◽  
Nigel Copner
Keyword(s):  
Optical Properties ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Laser Light ◽  
Optical Power ◽  
Excitation Power ◽  
Light Conditions ◽  
Cmos Camera ◽  
Fluorescent Marker ◽  
Optimal Imaging

The use of Indocyanine Green (ICG) as a fluorescent marker at Near Infrared (NIR) excitation wavelengths is well established in clinical imaging. Typical systems comprise multiple LED sources for optimal imaging which can result in unnecessary energy transfer to patients and contribute to tissue damage. An experimental setup comprising a 780 nm excitation channel generating up to 10 mW of optical power is used in order to determine if there is potential to exploit the optical properties of ICG, in order to reduce the total excitation power through pulsing. We demonstrate in this work that a single 1.6 Megapixel CMOS camera with quantum efficiency of less than 30% is appropriate to capture both fluorescent and non-fluorescent landmarks at NIR wavelengths. Experimental results verify that all ICG solutions tested yielded detectable fluorescence and that degradation of fluorescence intensity over time is multifaceted.

scholarly journals Characterization of materials for optimal near-infrared and x-ray imaging of the breast

2012 ◽  
Vol 3 (9) ◽  
pp. 2078 ◽  
Author(s):  
Kelly Michaelsen ◽  
Venkataramanan Krishnaswamy ◽  
Brian W. Pogue ◽  
Ken Brooks ◽  
Ken Defreitas ◽  
...  
Keyword(s):  
Near Infrared ◽  
X Ray ◽  
X Ray Imaging ◽  
Characterization Of Materials

scholarly journals Mapping gadolinium contrast in a complex ionic and photosynthesis environment of pineapple by near-infrared and X-ray imaging

2020 ◽  
Vol 53 (7) ◽  
pp. 505-511
Author(s):  
Subhendra Sarkar ◽  
Zoya Vinokur ◽  
Chen Xu ◽  
Tetiana Soloviova ◽  
Amina Shahbaz ◽  
...  
Keyword(s):  
Near Infrared ◽  
Gadolinium Contrast ◽  
X Ray ◽  
X Ray Imaging
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