Self‐assembly of lipid rafts revealed by fluorescence correlation spectroscopy in living breast cancer cells

2019 ◽  
Vol 13 (2) ◽  
Author(s):  
Shiqing Dong ◽  
Xiaoqiong Tang ◽  
Jiao Wang ◽  
Zhenghong Zhang ◽  
Jianling Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Self Assembly ◽  
Fluorescence Correlation Spectroscopy ◽  
Breast Cancer Cells ◽  
Correlation Spectroscopy ◽  
Fluorescence Correlation

scholarly journals Drug-Triggered Self-Assembly of Linear Polymer into Nanoparticles for Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs in Breast Cancer Cells

ACS Omega ◽  
2017 ◽  
Vol 2 (12) ◽  
pp. 8730-8740 ◽  
Author(s):  
Sandeep Palvai ◽  
Libi Anandi ◽  
Sujit Sarkar ◽  
Meera Augustus ◽  
Sudip Roy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Linear Polymer ◽  
Hydrophilic Drugs ◽  
Simultaneous Delivery

l-Cysteine/AgNO2 low molecular weight gelators: self-assembly and suppression of MCF-7 breast cancer cells

Soft Matter ◽  
2020 ◽  
Vol 16 (42) ◽  
pp. 9669-9673
Author(s):  
Dmitry V. Vishnevetskii ◽  
Arif R. Mekhtiev ◽  
Tatyana V. Perevozova ◽  
Dmitry V. Averkin ◽  
Alexandra I. Ivanova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Weight ◽  
Cancer Cells ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Low Molecular Weight ◽  
Human Breast ◽  
Selective Toxicity ◽  
Low Molecular Weight Gelators ◽  
Mcf 7

We present a method for the preparation of a new hydrogel based on low molecular weight gelators that exhibits selective toxicity towards MCF-7 human breast cancer cells.

Supramolecular assembly of fluorogenic glyco-dots from perylenediimide-based glycoclusters for targeted imaging of cancer cells

2017 ◽  
Vol 53 (87) ◽  
pp. 11937-11940 ◽  
Author(s):  
Ying Liu ◽  
Ding-Kun Ji ◽  
Lei Dong ◽  
Nicolas Galanos ◽  
Yi Zang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Supramolecular Assembly ◽  
Targeted Imaging

Supramolecular self-assembly between perylenediimide-based glycoclusters and a red-emitting fluorophore produces structurally uniform and stable glyco-dots amenable to targeted fluorogenic imaging of liver and triple-negative breast cancer cells.

scholarly journals 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3164
Author(s):  
Meran Keshawa Ediriweera ◽  
Jeong Yong Moon ◽  
Yen Thi-Kim Nguyen ◽  
Somi Kim Cho
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Triple Negative Breast Cancer ◽  
Lipid Raft ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling ◽  
Migration And Invasion ◽  
Membrane Raft

10-Gingerol is a major phenolic lipid found in the rhizomes of ginger (Zingiber officinale). Being amphiphilic in nature, phenolic lipids have the ability to incorporate into cell membranes and modulate membrane properties. The purpose of the present study was to evaluate the effects of 10-gingerol on lipid raft/membrane raft modulation in radio-resistant triple negative breast cancer (MDA-MB-231/IR) cells. The effects of 10-gingerol on MDA-MB-231/IR cells’ proliferation, clonogenic growth, migration, and invasion were assayed using MTT, colony formation, cell migration, and invasion assays, respectively. Sucrose density gradient centrifugation was used to extract lipid rafts. Western blotting and immunofluorescence were employed to assess the effects of 10-gingerol on lipid raft/membrane raft modulation and lipid rafts-associated PI3K/Akt signaling. Cholesterol measurements were carried out using a commercially available kit. 10-gingerol suppressed the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. Moreover, 10-gingerol was found to modulate the lipid rafts of MDA-MB-231/IR cells and attenuate the key PI3K/Akt signaling components in lipid rafts. The cholesterol content of the lipid rafts and rafts-resident Akt signaling were also affected by exposure to 10-gingerol. The results of the present study highlight rafts-associated PI3K/Akt signaling as a new target of 10-gingerol in MDA-MB-231/IR cells, thus rationalizing a new rafts-mediated treatment approach for radio-resistant triple negative breast cancer cells.

scholarly journals Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Hari Raghu ◽  
Prasanna Kumar Sodadasu ◽  
Rama Rao Malla ◽  
Christopher S Gondi ◽  
Norman Estes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast
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