scholarly journals Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results

2019 ◽  
Vol 12 (9) ◽  
Author(s):  
Kristen M. Meiburger ◽  
Zhe Chen ◽  
Christoph Sinz ◽  
Erich Hoover ◽  
Michael Minneman ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Skin Lesion ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Optical Coherence Tomography Angiography ◽  
Lesion Area ◽  
Preliminary Results ◽  
Area Determination

scholarly journals Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy

2020 ◽  
pp. 1-9
Author(s):  
Sabrina Bergeron ◽  
Bryan Arthurs ◽  
Debra-Meghan Sanft ◽  
Christina Mastromonaco ◽  
Miguel N. Burnier Jr.
Keyword(s):  
Squamous Cell Carcinoma ◽  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Lesions ◽  
Sebaceous Carcinoma ◽  
Optical Coherence ◽  
Oct Imaging

<b><i>Introduction:</i></b> Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. <b><i>Objective:</i></b> We aim to validate OCT as an imaging modality for peri-ocular skin cancer. Through a series of cases, we highlight findings for 3 common eyelid malignancies: basal cell carcinoma, squamous cell carcinoma and sebaceous carcinoma. We propose an OCT image-based signature for basal cell carcinoma. <b><i>Methods:</i></b> This is a prospective study. Fifty-eight lesions suspicious of malignancy from 57 patients were subjected to OCT imaging prior to the surgical excision of the lesion. OCT images were analysed and scored according to previously identified OCT features. Eight representative examples are presented, highlighting the OCT patterns for each malignancy side by side to its corresponding histopathological sections. <b><i>Results:</i></b> Out of the 58 lesions analysed, 53 were malignant. A loss of the dermal-epidermal junction is observed in all malignant lesions. A strong link is observed between the presence of subepithelial hyporeflective nests on OCT and the diagnosis of basal cell carcinoma (present in 83% of cases). Conversely, lesions of epithelial origin such as squamous cell carcinoma are most often represented on OCT by acanthosis. Two supplementary cases, one basal cell carcinoma and one sebaceous carcinoma, are provided to illustrate how OCT imaging is a valuable tool in cases where clinical observations may be unusual. <b><i>Conclusions:</i></b> We provide evidence supporting the use of OCT for the evaluation of peri-ocular cancers. OCT enables visualization of the skin layers in vivo, before biopsy. Our results show that certain OCT features can contribute to include or exclude a diagnosis of basal cell carcinoma. By integrating this non-invasive imaging methodology into the routine assessment of peri-ocular skin lesions, especially in health care centres where access to specialists is limited, OCT imaging can increase clinical precision, reduce delays in patient referral and enhance patient care.

Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma

2004 ◽  
Vol 9 (2) ◽  
pp. 292 ◽  
Author(s):  
John Strasswimmer ◽  
Mark C. Pierce ◽  
B. Hyle Park ◽  
Victor Neel ◽  
Johannes F. de Boer
Keyword(s):  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Optical Coherence

scholarly journals Optical Coherence Tomography for Noninvasive Diagnosis and Subtyping of Basal Cell Carcinoma: A Prospective Cohort Study

2020 ◽  
Vol 140 (10) ◽  
pp. 1962-1967
Author(s):  
Kelly A.E. Sinx ◽  
Eva van Loo ◽  
Erwin H.J. Tonk ◽  
Nicole W.J. Kelleners-Smeets ◽  
Veronique J.L. Winnepenninckx ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cohort Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prospective Cohort Study ◽  
Basal Cell ◽  
Prospective Cohort ◽  
Noninvasive Diagnosis ◽  
Optical Coherence

Giant Basal Cell Carcinoma of the Forehead with Extensive Intracranial Involvement

2007 ◽  
Vol 116 (9) ◽  
pp. 663-666 ◽  
Author(s):  
Ilka Charlotte Naumann ◽  
Susan R. Cordes
Keyword(s):  
Skin Lesion ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Growth Pattern ◽  
Cancer Surveillance ◽  
Review Of The Literature ◽  
Intracranial Involvement ◽  
Malignant Skin ◽  
Giant Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most common malignant skin lesion and is frequently curatively treated with local excision. Improper removal or neglect of BCC is a particular problem for head and neck surgeons. We describe a case of a recurrent BCC that aggressively grew from the forehead skin through the skull and into the frontal lobe. We also present a review of the literature. Despite its fairly benign growth pattern, BCC should never be underestimated, and care should be taken not only in the complete primary excision but also in cancer surveillance.

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