Multi‐wavelength light emitting diode‐based disposable optrode array for in vivo optogenetic modulation

2019 ◽  
Vol 12 (5) ◽  
Author(s):  
Saeyeong Jeon ◽  
Jae‐Hyun Kim ◽  
Hongkyun Lee ◽  
Yong‐Kweon Kim ◽  
Sang Beom Jun ◽  
...  
Keyword(s):  
Light Emitting Diode ◽  
Light Emitting ◽  
Multi Wavelength ◽  
Wavelength Light

scholarly journals Multi-wavelength light-emitting diode light source radar system and near-ground atmospheric aerosol detection

2018 ◽  
Vol 67 (18) ◽  
pp. 184208
Author(s):  
Zhong Wen-Ting ◽  
Liu Jun ◽  
Hua Deng-Xin ◽  
Hou Hai-Yan ◽  
Yan Ke-Jun
Keyword(s):  
Light Source ◽  
Atmospheric Aerosol ◽  
Light Emitting Diode ◽  
Radar System ◽  
Light Emitting ◽  
Multi Wavelength ◽  
Wavelength Light

scholarly journals Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 725
Author(s):  
Saeyeong Jeon ◽  
Youjin Lee ◽  
Daeho Ryu ◽  
Yoon Kyung Cho ◽  
Yena Lee ◽  
...  
Keyword(s):  
Light Emitting Diode ◽  
Neural Recording ◽  
Electrophysiological Recording ◽  
Light Emitting ◽  
Technological Advances ◽  
Neuroscience Research ◽  
Cell Type Specific ◽  
Novel Design

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

scholarly journals In vitro and in vivo Efficacy of New Blue Light Emitting Diode Phototherapy Compared to Conventional Halogen Quartz Phototherapy for Neonatal Jaundice

2005 ◽  
Vol 20 (1) ◽  
pp. 61 ◽  
Author(s):  
Yun Sil Chang ◽  
Jong Hee Hwang ◽  
Hyuk Nam Kwon ◽  
Chang Won Choi ◽  
Sun Young Ko ◽  
...  
Keyword(s):  
Blue Light ◽  
Neonatal Jaundice ◽  
Light Emitting Diode ◽  
In Vivo Efficacy ◽  
Light Emitting

Retinal damage related to high-intensity light-emitting diode exposure: An in vivo study

2021 ◽  
Author(s):  
Marcela Emílio de Araújo ◽  
Marina Bozzini Paies ◽  
Ana Beatriz Arrais ◽  
Fernando Ladd Lobo ◽  
Ruthnaldo Rodrigues Melo de Lima ◽  
...  
Keyword(s):  
High Intensity ◽  
Light Emitting Diode ◽  
In Vivo Study ◽  
Retinal Damage ◽  
Light Emitting ◽  
High Intensity Light

scholarly journals Light-Emitting-Diode-Based Multispectral Photoacoustic Computed Tomography System

Sensors ◽  
2019 ◽  
Vol 19 (22) ◽  
pp. 4861 ◽  
Author(s):  
Sumit Agrawal ◽  
Christopher Fadden ◽  
Ajay Dangi ◽  
Xinyi Yang ◽  
Hussain Albahrani ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Molecular Imaging ◽  
Photoacoustic Imaging ◽  
Light Emitting Diode ◽  
Low Cost ◽  
Tunable Laser ◽  
Cost Effective ◽  
Light Emitting ◽  
Multi Wavelength ◽  
Human Finger

Photoacoustic computed tomography (PACT) has been widely explored for non-ionizing functional and molecular imaging of humans and small animals. In order for light to penetrate deep inside tissue, a bulky and high-cost tunable laser is typically used. Light-emitting diodes (LEDs) have recently emerged as cost-effective and portable alternative illumination sources for photoacoustic imaging. In this study, we have developed a portable, low-cost, five-dimensional (x, y, z, t, λ ) PACT system using multi-wavelength LED excitation to enable similar functional and molecular imaging capabilities as standard tunable lasers. Four LED arrays and a linear ultrasound transducer detector array are housed in a hollow cylindrical geometry that rotates 360 degrees to allow multiple projections through the subject of interest placed inside the cylinder. The structural, functional, and molecular imaging capabilities of the LED–PACT system are validated using various tissue-mimicking phantom studies. The axial, lateral, and elevational resolutions of the system at 2.3 cm depth are estimated as 0.12 mm, 0.3 mm, and 2.1 mm, respectively. Spectrally unmixed photoacoustic contrasts from tubes filled with oxy- and deoxy-hemoglobin, indocyanine green, methylene blue, and melanin molecules demonstrate the multispectral molecular imaging capabilities of the system. Human-finger-mimicking phantoms made of a bone and blood tubes show structural and functional oxygen saturation imaging capabilities. Together, these results demonstrate the potential of the proposed LED-based, low-cost, portable PACT system for pre-clinical and clinical applications.

scholarly journals A multi-channel photometric detector for multi-component analysis in flow injection analysis

1994 ◽  
Vol 16 (2) ◽  
pp. 71-73 ◽  
Author(s):  
Aimin Tan ◽  
Jialin Huang ◽  
Liudi Geng ◽  
Jinhua Xu ◽  
Xinna Zhao
Keyword(s):  
Zinc Sulphate ◽  
Light Emitting Diode ◽  
Single Chip ◽  
Single Chip Microcomputer ◽  
Light Emitting ◽  
Flow Cells ◽  
Photometric Detector ◽  
Sulphate Electrolyte ◽  
Multi Wavelength

The detector, a multi-channel photometric detector, described in this paper was developed using multi-wavelength LEDs (light emitting diode) and phototransistors for absorbance measurement controlled by an Intel 8031 8-bit single chip microcomputer. Up to four flow cells can be attached to the detector. The LEDs and phototransistors are both inexpensive, and reliable. The results given by the detector for simultaneous determination of trace amounts of cobalt and cadmium in zinc sulphate electrolyte are reported. Because of the newly developed detector, this approach employs much less hardware apparatus than by employing conventional photometric detectors.

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