Investigation of brain functional connectivity in patients with mild cognitive impairment: A functional near‐infrared spectroscopy (fNIRS) study

2019 ◽  
Vol 12 (9) ◽  
Author(s):  
Thien Nguyen ◽  
Minhee Kim ◽  
Jeonghwan Gwak ◽  
Jang J. Lee ◽  
Kyu Y. Choi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Infrared Spectroscopy ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Functional Near Infrared Spectroscopy ◽  
Brain Functional Connectivity

Photobiomodulation Enhances Memory Processing in Older Adults with Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy Study

2021 ◽  
pp. 1-10
Author(s):  
Agnes S. Chan ◽  
Tsz-lok Lee ◽  
Michael R. Hamblin ◽  
Mei-chun Cheung
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Infrared Spectroscopy ◽  
Mild Cognitive Impairment ◽  
Near Infrared Spectroscopy ◽  
Visual Memory ◽  
Near Infrared ◽  
Memory Span ◽  
Memory Performance ◽  
Functional Near Infrared Spectroscopy

Background: Recent studies of photobiomodulation (PBM) in patients with cognitive or psychological disorders (including traumatic brain injury, stroke, and dementia) have yielded some encouraging results. Objective: In this study, we aimed to investigate the effect of a single stimulation on memory in older adults with mild cognitive impairment (MCI). Methods: After PBM, hemodynamic changes, as a measure of functional brain activity, were evaluated using functional near-infrared spectroscopy (fNIRS). Eighteen subjects who met the criteria of MCI were randomly assigned to control and experimental groups. A single real or sham PBM session was administered to the forehead of each patient in the experimental and control groups, respectively. All subjects performed a visual memory span test before and after the stimulation, and their hemodynamic responses during the tasks were measured using fNIRS. Results: The results showed that among the MCI subjects, only those who received PBM, but not those who received the sham stimulation, demonstrated significant improvement in the visual memory performance and a reduction in the hemodynamic response during the tasks. Conclusion: These findings suggest that PBM may reduce the cognitive efforts needed to complete tasks that require high memory loads, and thus improve the cognitive performance of individuals with MCI.

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