scholarly journals Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition

2018 ◽  
Vol 11 (9) ◽  
pp. e201700289 ◽  
Author(s):  
Zahra Ghanian ◽  
Shima Mehrvar ◽  
Nasim Jamali ◽  
Nader Sheibani ◽  
Mahsa Ranji
Keyword(s):  
Oxidative Stress ◽  
High Glucose ◽  
Time Lapse ◽  
Time Lapse Microscopy ◽  
Retinal Pericytes ◽  
High Glucose Condition ◽  
Glucose Condition

Grape seed proanthocyanidins improves mitochondrial function and reduces oxidative stress through an increase in sirtuin 3 expression in EA.hy926 cells in high glucose condition

2020 ◽  
Vol 47 (5) ◽  
pp. 3319-3330 ◽  
Author(s):  
Aline Fagundes Cerbaro ◽  
Victoria Soldatelli Borges Rodrigues ◽  
Marina Rigotti ◽  
Catia Santos Branco ◽  
Giovana Rech ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
High Glucose ◽  
Grape Seed ◽  
Sirtuin 3 ◽  
Grape Seed Proanthocyanidins ◽  
High Glucose Condition ◽  
Ea.Hy926 Cells ◽  
Glucose Condition

scholarly journals Fibroblast Growth Factor Type 1 Ameliorates High-Glucose-Induced Oxidative Stress and Neuroinflammation in Retinal Pigment Epithelial Cells and a Streptozotocin-Induced Diabetic Rat Model

2021 ◽  
Vol 22 (13) ◽  
pp. 7233
Author(s):  
Hsin-Wei Huang ◽  
Chung-May Yang ◽  
Chang-Hao Yang
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
High Glucose ◽  
Diabetic Rat ◽  
Fibroblast Growth ◽  
High Glucose Condition ◽  
Factor Type ◽  
Diabetic Rat Model ◽  
Glucose Condition

Diabetic retinopathy (DR) is a common complication of diabetes that causes severe visual impairment globally. The pathogenesis of DR is related to oxidative stress and chronic inflammation. The fibroblast growth factor type 1 (FGF-1) mitogen plays crucial roles in cell function, development, and metabolism. FGF-1 is involved in blood sugar regulation and exerts beneficial antioxidative and anti-inflammatory effects on various organ systems. This study investigated the antioxidative and anti-inflammatory neuroprotective effects of FGF-1 on high-glucose-induced retinal damage. The results revealed that FGF-1 treatment significantly reversed the harmful effects of oxidative stress and inflammatory mediators in retinal tissue in a streptozotocin-induced diabetic rat model. These protective effects were also observed in the in vitro model of retinal ARPE-19 cells exposed to a high-glucose condition. We demonstrated that FGF-1 attenuated p38 mitogen-activated protein kinase and nuclear factor-κB pathway activation under the high-glucose condition. Our results indicated that FGF-1 could effectively prevent retinal injury in diabetes. The findings of this study could be used to develop novel treatments for DR that aim to reduce the cascade of oxidative stress and inflammatory signals in neuroretinal tissue.

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