Internalization kinetics and cytoplasmic localization of functionalized diatomite nanoparticles in cancer cells by Raman imaging

2017 ◽  
Vol 11 (4) ◽  
pp. e201700207 ◽  
Author(s):  
Stefano Managò ◽  
Nunzia Migliaccio ◽  
Monica Terracciano ◽  
Michela Napolitano ◽  
Nicola M. Martucci ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Raman Imaging ◽  
Cytoplasmic Localization ◽  
Internalization Kinetics

scholarly journals Inside Cover: Internalization kinetics and cytoplasmic localization of functionalized diatomite nanoparticles in cancer cells by Raman imaging (J. Biophotonics 4/2018)

2018 ◽  
Vol 11 (4) ◽  
pp. e201870137 ◽  
Author(s):  
Stefano Managò ◽  
Nunzia Migliaccio ◽  
Monica Terracciano ◽  
Michela Napolitano ◽  
Nicola M. Martucci ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Raman Imaging ◽  
Cytoplasmic Localization ◽  
Internalization Kinetics

scholarly journals Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy

Biosensors ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 5 ◽  
Author(s):  
Mioara Larion ◽  
Tyrone Dowdy ◽  
Victor Ruiz-Rodado ◽  
Matthew Meyer ◽  
Hua Song ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Idh1 Mutation ◽  
Raman Imaging ◽  
Metabolic Changes ◽  
Isocitrate Dehydrogenase 1 ◽  
Fibrosarcoma Cells ◽  
Drug Treatments

Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas, fibrosarcoma, and other cancers leads to a novel metabolite, D-2-hydroxyglutarate, which is proposed to cause tumorigenesis. The production of this metabolite also causes vulnerabilities in cellular metabolism, such as lowering NADPH levels. To exploit this vulnerability, we treated glioma and fibrosarcoma cells that harbor an IDH1 mutation with an inhibitor of nicotinamide adenine dinucleotide (NAD+) salvage pathway, FK866, and observed decreased viability in these cells. To understand the mechanism of action by which the inhibitor FK866 works, we used Raman imaging microscopy and identified that proteins and lipids are decreased upon treatment with the drug. Raman imaging showed a different distribution of lipids throughout the cell in the presence of the drug compared with the untreated cells. We employed nuclear magnetic resonance NMR spectroscopy and mass spectrometry to identify the classes of lipids altered. Our combined analyses point to a decrease in cell division due to loss of lipid content that contributes to membrane formation in the in vitro setting. However, the FK866 drug did not have the same potency in vivo. The use of Raman imaging microscopy indicated an opposite trend of lipid distribution in the tissue collected from treated versus untreated mice when compared with the cells. These results demonstrate the role of Raman imaging microscopy to identify and quantify metabolic changes in cancer cells and tissue.

Monodisperse Au@Ag core-shell nanoprobes with ultrasensitive SERS-activity for rapid identification and Raman imaging of living cancer cells

Talanta ◽  
2019 ◽  
Vol 198 ◽  
pp. 45-54 ◽  
Author(s):  
Jie Chang ◽  
Amin Zhang ◽  
Zhicheng Huang ◽  
Yunsheng Chen ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Rapid Identification ◽  
Raman Imaging ◽  
Core Shell

Development of a new diagnostic Raman method for monitoring epigenetic modifications in the cancer cells of human breast tissue

2016 ◽  
Vol 8 (48) ◽  
pp. 8542-8553 ◽  
Author(s):  
Beata Brozek-Pluska ◽  
Monika Kopeć ◽  
Halina Abramczyk
Keyword(s):  
Cancer Cells ◽  
Breast Tissue ◽  
Epigenetic Modifications ◽  
Raman Imaging ◽  
Human Breast ◽  
Human Breast Tissue

Raman imaging can ‘upgrade’ cancer epigenetic tests and answer many questions by monitoring the biochemistry of cancer cells.

Photosensitizer Functionalized Nanodiamonds for Raman Imaging and Photodynamic Therapy of Cancer Cells

Langmuir ◽  
2021 ◽  
Author(s):  
Kuikui Zhang ◽  
Qingyue Guo ◽  
Qi Zhao ◽  
Futao Wang ◽  
Hui Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Raman Imaging ◽  
Photodynamic Therapy Of Cancer

Confocal Raman imaging study of uptake and distribution of antitumor agent Teraftal in living A549 cancer cells

1999 ◽  
pp. 491-492
Author(s):  
A. V. Feofanov ◽  
A. I. Grichine ◽  
L. A. Shitova ◽  
T. A. Karmakova ◽  
R. I. Iakubovskaya ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Imaging Study ◽  
Antitumor Agent ◽  
Raman Imaging ◽  
Confocal Raman
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